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Chemical Structure| 1005334-57-5 Chemical Structure| 1005334-57-5

Structure of CVT-10216
CAS No.: 1005334-57-5

Chemical Structure| 1005334-57-5

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CVT 10216 is a potent and selective aldehyde dehydrogenase-2 (ALDH2) inhibitor with IC50s of 29 and 1300 nM for ALDH2 and ALDH1, respectively.

Synonyms: GS-455534

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Product Details of CVT-10216

CAS No. :1005334-57-5
Formula : C24H19NO7S
M.W : 465.48
SMILES Code : O=C2C1=CC=C(OCC4=CC(C(O)=O)=CC=C4)C=C1OC=C2C3=CC=C(NS(=O)(C)=O)C=C3
Synonyms :
GS-455534
MDL No. :MFCD18072197
InChI Key :YYOOFJZTRCPVFD-UHFFFAOYSA-N
Pubchem ID :23661666

Safety of CVT-10216

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P301+P312+P330

Isoform Comparison

Biological Activity

Description
CVT-10216 is a highly selective, reversible inhibitor of aldehyde dehydrogenase-2 (ALDH-2) with an IC50 of 29 nM. Additionally, CVT-10216 exhibits inhibitory effects on ALDH-1 with an IC50 of 1.3 μM. CVT-10216 has demonstrated the ability to decrease excessive alcohol consumption in alcohol-preferring rats and to show anxiolytic effects [1].

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Bio Calculators
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2.15mL

0.43mL

0.21mL

10.74mL

2.15mL

1.07mL

21.48mL

4.30mL

2.15mL

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