Home Chemistry Heterocyclic Building Blocks Piperidines Piperidin-4-Amine
Acylation: Piperidin-4-amine can react with acyl chlorides or anhydrides to form amides. This reaction typically occurs under basic conditions.
Alkylation: The amine group of piperidin-4-amine can be alkylated with alkyl halides or sulfonates, leading to the formation of N-substituted piperidines.
Reductive Amination: Piperidin-4-amine can undergo reductive amination reactions with carbonyl compounds (aldehydes or ketones) in the presence of reducing agents such as sodium cyanoborohydride or sodium triacetoxyborohydride to yield secondary amines.
Condensation Reactions: It can participate in condensation reactions, such as the Mannich reaction, where it reacts with formaldehyde and a secondary amine to form β-amino alcohols.
Hofmann Elimination: Under appropriate conditions, piperidin-4-amine can undergo Hofmann elimination to form an alkene.
Reduction: The amino group in piperidin-4-amine can be reduced to form a secondary amine or further to a tertiary amine using reducing agents like lithium aluminum hydride or hydrogen in the presence of a catalyst.
Diazo Coupling: Piperidin-4-amine can undergo diazo coupling reactions to form azo compounds when reacted with diazonium salts.
Cyclization Reactions: Due to its cyclic structure, piperidin-4-amine can participate in various cyclization reactions, such as ring-opening reactions or intramolecular cyclizations to form heterocyclic compounds.
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tert-Butyl 4-amino-2-isopropylpiperidine-1-carboxylate
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tert-Butyl 4-aminopiperidine-1-carboxylate hydrochloride
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1-(4-Aminopiperidin-1-yl)-2,2-dimethylpropan-1-one hydrochloride
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2-(4-Aminopiperidin-1-yl)acetamide dihydrochloride
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1-Ethylpiperidin-4-amine dihydrochloride
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Methyl 4-aminopiperidine-1-carboxylate
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1-Propylpiperidin-4-amine dihydrochloride
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1-(2-Fluoroethyl)piperidin-4-amine dihydrochloride
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