Home Chemistry Organic Building Blocks Fluorinated Building Blocks Methyl 4-Fluorobenzoate
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—COOCH3).
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
Reduction: Methyl benzoate can be reduced to benzyl alcohol using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4). The ester functional group is reduced to an alcohol functional group.
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Methyl 4-fluoro-3-(trifluoromethyl)benzoate
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Methyl 4-fluoro-2-hydroxy-3-nitrobenzoate
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Methyl 3-amino-4-fluoro-2-methylbenzoate
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Methyl 2-bromo-4-fluoro-6-methylbenzoate
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Methyl 2-(chlorosulfonyl)-4-fluorobenzoate
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Methyl 2-amino-5-chloro-4-fluorobenzoate
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