Alternatived Products of [ 1000160-74-6 ]
Product Details of [ 1000160-74-6 ]
CAS No. : | 1000160-74-6 |
MDL No. : | MFCD16995819 |
Formula : |
C14H17BO2S
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | PNPHOIZEFCAWEB-UHFFFAOYSA-N |
M.W : |
260.16
|
Pubchem ID : | 66673976 |
Synonyms : |
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Safety of [ 1000160-74-6 ]
Application In Synthesis of [ 1000160-74-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1000160-74-6 ]
- 1
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[ 1000160-74-6 ]
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[ 153034-94-7 ]
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[ 1034658-77-9 ]
Yield | Reaction Conditions | Operation in experiment |
82% |
With sodium carbonate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; johnphos; In tetrahydrofuran; water; at 100℃; for 3h; |
Preparation 18; 4-Benzo[£]thiophen-7-yl-2-fluoro-5-methyl-pyridine; In a flask, combine <strong>[153034-94-7]2-fluoro-4-iodo-5-methyl-pyridine</strong> (355 mg, 1.5 mmol), 2- benzo[£]thiophen-7-yl-4,4,5,5-tetramethyl-[l,3,2]dioxaborolane (282 mg, 1.8 mmol), [l,r-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane (1: 1) (61 mg, 0.07 mmol), 2-(di-tert-butylphosphino)biphenyl (13 mg, 0.04 mmol), sodium carbonate (2 M, 1.5 mL, 3 mmol) and THF (10 mL). Heat the mixture at 100 0C for 3 hours in an oil bath. Dilute the mixture with chloroform/isopropanol (3/1). Wash the solution with saturated aqueous sodium chloride. Dry over sodium sulfate. Concentrate in vacuo to a dark residue. Purify by column chromatography (20 % ethyl acetate in hexane) to afford the title compound (300 mg, 82 %) as yellow oil. MS (ES) m/z 244 [M+ 1]+. |
82% |
With sodium carbonate; johnphos;(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; at 100℃; for 3h; |
Preparation 844-Benzo[b]thiophen-7-yl-2-fluoro-5-methyl-pyridineIn a flask, combine <strong>[153034-94-7]2-fluoro-4-iodo-5-methyl-pyridine</strong> (355 mg,1.5 mmol), 2- benzo[b]thiophen-7-yl-4,4,5,5-tetramethyl-[l,3,2]dioxaborolane (282 mg, 1.8 mmol), Pd(dppf)Cl2 (61 mg, 0.07 mmol), 2-(di-tert-butylphos-phino)biphenyl (13 mg, 0.04 mmol), sodium carbonate (2 M, 1.5 mL, 3 mmol) and THF (10 mL). Heat the mixture at 100 0C for 3 h in an oil bath. Dilute the mixture with chloroform/IPA (3/1). Wash the solution with aqueous saturated sodium chloride. Dry over sodium sulfate. Concentrate in vacuo to a dark residue. Purify by column chromatography (20 % ethyl acetate in hexane) to afford the title compound (300 mg, 82 %) as a yellow oil. MS (ES) m/z 244 |