The OSBPL family, or Oxysterol-Binding Protein-Like family, comprises several members involved in mediating intracellular lipid transport and signaling. These proteins interact with various lipids within cells through their oxysterol-binding domains, playing roles in regulating cell membrane composition and lipid metabolism. OSBPL proteins are specifically expressed in various cells and tissues, with their activity and localization crucial for maintaining intracellular lipid balance and signal transmission. Abnormal expression and mutations of OSBPL genes are associated with the development of various diseases, including cardiovascular diseases and metabolic syndrome.