[ CAS No. 1003575-43-6 ] {[proInfo.proName]}

Name: 1003575-43-6|2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline|97%
Brand: Ambeed
SKU: A212809
Price: 16.0 USD
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Quality Control of [ 1003575-43-6 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 1003575-43-6 ]

Product Details of [ 1003575-43-6 ]

CAS No. :	1003575-43-6	MDL No. :	MFCD11044430
Formula :	C₁₂H₁₇BFNO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	VXNIVUKZNDRJBW-UHFFFAOYSA-N
M.W :	237.08	Pubchem ID :	46737990
Synonyms :

Calculated chemistry of [ 1003575-43-6 ]

Physicochemical Properties

Num. heavy atoms :	17
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.5
Num. rotatable bonds :	1
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	67.28
TPSA :	44.48 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	Yes
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.09 cm/s

Lipophilicity

Log Po/w (iLOGP) :	0.0
Log Po/w (XLOGP3) :	2.33
Log Po/w (WLOGP) :	2.14
Log Po/w (MLOGP) :	1.54
Log Po/w (SILICOS-IT) :	1.53
Consensus Log Po/w :	1.51

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.97
Solubility :	0.252 mg/ml ; 0.00106 mol/l
Class :	Soluble
Log S (Ali) :	-2.9
Solubility :	0.296 mg/ml ; 0.00125 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.92
Solubility :	0.0282 mg/ml ; 0.000119 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	2.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.86

Safety of [ 1003575-43-6 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 1003575-43-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 1003575-43-6 ]
Downstream synthetic route of [ 1003575-43-6 ]

[ 1003575-43-6 ] Synthesis Path-Upstream 1~3

1
[ 1218791-09-3 ]
[ 1003575-43-6 ]

Yield	Reaction Conditions	Operation in experiment
100%	With hydrogen In ethyl acetate for 2 h; Inert atmosphere	2-Fluoro-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)aniline (14)[00198] A 500-mL Parr reactor bottle was purged with nitrogen and charged with 13 (6.92 g, 25.9 mmol), ethyl acetate (150 mL) and 10percent palladium on carbon (50percent wet, 150 mg dry weight). The bottle was attached to Parr hydrogenator, evacuated, charged with hydrogen gas to a pressure of 50 psi and shaken for 2 h. After this time the hydrogen was evacuated and nitrogen charged into the reactor. The catalyst was removed by filtration through a pad of Celite 521 and the filter cake washed with methylene chloride (400 mL). The resulting solution was concentrated under reduced pressure to afford 14 in 100percent yield (6.34 g) as a yellow oil: ¹H NMR (500 MHz, CDCl₃) 57.22 (dd, IH, /= 8.5, 1.0 Hz), 7.16 (m, IH), 6.97 (dd, IH, / = 11.5, 8.0 Hz), 3.68 (br s, 2H), 1.33 (m, 12H); MS (ESI+) m/z 238.2 (M+H).

Reference： [1] Patent: WO2010/56875, 2010, A1, . Location in patent: Page/Page column 205

2
[ 2924-09-6 ]
[ 73183-34-3 ]
[ 1003575-43-6 ]

Yield	Reaction Conditions	Operation in experiment
100%	With potassium acetate In N,N-dimethyl-formamide at 100℃; for 2 h; Inert atmosphere	A vial was charged with 5-bromo-2-fluoroaniline (1 g, 5.26 mmol), bis(pinacolato)diboron (1.6 g , 6.31 mmol), potassium acetate (1.03 g, 10.52 mmol), Pd(dppf)Cl₂ * CH₂C1₂ (129 mg, 0.158 mmol), and DMF (10 mL) under nitrogenatmosphere. After stirring for 2 h at 100 °C the reaction mixture was concentrated in vacuo, the residue was triturated with EtOAc and filtered through a pad of celite. The filtrate was adsorbed on silica gel. Purification by flash silica gel chromatography using a gradient of 0- 30percent EtOAc/hexane afforded 1.25 g of pinacol 3-amino-4-fluoroboronate as a light yellow oil (quant.): 1H NMR (CDC1₃, ppm) δ 1.36 (s, 12H), 3.71 (broad s, 2H), 7.00 (dd, 1H), 7.19 (m, 1H), 7.26 (dd, 1H); [M+H]⁺ m/z 238.

Reference： [1] Patent: WO2012/125981, 2012, A2, . Location in patent: Page/Page column 128

3
[ 2106-05-0 ]
[ 73183-34-3 ]
[ 1003575-43-6 ]

Yield	Reaction Conditions	Operation in experiment
81%	With (2,2,2-trifluoroethoxy)trimethylsilane; cesium fluoride; dichlorobis(trimethylphosphine)nickel In tetrahydrofuran at 100℃; for 12 h; Inert atmosphere; Sealed tube	Under an argon atmosphere,4.2 mg (0.015 mmol) of dichlorobis (trimethylphosphine) nickel,72.8 mg (0.5 mmol) of 5-chloro-2-fluoroaniline,152 mg (1.0 mmol) of cesium fluoride,140 mg (0.55 mmol) of 4,4,5,5,4 ', 4', 5 ', 5'-octamethyl-2,2'-bi (1,3,2-dioxaborolanyl)180 mg (1.05 mmol) of trimethyl (2,2,2-trifluoroethoxy) silane and 0.5 mL of tetrahydrofuran were added and sealed,And the mixture was stirred at 100 ° C. for 12 hours.After the reaction vessel was cooled to room temperature, 1 mL of a saturated aqueous solution of ammonium chloride was added, and the mixture was extracted three times with 8 mL of ethyl acetate, and the obtained organic phases were combined.The solvent was distilled off under reduced pressure, and the residue was purified using silica gel column chromatography (hexane: chloroform: ethyl acetate = 4: 1: 0 to 4: 1: 1)96 mg (pale yellow liquid, yield 81percent) of 2-fluoro-5- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) aniline was obtained

Reference： [1] Organic Letters, 2011, vol. 13, # 21, p. 5766 - 5769
[2] Patent: JP5699037, 2015, B2, . Location in patent: Paragraph 0105; 0106

[ 1003575-43-6 ] Synthesis Path-Downstream 1~23

1
[ 1003575-43-6 ]
[ 1003575-37-8 ]

Yield	Reaction Conditions	Operation in experiment
85%		2-Fluoro-5-(4A5,5-tetramethyl-f1 ,3,21dioxaborolan-2-yO-benzenesulfonyl chloride:A solution of NaNO2 (145 mg, 2.12 mmol) in H2O (0.3 ml) was added dropwise over 3 minutes to a precooled (0 0C) solution of 2-Fluoro-5-(4,4,5,5- tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-phenylamine (455 mg, 1.92 mmol) in concentrated aqueous HCI (0.7 ml) and glacial acetic acid (2 ml) with vigorous stirring. The resulting mixture was removed from the ice bath and allowed to warm for 15 minutes before re-cooling to 00C. Meanwhile, a blue-green solution of CuCI2 (67.2 mg, 0.5 mmol) in 0.2 ml of H2O was added in one portion to a saturated solution of SO2 in glacial acetic acid (1.7 ml) at 0 0C with vigorous stirring to produce an opaque milky-green mixture. This was carefully added to the stirred diazo solution at 0 0C to <n="77"/>produce a dark mixture with the evolution of gas. The reaction was removed from ice bath and warmed to room temperature for 1 hour before being poured into a beaker of stirred ice/water (10 ml). The grey solid was collected by filtration, washed with water (2x10 ml) and dried overnight in vacuo to give the sulfonyl chloride (430 mg, 81%). Ammonia (0.5M in dioxane, 5 equivalents) was added and the mixture was stirred overnight. Following concentration the residue was dissolved in ethyl acetate, washed with brine and evaporated. The resulting crude sulfonamide (400 mg, 85% yield) was used without further purification.

Reference： [1]Patent: WO2008/9077,2008,A2 .Location in patent: Page/Page column 74-75

2
[ 1218791-09-3 ]
[ 1003575-43-6 ]

Yield	Reaction Conditions	Operation in experiment
100%	With hydrogen;1% Pd/C; In ethyl acetate; under 2585.81 Torr; for 2h;Inert atmosphere;	2-Fluoro-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)aniline (14)[00198] A 500-mL Parr reactor bottle was purged with nitrogen and charged with 13 (6.92 g, 25.9 mmol), ethyl acetate (150 mL) and 10% palladium on carbon (50% wet, 150 mg dry weight). The bottle was attached to Parr hydrogenator, evacuated, charged with hydrogen gas to a pressure of 50 psi and shaken for 2 h. After this time the hydrogen was evacuated and nitrogen charged into the reactor. The catalyst was removed by filtration through a pad of Celite 521 and the filter cake washed with methylene chloride (400 mL). The resulting solution was concentrated under reduced pressure to afford 14 in 100% yield (6.34 g) as a yellow oil: 1H NMR (500 MHz, CDCl3) 57.22 (dd, IH, /= 8.5, 1.0 Hz), 7.16 (m, IH), 6.97 (dd, IH, / = 11.5, 8.0 Hz), 3.68 (br s, 2H), 1.33 (m, 12H); MS (ESI+) m/z 238.2 (M+H).

Reference： [1]Patent: WO2010/56875,2010,A1 .Location in patent: Page/Page column 205

3
[ 2106-05-0 ]
[ 73183-34-3 ]
[ 1003575-43-6 ]

Yield	Reaction Conditions	Operation in experiment
81%	With (2,2,2-trifluoroethoxy)trimethylsilane; cesium fluoride; dichlorobis(trimethylphosphine)nickel; In tetrahydrofuran; at 100℃; for 12h;Inert atmosphere; Sealed tube;	Under an argon atmosphere,4.2 mg (0.015 mmol) of dichlorobis (trimethylphosphine) nickel,72.8 mg (0.5 mmol) of 5-chloro-2-fluoroaniline,152 mg (1.0 mmol) of cesium fluoride,140 mg (0.55 mmol) of 4,4,5,5,4 ', 4', 5 ', 5'-octamethyl-2,2'-bi (1,3,2-dioxaborolanyl)180 mg (1.05 mmol) of trimethyl (2,2,2-trifluoroethoxy) silane and 0.5 mL of tetrahydrofuran were added and sealed,And the mixture was stirred at 100 C. for 12 hours.After the reaction vessel was cooled to room temperature, 1 mL of a saturated aqueous solution of ammonium chloride was added, and the mixture was extracted three times with 8 mL of ethyl acetate, and the obtained organic phases were combined.The solvent was distilled off under reduced pressure, and the residue was purified using silica gel column chromatography (hexane: chloroform: ethyl acetate = 4: 1: 0 to 4: 1: 1)96 mg (pale yellow liquid, yield 81%) of 2-fluoro-5- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) aniline was obtained

Reference： [1]Organic Letters,2011,vol. 13,p. 5766 - 5769
[2]Patent: JP5699037,2015,B2 .Location in patent: Paragraph 0105; 0106

4
[ 659731-48-3 ]
[ 1003575-43-6 ]
[ 1377698-27-5 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium carbonate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In 1,2-dimethoxyethane; at 100℃; for 2h;	To 5-chloro-2-fluoro-4-iodopyridine (210 mg, 0.816 mmol) was added 2-fluoro-5- (4,4,5, 5-tetramethyl-l,3,2-dioxaborolan-2-yl)aniline (271 mg, 1.142 mmol),PdC12(dppf).CH2C12 adduct (66.6 mg, 0.082 mmol), DME (3.6 ml) and then last 2M sodium carbonate (1.224 ml, 2.447 mmol). The reaction was stirred at 100 C for 2 hr and followed by LCMS. The reaction was cooled, 8 ml of ethyl acetate and 4 ml of methanol was added, filtered and concentrated to crude product. The crude was purified by silica gel chromatography using 12g column eluting with 0%-20% ethyl acetate with hexane. The desired fractions were concentrated to constant mass, giving 191 mg of the titled compound as free base used without further purification. LCMS (m/z): 241.1 (MH+), rt = 0.85 min.

Reference： [1]Patent: WO2012/66065,2012,A1 .Location in patent: Page/Page column 115

5
[ 1003575-43-6 ]
[ 1377698-32-2 ]

Reference： [1]Patent: WO2012/66065,2012,A1

6
[ 1003575-43-6 ]
5-(5-chloro-2-fluoropyridin-4-yl)-2-fluoro-N-(3-fluorobenzyl)aniline hydrochloride [ No CAS ]

Reference： [1]Patent: WO2012/66065,2012,A1

7
[ 1003575-43-6 ]
N-(trans-4-(aminomethyl)cyclohexyl)-5-chloro-4-(4-fluoro-3-(3-fluorobenzylamino)phenyl)pyridin-2-amine trifluoroacetate [ No CAS ]

Reference： [1]Patent: WO2012/66065,2012,A1

8
[ 2924-09-6 ]
[ 73183-34-3 ]
[ 1003575-43-6 ]

Yield	Reaction Conditions	Operation in experiment
100%	With potassium acetate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In N,N-dimethyl-formamide; at 100℃; for 2h;Inert atmosphere;	A vial was charged with 5-bromo-2-fluoroaniline (1 g, 5.26 mmol), bis(pinacolato)diboron (1.6 g , 6.31 mmol), potassium acetate (1.03 g, 10.52 mmol), Pd(dppf)Cl2 · CH2C12 (129 mg, 0.158 mmol), and DMF (10 mL) under nitrogenatmosphere. After stirring for 2 h at 100 C the reaction mixture was concentrated in vacuo, the residue was triturated with EtOAc and filtered through a pad of celite. The filtrate was adsorbed on silica gel. Purification by flash silica gel chromatography using a gradient of 0- 30% EtOAc/hexane afforded 1.25 g of pinacol 3-amino-4-fluoroboronate as a light yellow oil (quant.): 1H NMR (CDC13, ppm) delta 1.36 (s, 12H), 3.71 (broad s, 2H), 7.00 (dd, 1H), 7.19 (m, 1H), 7.26 (dd, 1H); [M+H]+ m/z 238.

Reference： [1]Patent: WO2012/125981,2012,A2 .Location in patent: Page/Page column 128

9
[ 1003575-43-6 ]
[ 104-12-1 ]
[ 1400220-45-2 ]

Yield	Reaction Conditions	Operation in experiment
77%	In tetrahydrofuran; at 20℃; for 22h;Inert atmosphere;	To a solution of <strong>[1003575-43-6]pinacol 3-amino-4-fluoroboronate</strong> (300 mg, 1.013 mmol) inTHF (3 mL) under nitrogen atmosphere was added 4-chlorophenylisocyanate (171 mg, 1.11 mmol). The reaction mixture was stirred at room temperature for 22 h then it was adsorbed on silica gel. Purification by flash silica gel chromatography using a gradient of 0-25%EtOAc/hexane afforded 307 mg of l-[2-fluoro-5-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan- 2-yl)-phenyl]-3-(4-chlorophenyl)-urea as a white solid (77% yield): 1H NMR (DMSO-dtf, ppm) delta 1.32 (s, 12H), 7.27 (dd, 1H), 7.35 (m, 3H), 7.51 (d, 2H), 8.52 (d, 1H), 8.62 (s, 1H), 9.24 (s, 1H); [M+H]+ m/z 391.

Reference： [1]Patent: WO2012/125981,2012,A2 .Location in patent: Page/Page column 128

Yield	Reaction Conditions	Operation in experiment
	With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; In 1,4-dioxane; at 100℃;Inert atmosphere;	General procedure: Combine 5-bromo-2-fluoro-4-methylaniline (3.1 g, 15.2 mmol), bis(pinacolato)diboron (4.24 g, 16.7 mmol), and potassium acetate (4.47 g, 45.6 mmol) in dioxane (40 mL) and sparge with argon. Add [l,l'-bis(diphenylphosphino)ferrocene]- dichloropalladium(II)-dichloromethane complex (0.620 g, 0.760 mmol), sparge again with argon and heat at 100C overnight. Filter the reaction mixture and concentrate in vacuo. Purify by silica gel chromatography (EtOAc/hexanes) to give the title compound (3.24 g, 85%). MS (m/z): 252.1 (M+ H+).

11
[ 1003575-43-6 ]
[ 1010104-22-9 ]
2-(3-amino-4-fluorophenyl)-8,9-dihydrocyclopenta[4,5]pyrrolo[2,3-f]isoquinolin-7(10H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
16%	With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In isopropyl alcohol; at 160℃; for 2.75h;Inert atmosphere; Microwave irradiation;	2-(3-amino-4-fluorophenyl)-8, 9-dihydrocyclopenta [4, 5] pyrrolo [2, 3-f isoquinolin-7 (10H)-one (2): To a stirred solution of 2-chloro-8, 9-dihydrocyclopenta [4, 5] pyrrolo [2, 3-f] isoquinolin-7 (lOH)-one 1 (300 mg, 1.17 mmol) in isopropanol (5 mL) under inert atmosphere were added 2-fluoro-5-(4,4,5,5-tetramethyl-l ,3,2-dioxaborolan-2-yl)aniline INT-41 (416 mg, 1.75 mmol) and 2N sodium carbonate solution (3 mL) at RT and purged under argon for 20 minutes. Then Pd(PPh3)2Cl2 (82 mg, 0.1 17 mmol) was added to the reaction mass and purged with argon for 20 minutes, heated to 160 C under Microwave and stirred for 45 minutes. Starting materials were not consumed by TLC and again 2-fluoro-5-(4,4,5,5- tetramethyl-l ,3,2-dioxaborolan-2-yl)aniline (138 mg, 0.58 mmol) and Pd(PPh3)2Cl2 (82 mg, 0.1 17 mmol) were added to the reaction mass and stirred at 160 C for 2 h. The reaction mixture was cooled to room temperature and filtered through celite pad, and the volatiles were evaporated under reduced pressure. The residue was purified by silica gel column chromatography to obtain 2 (60 mg, 16%) as green solid. 1H NMR (400 MHz, DMSO-d6): delta 2.93 (m, 2H), 3.24 (m, 2H), 5.30 (s, 2H), 7.18 (m, 1H), 7.32 (m, 1H), 7.72-7.75 (dd, J = 2.0, 9.2 Hz, 1H), 7.82 (d, J = 8.4 Hz, 1H), 7.91 (d, J = 8.4 Hz, 1H), 8.73 (s, 1H), 9.35 (s, 1H), 13.15 (s, 1H). MS m/z (M+H): 332.2

Reference： [1]Patent: WO2014/149164,2014,A1 .Location in patent: Paragraph 00702

12
[ 1003575-43-6 ]
[ 1454690-54-0 ]

Reference： [1]Journal of Medicinal Chemistry,2015,vol. 58,p. 4165 - 4179

13
[ 1003575-43-6 ]
1-(3,3-dimethylbutyl)-3-(2-fluoro-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2015,vol. 58,p. 4165 - 4179

14
[ 1003575-43-6 ]
[ 57933-83-2 ]
[ 1454690-52-8 ]

Reference： [1]Journal of Medicinal Chemistry,2015,vol. 58,p. 4165 - 4179

15
[ 1003575-43-6 ]
[ 1371629-97-8 ]
[ 1371630-05-5 ]

Yield	Reaction Conditions	Operation in experiment
98%	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,2-dimethoxyethane; water; at 90℃; for 1h;Inert atmosphere;	General procedure: [0156] The quinolizine scaffold (1 eq.), boronate (1.3 eq.)and cesium carbonate (3 eq.) were added to a 3:1mixture of 1,2-dimethoxyethane andwater. The mixture was degassed with argon. 1,1?-Bis-diphenylphosphineferrocene palladium(II) dichloride (0.1eq.) was added and the mixture was heated at 90 C under an argon atmosphere for 1h. The reaction mixture wascooled. The mixture was diluted with CH2Cl2 (3 mL) and water was added (3 mL). The layers were separatedusing a phase separator and the aqueous layer was extracted with CH2Cl2 (2 x 5 mL). The combined organic layerswere dried over sodium sulfate and concentrated in vacuo. The crude product was purified by flash silica column chromatographyand dried in vacuo to afford the desired product. Methyl 8-(3-amino-4-fluoro-phenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate was prepared according to General Procedure A using methyl 8-chloro-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate (100 mg, 0.34 mmol) and 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-aniline (122 mg, 0.51 mmol). Purification by flash silica column chromatography (CH2Cl2:MeOH) (1:0 to 94:6) afforded the title compound as a yellow solid (128 mg, 98%). ESI-MS m/z: 367 (M+H)+.

Reference： [1]Patent: EP3034078,2016,A1 .Location in patent: Paragraph 0156; 0196-0197

16
[ 1003575-43-6 ]
1-(2,3-dihydro-1H-inden-2-yl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine [ No CAS ]
3-(3-amino-4-fluorophenyl)-1-(2,3-dihydro-1H-inden-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine [ No CAS ]

Reference： [1]ACS Medicinal Chemistry Letters,2016,vol. 7,p. 1161 - 1166

17
[ 1003575-43-6 ]
[ 586-96-9 ]
(E)-1-(2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-phenyldiazene [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2019,vol. 58,p. 4531 - 4535
Angew. Chem.,2019,vol. 131,p. 4579 - 4583,5

18
[ 1003575-43-6 ]
4-(4-fluoro-3-(phenyldiazenyl)benzyl)-1H-imidazole [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2019,vol. 58,p. 4531 - 4535
Angew. Chem.,2019,vol. 131,p. 4579 - 4583,5

19
[ 1003575-43-6 ]
(E)-4-(4-fluoro-3-(phenyldiazenyl)benzyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2019,vol. 58,p. 4531 - 4535
Angew. Chem.,2019,vol. 131,p. 4579 - 4583,5

20
[ 1003575-43-6 ]
(E)-4-(4-fluoro-3-(phenyldiazenyl)benzyl)-1H-imidazole [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2019,vol. 58,p. 4531 - 4535
Angew. Chem.,2019,vol. 131,p. 4579 - 4583,5

21
tetrapropylammonium 2-fluorophenylsulfamate [ No CAS ]
[ 73183-34-3 ]
[ 1003575-43-6 ]
[ 819058-34-9 ]

Reference： [1]Journal of the American Chemical Society,2019,vol. 141,p. 15483 - 15487

22
[ 348-54-9 ]
[ 1003575-43-6 ]
[ 819058-34-9 ]

Reference： [1]Journal of the American Chemical Society,2019,vol. 141,p. 15483 - 15487

23
[ 1003575-43-6 ]
C₂₇H₂₆ClFN₈O₃ [ No CAS ]
4-(3-(4-(4-(3-amino-4-fluorophenyl)-6-morpholino-1,3,5-triazin-2-yl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2020

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[ 819058-34-9 ]

2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Similarity: 0.97

[ 1231892-80-0 ]

2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Similarity: 0.94

[ 1152441-29-6 ]

4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Similarity: 0.92

[ 819057-45-9 ]

3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Similarity: 0.92

[ 214360-58-4 ]

2-(4-Fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

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Amines

[ 819058-34-9 ]

2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Similarity: 0.97

[ 1231892-80-0 ]

2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Similarity: 0.94

[ 1152441-29-6 ]

4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Similarity: 0.92

[ 819057-45-9 ]

3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Similarity: 0.92

[ 1227210-37-8 ]

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 1003575-43-6 ] {[proInfo.proName]}

Quality Control of [ 1003575-43-6 ]

Related Doc. of [ 1003575-43-6 ]

Product Details of [ 1003575-43-6 ]

Calculated chemistry of [ 1003575-43-6 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 1003575-43-6 ]

Application In Synthesis of [ 1003575-43-6 ]

[ 1003575-43-6 ] Synthesis Path-Upstream 1~3

[ 1003575-43-6 ] Synthesis Path-Downstream 1~23

Related Functional Groups of [ 1003575-43-6 ]

Fluorinated Building Blocks

Organoboron

Aryls

Amines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 1003575-43-6 ]