Chemistry Organic Building Blocks Ketones Morpholin-3-One

Morpholin-3-One

Nucleophilic Addition: Morpholin-3-one can react with nucleophiles, such as primary amines, to form imine derivatives or substituted morpholinones. The reaction is typically catalyzed by an acid. Hydrolysis: Under acidic or basic conditions, the ketone functional group can undergo hydrolysis to form the corresponding carboxylic acid and morpholine. Reduction: The carbonyl group of morpholin-3-one can be reduced to the corresponding alcohol (morpholin-3-ol) using reducing agents like sodium borohydride (NaBH4). Ring Opening Reactions: The morpholine ring can be opened under various conditions. For example, treatment with strong acids can lead to ring opening and subsequent reactions with nucleophiles. Condensation Reactions: It can participate in condensation reactions to form a variety of products. For example, it can react with carbonyl compounds in the presence of acid catalysts to form β-lactams or other related products. Substitution Reactions: Depending on the reaction conditions and reagents, morpholin-3-one can undergo substitution reactions at various positions within the molecule. Cyclization Reactions: Under certain conditions, morpholin-3-one can participate in intramolecular cyclization reactions to form bicyclic or spirocyclic compounds.

Further Reading:

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(1E,4E)-1,5-Diphenylpenta-1,4-Dien-3-One (1E,6E)-1,7-Diphenylhepta-1,6-Diene-3,5-Dione (2-Aminophenyl)(Phenyl)Methanone (2-Bromophenyl)(Phenyl)Methanone (2-Chlorophenyl)(Phenyl)Methanone (2-Fluorophenyl)(Phenyl)Methanone (2-Hydroxyphenyl)(Phenyl)Methanone (2-Iodophenyl)(Phenyl)Methanone (3-Chlorophenyl)(Phenyl)Methanone (3-Fluorophenyl)(Phenyl)Methanone (3-Nitrophenyl)(Phenyl)Methanone (4-Aminophenyl)(Phenyl)Methanone (4-Bromophenyl)(Phenyl)Methanone (4-Chlorophenyl)(Phenyl)Methanone (4-Fluorophenyl)(Phenyl)Methanone (4-Hydroxyphenyl)(Phenyl)Methanone (4-Methoxyphenyl)(Phenyl)Methanone (4-Nitrophenyl)(Phenyl)Methanone (8S,14R)-6,7,8,9,10,11,12,13,14,15,16,17-Dodecahydro-3H-Cyclopenta[A]Phenanthren-3-One (E)-1-(2-Hydroxyphenyl)-3-Phenylprop-2-En-1-One (R)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-8-One 1,3-Dioxoisoindolin-2-Yl 2-Phenylacetate 1,3-Diphenylpropan-1-One 1,4-Diazepan-5-One 1,4-Dihydroisoquinolin-3(2H)-One 1-(1H-Indazol-1-Yl)Ethan-1-One 1-(1H-Indol-1-Yl)Ethan-1-One 1-(1H-Indol-3-Yl)Ethan-1-One 1-(1H-Pyrrolo[2,3-B]Pyridin-3-Yl)Ethan-1-One 1-(2-(Trifluoromethyl)Phenyl)Ethan-1-One 1-(2-Aminophenyl)Ethan-1-One 1-(2-Bromophenyl)Ethan-1-One 1-(2-Chlorophenyl)Ethan-1-One 1-(2-Fluorophenyl)Ethan-1-One 1-(2-Hydroxyphenyl)-2-Phenylethan-1-One 1-(2-Hydroxyphenyl)-3-Phenylprop-2-En-1-One 1-(2-Hydroxyphenyl)Ethan-1-One 1-(2-Iodophenyl)Ethan-1-One 1-(2-Methoxyphenyl)Ethan-1-One 1-(2-Nitrophenyl)Ethan-1-One 1-(3-(Benzyloxy)Phenyl)Ethan-1-One 1-(3-Aminophenyl)Ethan-1-One 1-(3-Chlorophenyl)Ethan-1-One 1-(3-Fluorophenyl)Ethan-1-One 1-(3-Hydroxyphenyl)Ethan-1-One 1-(3-Iodophenyl)Ethan-1-One 1-(3-Methoxy-2-Nitrophenyl)Ethan-1-One 1-(3-Methoxyphenyl)Ethan-1-One 1-(3-Nitrophenyl)Ethan-1-One 1-(3-Nitrophenyl)Propan-1-One 1-(4-(Benzyloxy)Phenyl)Ethan-1-One 1-(4-Fluorophenyl)Ethan-1-One 1-([1,1'-Biphenyl]-4-Yl)Ethan-1-One 1-(Benzofuran-2-Yl)Ethan-1-One 1-(Imidazo[1,2-A]Pyridin-3-Yl)Ethan-1-One 1-(M-Tolyl)Ethan-1-One 1-(Naphthalen-2-Yl)Ethan-1-One 1-(O-Tolyl)Ethan-1-One 1-(Piperidin-1-Yl)Ethan-1-One 1-(Pyrazin-2-Yl)Ethan-1-One 1-(Pyridin-2-Yl)Ethan-1-One 1-(Pyridin-3-Yl)Ethan-1-One 1-(Pyridin-4-Yl)Ethan-1-One 1-(Pyrimidin-2-Yl)Ethan-1-One 1-(Pyrimidin-4-Yl)Ethan-1-One 1-(Pyrrolidin-1-Yl)Ethan-1-One 1-(Thiazol-2-Yl)Ethan-1-One 1-(Thiophen-2-Yl)Ethan-1-One 1-Aminoanthracene-9,10-Dione 1-Benzylindoline-2,3-Dione 1-Benzylpiperidin-3-One 1-Chloroanthracene-9,10-Dione 1-Hydroxyanthracene-9,10-Dione 1-Methylpiperazin-2-One 1-Methylpyrrolidin-2-One 1-Phenylbutan-1-One 1-Phenylpentan-1-One 1-Phenylpiperidin-2-One 1-Phenylpropan-2-One 2,2,2-Trifluoro-1-Phenylethan-1-One 2,2-Dimethyl-1-Phenylpropan-1-One 2,2-Dimethyl-2H-Benzo[B][1,4]Oxazin-3(4H)-One 2,3,4,9-Tetrahydro-1H-Carbazol-1-One 2,3-Dihydrofuran-3-One 2,3-Dihydropyridin-2-One 2,5-Dichlorobenzoic Acid 2-Amino-1-(Pyrrolidin-1-Yl)Ethan-1-One 2-Benzalacetophenone 2-Benzoylbenzoic Acid 2-Chloro-1-Phenylethan-1-One 2-Chlorocyclohexa-2,5-Diene-1,4-Dione 2-Chloroquinazolin-4(3H)-One 2-Hydroxy-1,2-Diphenylethan-1-One 2-Hydroxy-1-Phenylethan-1-One 2-Hydroxycyclohexa-2,5-Diene-1,4-Dione 2-Hydroxyquinolin-4(1H)-One 2-Methoxycyclohexa-2,5-Diene-1,4-Dione 2-Methyl-1-Phenylpropan-1-One 2-Methyl-2H-Benzo[B][1,4]Oxazin-3(4H)-One 2-Methyl-3,4-Dihydroisoquinolin-1(2H)-One 2-Methylcyclohexa-2,5-Diene-1,4-Dione 2-Methylcyclohexan-1-One 2-Methylisoindolin-1-One 2-Methylisoindoline-1,3-Dione 2-Methylpyridazin-3(2H)-One 2-Oxo-2-Phenylacetaldehyde 2-Oxo-2-Phenylacetic Acid 3,3-Difluoropiperidin-4-One 3,3-Dimethylcyclohexan-1-One 3,3-Dimethylpiperidin-4-One 3,4-Dihydroquinoxalin-2(1H)-One 3-Acetyl-2H-Chromen-2-One 3-Aminopyrrolidin-2-One 3-Bromo-1H-Pyrrole-2,5-Dione 3-Chloro-1-Phenylpropan-1-One 3-Fluoropiperidin-4-One 3-Hydroxy-2-Phenyl-4H-Chromen-4-One 3-Hydroxypyrrolidin-2-One 3-Methylcyclohexan-1-One 3-Methylene-2,3-Dihydro-1H-Inden-1-One 3-Methylpiperazin-2-One 3-Methylpyrimidin-4(3H)-One 3-Oxo-3-Phenylpropanenitrile 3-Oxo-N-Phenylbutanamide 3-Phenyl-1-(Pyrrolidin-1-Yl)Propan-1-One 3-Phenyl-2-Thioxoimidazolidin-4-One 3-Phenylacrylaldehyde 3-Phenylimidazolidine-2,4-Dione 4,4,4-Trifluoro-1-Phenylbutane-1,3-Dione 4-(1,2,2-Triphenylvinyl)Benzaldehyde 4-(Hydroxymethyl)Pyrrolidin-2-One 4-Benzylmorpholin-3-One 4-Bromoisoindolin-1-One 4-Bromopyridazin-3(2H)-One 4-Chloro-1-Phenylbutan-1-One 4-Chloropyridazin-3(2H)-One 4-Fluoroindoline-2,3-Dione 4-Hydroxy-2H-Chromen-2-One 4-Hydroxydihydrofuran-2(3H)-One 4-Hydroxypiperidin-2-One 4-Hydroxypyrrolidin-2-One 4-Methyl-2H-Chromen-2-One 4-Methylisobenzofuran-1(3H)-One 4-Oxo-4-Phenylbutanoic Acid 4-Phenylbutan-2-One 4-Phenylcyclohexan-1-One 4-Phenylmorpholin-3-One 4-Phenylpyrrolidin-2-One 5,6-Dihydrobenzo[D]Thiazol-7(4H)-One 5-(Aminomethyl)Pyrrolidin-2-One 5-(Hydroxymethyl)Pyrrolidin-2-One 5-Bromoisoindolin-1-One 5-Bromoisoindoline-1,3-Dione 5-Bromopyrimidin-4(3H)-One 5-Chloroisoindoline-1,3-Dione 5-Chloropyrimidin-4(3H)-One 5-Chloropyrimidine-2,4(1H,3H)-Dione 5-Fluoro-3,4-Dihydronaphthalen-1(2H)-One 5-Fluorochroman-4-One 5-Fluoroindolin-2-One 5-Fluoroisoindolin-1-One 5-Fluoropyrimidin-4(3H)-One 5-Fluoropyrimidine-2,4(1H,3H)-Dione 5-Hydroxy-2-Phenyl-4H-Chromen-4-One 5-Hydroxypiperidin-2-One 5-Methoxy-2-Phenyl-4H-Chromen-4-One 5-Methyl-3,4-Dihydronaphthalen-1(2H)-One 5-Methylindolin-2-One 5-Oxopyrrolidine-2-Carboxylic Acid 6-Bromoisoindolin-1-One 6-Fluorochroman-4-One 6-Fluoroindoline-2,3-Dione 6-Fluoroisobenzofuran-1(3H)-One 6-Hydroxy-2,3-Dihydro-1H-Inden-1-One 6-Methoxy-2,3-Dihydro-1H-Inden-1-One 6-Methoxy-3,4-Dihydronaphthalen-1(2H)-One 6-Methoxyisoindolin-1-One 6-Methyl-2,3-Dihydro-1H-Inden-1-One 7,8-Dihydroquinolin-5(6H)-One 7-(Diethylamino)-2H-Chromen-2-One 7-Bromo-3,4-Dihydronaphthalen-1(2H)-One 7-Bromochroman-4-One 7-Bromoindoline-2,3-Dione 7-Bromoquinazolin-4(3H)-One 7-Chloro-3,4-Dihydronaphthalen-1(2H)-One 7-Fluorochroman-4-One 7-Fluoroindolin-2-One 7-Fluoroquinazolin-4(3H)-One 7-Hydroxy-2H-Chromen-2-One 7-Methoxy-2H-Chromen-2-One 7-Methoxy-3,4-Dihydronaphthalen-1(2H)-One 7-Methoxychroman-4-One 7-Methylindoline-2,3-Dione 8-Bromochroman-4-One 8-Fluoro-3,4-Dihydronaphthalen-1(2H)-One 8-Fluoroisoquinolin-1(2H)-One 8-Methylchroman-4-One Acetophenone Azepan-2-One Benzo[Cd]Indol-2(1H)-One Benzofuran-2(3H)-One Chroman-2-One Cyclobutanone Cyclohex-2-En-1-One Cyclohexane-1,3-Dione Cyclopent-2-En-1-One Cyclopentane-1,3-Dione Dihydro-2H-Pyran-2,6(3H)-Dione Dihydrofuran-2,5-Dione Dihydrofuran-3(2H)-One Dihydrothiophen-3(2H)-One Ethene-1,1-Diyldibenzene Ethyl 2-Oxo-2-Phenylacetate Ethyl 3-Oxo-3-Phenylpropanoate Furan-2(5H)-One Isoquinolin-1-Ol Methyl 3-Oxo-3-Phenylpropanoate Morpholin-3-One Phenyl(3-(Trifluoromethyl)Phenyl)Methanone Phenyl(M-Tolyl)Methanone Phenyl(P-Tolyl)Methanone Phenyl(Pyridin-3-Yl)Methanone Phenyl(Thiophen-2-Yl)Methanone Piperidine-2,4-Dione Propiophenone Pyrimidine-4,6(1H,5H)-Dione Tert-Butyl (2-Oxopiperidin-3-Yl)Carbamate Tert-Butyl (2-Oxopyrrolidin-3-Yl)Carbamate Tert-Butyl (3-Oxocyclohexyl)Carbamate Tert-Butyl (5-Oxopyrrolidin-3-Yl)Carbamate Tert-Butyl (6-Oxopiperidin-3-Yl)Carbamate Tert-Butyl 2-Oxopiperidine-1-Carboxylate Tert-Butyl 2-Oxopyrrolidine-1-Carboxylate Tert-Butyl 4-Oxopiperidine-1-Carboxylate Tetrahydropyrimidin-2(1H)-One

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