MAP3K is a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family responsible for initiating the MAPK signaling pathway, regulating cell growth, differentiation, apoptosis, and more. This family includes various members such as RAF, MEKK, and ASK, which possess different structural domains like the kinase activity domain. MAP3K is localized near the cell membrane or within the cell and activates the MAPK pathway by phosphorylating MAP2K. Its expression is tissue-specific and participates in various biological processes such as inflammatory and stress responses. Mutations in MAP3K genes are associated with various diseases, including cancer and developmental disorders.