There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | ||||||
{[ item.p_purity ]} | {[ item.pr_size ]} | Inquiry |
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price) ]} |
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price) ]} | {[ item.pr_usastock ]} | in stock Inquiry - | {[ item.pr_chinastock ]} | {[ item.pr_remark ]} in stock Inquiry - | Login | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
CAS No. : | 1000773-62-5 | MDL No. : | MFCD11846578 |
Formula : | C7H5BrF3N | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | UMXIAVUQROUXKO-UHFFFAOYSA-N |
M.W : | 240.02 | Pubchem ID : | 21441094 |
Synonyms : |
|
Signal Word: | Danger | Class: | 8 |
Precautionary Statements: | P501-P260-P270-P264-P280-P303+P361+P353-P301+P330+P331-P363-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P405 | UN#: | 1760 |
Hazard Statements: | H302-H314 | Packing Group: | Ⅱ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
86% | With phosphorus tribromide; In dichloromethane; at 0 - 20℃; | To an ice-cooled solution of (5-trifluoromethyl-pyridin-2-yl)-methanol (300 mg, 1.69 mmol) inDCM (10 mL) is added phosphoros tribromide (96 mul_, 1.02 mmol) and the reaction mixture is stirred for 2 h at room temperature. The reaction mixture is quenched with aqueous sodium bicarbonate solution and extracted with ethyl acetate. The organic layer is dried over MgSO4 and evaporated under reduced pressure.Yield: 350 mg (86% of theory); ESI Mass spectrum: [M+H]+ = 239Retention time HPLC: 1.37 min (method J). |
77% | With 1H-imidazole; bromine; triphenylphosphine; In dichloromethane; for 3h; | 2-(bromomethyl)-5-(trifluoromethyl)pyridine<strong>[31181-84-7][5-(trifluoromethyl)pyridin-2-yl]methanol</strong> (2.Og, 11.29 mmol) was dissolved in DCM (20 ml_) at r.t. Imidazole (824 mg, 11.9 mmol) was added and allowed to dissolve. Triphenylphosphine (3.36 g, 12.4 mmol) was then added and dissolved. Bromine (0.58 ml_, 11.3 mmol) was added last and stirred for 3 hours. The reaction was quenched water and extracted with dichloromethane (2x 25 ml_). The organics were dried with magnesium sulfate and concentrated. The crude product was purified by flash chromatography (heptanes:ethyl acetate) to give the title compound as a clear liquid (2.1 g, 8.75 mmol, 77%). |
Reference Production Example 2. In 70 mL of tetrahydrofuran, 4.44 g of (5- trifluoromethylpyridin-2-yl) methanol was dissolved and 1.9 mL of methanesulfonyl chloride and 3.5 mL of triethylamine were added dropwise at 00C. After stirring at the same temperature for 0.5 hours, 10% hydrochloric acid was added, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure, and then the resulting residue was dissolved in 30 mL of N, N-dimethylformamide. To the solution was added 4.4 g of lithium bromide at room temperature. The reaction mixture was heated to 90C and, after stirring for 10 minutes and returning to room temperature, 10% hydrochloric acid was added, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure, and then the resulting residue was subjected to column chromatography to obtain 1.68 g of 2- bromomethyl-5-trifluoromethylpyridine.1H-NMR (CDCl3, TMS) : delta (ppm) 8.84 (IH, s), 7.94 (IH, dd) ,7.59 (IH, d) , 4,59 (2H, s). |
With phosphorus tribromide; In dichloromethane; at 0 - 20℃; for 3h; | Step (ii): 2-(Bromomethyl)-5-(trifluoromethyl)pyridine To a solution of <strong>[31181-84-7][5-(trifluoromethyl)pyridin-2-yl]methanol</strong> (5.0 g, 28.24 mmol) in DCM (50 ml) was added tribromophosphane (0.58 g, 3.50 mmol) at 0 C. The reaction was allowed to warm to room temperature and stirred for 3 hours. The reaction was then poured into water (50 ml) and the organics were extracted with DCM (2×50 ml), washed with brine, dried over sodium sulfate and concentrated in vacuo to afford the title compound which was used without further purification. MS ES+: 240, 242 | |
With phosphorus tribromide; In dichloromethane; at 20℃; for 3h; | Intermediate 1 (390.0 mg, 2.2 mmol) was dissolved in DCM (10 mL). 0 C, a solution of PBr3 (387.0 mg, 1.43 mmol) in DCM (2 mL) was added dropwise. The reaction was carried out for 3 hours at room temperature. TLC showed the reaction was completed. The pH was adjusted to 6-7 with saturated NaHCO3 solution, H2O (15 mL) added and DCM extracted (15 mLx3). The combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated to give the title compound (450.0 mg, 80.0% purity, 68.1% yield). |
[ 1956318-54-9 ]
2-(Bromomethyl)-3-(trifluoromethyl)pyridine hydrobromide
Similarity: 0.90
[ 780802-57-5 ]
2-(Bromomethyl)-3-(trifluoromethyl)pyridine
Similarity: 0.90
[ 1227606-71-4 ]
2-(Bromomethyl)-4-(trifluoromethyl)pyridine
Similarity: 0.88
[ 1806065-32-6 ]
2-(Bromomethyl)-5-(difluoromethyl)-3-methylpyridine
Similarity: 0.87
[ 31181-54-1 ]
2-Methyl-5-(trifluoromethyl)pyridine
Similarity: 0.85
[ 1956318-54-9 ]
2-(Bromomethyl)-3-(trifluoromethyl)pyridine hydrobromide
Similarity: 0.90
[ 780802-57-5 ]
2-(Bromomethyl)-3-(trifluoromethyl)pyridine
Similarity: 0.90
[ 1227606-71-4 ]
2-(Bromomethyl)-4-(trifluoromethyl)pyridine
Similarity: 0.88
[ 1806065-32-6 ]
2-(Bromomethyl)-5-(difluoromethyl)-3-methylpyridine
Similarity: 0.87
[ 1956318-54-9 ]
2-(Bromomethyl)-3-(trifluoromethyl)pyridine hydrobromide
Similarity: 0.90
[ 780802-57-5 ]
2-(Bromomethyl)-3-(trifluoromethyl)pyridine
Similarity: 0.90
[ 1227606-71-4 ]
2-(Bromomethyl)-4-(trifluoromethyl)pyridine
Similarity: 0.88
[ 31181-54-1 ]
2-Methyl-5-(trifluoromethyl)pyridine
Similarity: 0.85
[ 108274-33-5 ]
5-(Bromomethyl)-2-(trifluoromethyl)pyridine
Similarity: 0.81
[ 1956318-54-9 ]
2-(Bromomethyl)-3-(trifluoromethyl)pyridine hydrobromide
Similarity: 0.90
[ 780802-57-5 ]
2-(Bromomethyl)-3-(trifluoromethyl)pyridine
Similarity: 0.90
[ 1227606-71-4 ]
2-(Bromomethyl)-4-(trifluoromethyl)pyridine
Similarity: 0.88
[ 1806065-32-6 ]
2-(Bromomethyl)-5-(difluoromethyl)-3-methylpyridine
Similarity: 0.87
[ 31181-54-1 ]
2-Methyl-5-(trifluoromethyl)pyridine
Similarity: 0.85