OSBP (Oxysterol-Binding Protein) is a protein involved in the intracellular transport of cholesterol and lipids. Members of the OSBP family have specific binding domains that recognize and bind cholesterol, mediating its transport between organelles, especially from the endoplasmic reticulum to the Golgi apparatus. In this way, OSBP regulates the lipid composition and fluidity of cell membranes, affecting signal transduction, membrane transport, and cell proliferation. The expression of OSBP family members varies among different cells and tissues, and their dysfunction is associated with the development of various diseases, such as cardiovascular diseases and tumors.