Immune and inflammation-related proteins include multiple family members, such as cytokines (e.g., IL, TNF), chemokines (e.g., CXCL, CCL), receptors (e.g., TLR, ILR), and signaling molecules (e.g., NF-κB, JAK/STAT). These proteins have diverse structural compositions and are localized to the cell membrane, cytoplasm, or nucleus. They participate in regulating immune responses and inflammation, influencing cytokine production, cell migration, and pathogen clearance by activating specific signaling pathways. The expression of these proteins is specific in different tissues and cells, and mutations or dysregulation in their gene expression are associated with the occurrence and development of various inflammatory diseases, infections, and autoimmune diseases.