The MBD family (Methyl-CpG Binding Domain proteins) is a group of proteins that can recognize and bind to methylated DNA, including members such as MBD1, MBD2, and MBD3. They possess a methyl-CpG binding domain (MBD) and other domains such as transcriptional repression domains. MBD proteins are primarily located in the cell nucleus and are involved in epigenetic regulation, such as gene silencing and chromatin remodeling. MBD genes are expressed in various cells and tissues, and their tissue-specific expression and mutations are associated with a variety of diseases, including cancer, neurodevelopmental disorders, and immune system diseases. For example, overexpression of MBD2 is associated with the occurrence of certain cancers.