Home Chemistry Organic Building Blocks Aryls N-Phenyl-2-Naphthamide
Acylation: N-phenyl-2-naphthamide can undergo acylation reactions, where an acyl group is introduced to the amide nitrogen. For example, reaction with an acid chloride or anhydride can yield N-phenyl-2-naphthamide derivatives with different acyl groups.
Reduction: N-phenyl-2-naphthamide can be reduced to form N-phenyl-2-naphthylamine using reducing agents like lithium aluminum hydride (LiAlH4) or other suitable reducing agents.
Amidation: It can participate in amidation reactions, where the amide bond is modified or extended through reactions with various amines and appropriate coupling agents.
Cyclization: Depending on the reaction conditions and reagents used, N-phenyl-2-naphthamide can undergo intramolecular cyclization reactions to form cyclic compounds.
Oxidation: Under certain conditions and with the right oxidizing agents, it may be possible to oxidize N-phenyl-2-naphthamide to generate oxidized products.
Substitution: N-phenyl-2-naphthamide can undergo electrophilic aromatic substitution reactions, where the phenyl ring is substituted with various functional groups.
Hydrolysis: N-phenyl-2-naphthamide can be hydrolyzed under acidic or basic conditions to produce naphthylamine and benzoic acid as the respective products.
Reactions with Lewis Acids: It can react with Lewis acids, such as aluminum chloride (AlCl3) or boron trifluoride (BF3), in various reactions like Friedel-Crafts acylation or alkylation, leading to the introduction of different substituents onto the naphthalene ring.
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3-Hydroxy-N-(3-methoxyphenyl)-2-naphthamide
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N-(5-Chloro-2-methoxyphenyl)-3-hydroxy-2-naphthamide
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N-(5-Chloro-2-methylphenyl)-3-hydroxy-2-naphthamide
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N-(4-Chloro-2-methylphenyl)-3-hydroxy-2-naphthamide
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N-(4-Chloro-2,5-dimethoxyphenyl)-3-hydroxy-2-naphthamide
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