The Lysyl Oxidase (LOX) family comprises a group of copper-dependent enzymes, primarily involved in the crosslinking of collagen and elastin, crucial for maintaining the structure and function of the extracellular matrix. LOX and its homologues (such as LOXL1-LOXL4) are expressed in various tissues, particularly in connective tissues. They promote intermolecular crosslinking by catalyzing the oxidation of lysine residues. The LOX family plays roles in cell proliferation, migration, tissue repair, and the progression of diseases such as fibrosis and cancer. Specific expression and mutations in these genes can affect their activity and are associated with the development and progression of various diseases, including the increased invasiveness of tumors and connective tissue diseases.