PDK-1 (3-Phosphoinositide Dependent Protein Kinase-1) is a critical member of the AGC (PKA/PKG/PKC) kinase family, possessing a single catalytic domain and a PH (pleckstrin homology) domain, primarily localized in the cytoplasm. PDK-1 plays a central role in cell growth, division, survival, and metabolism by phosphorylating and activating AKT and other AGC family members, transmitting insulin and growth factor signals. PDK-1 is widely expressed in various cells and tissues, and the regulation of its activity and expression levels is essential for maintaining the balance of intracellular signal transduction. Variations and mutations in PDK-1 gene expression are associated with various diseases such as cancer, metabolic disorders, and cardiovascular diseases.