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Chemical Structure| 1188890-41-6 Chemical Structure| 1188890-41-6

Structure of (E)-KN-93 phosphate
CAS No.: 1188890-41-6

Chemical Structure| 1188890-41-6

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KN-93 Phosphate, a potent Ca2+/calmodulin-dependent protein kinase II (CaMKII) selective inhibitor with Ki of 370 nM, is the water soluble version of KN-93.

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Product Details of (E)-KN-93 phosphate

CAS No. :1188890-41-6
Formula : C26H32ClN2O8PS
M.W : 599.03
SMILES Code : O=S(C1=CC=C(OC)C=C1)(N(C2=CC=CC=C2CN(C/C=C/C3=CC=C(Cl)C=C3)C)CCO)=O.O=P(O)(O)O
MDL No. :MFCD03788201
InChI Key :NNKJTPOXLIILMB-IPZCTEOASA-N
Pubchem ID :16760530

Safety of (E)-KN-93 phosphate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
CPVT-iPSC-derived cardiomyocytes 1 µM 2-3 minutes KN-93 significantly reduced isoproterenol-induced delayed afterdepolarizations (DADs) in CPVT-CMs, rescuing the arrhythmic phenotype induced by catecholaminergic stress. PMC3824678

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
mice OVA-induced allergic airway disease model intranasal administration 10 mg/kg or 2 mg/kg days 1 and 2 post-infection or days 4 and 5 post-infection Test the effect of KN-93 on asthma symptoms in OVA mice, found that inhaled KN-93 significantly reduced airway hyperresponsiveness (AHR), goblet cell hyperplasia, epithelial thickness, and Muc5ac mRNA levels. PMC4331168
Mice Allergen-induced asthma model Intratracheal administration 20 mg/kg Daily until endpoint Suppressed OVA-induced mast cell activation and asthma PMC5214090
Rats Ischemia/Reperfusion Injury Model Perfusion 1 mg/kg Daily administration for 28 weeks CaMKII inhibition significantly increased the recovery of left ventricular developed pressure and reduced infarct size and LDH release, indicating prevention of ischemia/reperfusion-induced necrosis and apoptosis. PMC2866824

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.67mL

0.33mL

0.17mL

8.35mL

1.67mL

0.83mL

16.69mL

3.34mL

1.67mL

 

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