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[ CAS No. 10148-70-6 ]

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2D
Chemical Structure| 10148-70-6
Chemical Structure| 10148-70-6
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Product Details of [ 10148-70-6 ]

CAS No. :10148-70-6MDL No. :MFCD09842579
Formula : C6H13NO3 Boiling Point : -
Linear Structure Formula :-InChI Key :-
M.W :147.17Pubchem ID :6994741
Synonyms :

Computed Properties of [ 10148-70-6 ]

TPSA : 83.6 H-Bond Acceptor Count : 4
XLogP3 : - H-Bond Donor Count : 3
SP3 : 0.83 Rotatable Bond Count : 3

Safety of [ 10148-70-6 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 10148-70-6 ]

  • Upstream synthesis route of [ 10148-70-6 ]
  • Downstream synthetic route of [ 10148-70-6 ]

[ 10148-70-6 ] Synthesis Path-Upstream   1~39

  • 1
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Reference: [1] Tetrahedron Letters, 1992, vol. 33, # 45, p. 6735 - 6738
[2] Synthesis, 1990, # 1, p. 34 - 36
[3] Tetrahedron Letters, 1993, vol. 34, # 28, p. 4447 - 4448
[4] Journal of the American Chemical Society, 1996, vol. 118, # 15, p. 3584 - 3590
  • 2
  • [ 228858-51-3 ]
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YieldReaction ConditionsOperation in experiment
69% With hydrogenchloride In water at 20℃; for 3 h; A solution of 71 (22 mg, 0.11 mmol, >99:1 dr) in 6.0 M aq HCl(1 mL) was stirred at rt for 3 h, then concentrated in vacuo. H2O(4 mL) and CHCl3 (3 mL) were then added and the aqueous layerwas washed with CHCl3 (23 mL) then concentrated in vacuo.Purification via ion exchange chromatography (DOWEX 50WX8-200, eluent 1.0 M aq NH4OH) gave 72 as a white solid (11 mg, 69percent,96:4 dr);3e mp 220e226 C (dec); [a]D20 17.6 (c 1.0, H2O); {lit.3e[a]D25 20 (c 1.1, H2O)}; nmax (ATR) 3449, 3058 (OeH, NeH), 1627(C]O); dH (500 MHz, D2O) 0.89 (3H, d, J 6.7, C(4)MeA), 0.90 (3H, d, J6.7, C(4)MeB), 1.87 (1H, d septet, J 9.1, 6.7, C(4)H), 3.46 (1H, dd, J 9.1,3.2, C(3)H), 3.84 (1H, d, J 3.2, C(2)H); dC (125 MHz, CDCl3) 18.5, 18.5(C(4)Me2), 30.2 (C(4)), 57.1 (C(2)), 76.1 (C(3)),171.7 (C(1));m/z (ESI)148 ([MH], 100percent); HRMS (ESI) C6H13NNaO3 ([MNa]) requires170.0788; found 170.0788.
Reference: [1] Tetrahedron, 2015, vol. 70, # 35, p. 5849 - 5862
  • 3
  • [ 89459-98-3 ]
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Reference: [1] Journal of the American Chemical Society, 1996, vol. 118, # 15, p. 3584 - 3590
[2] Journal of the American Chemical Society, 1996, vol. 118, # 15, p. 3584 - 3590
[3] Tetrahedron Letters, 1993, vol. 34, # 28, p. 4447 - 4448
[4] Synthesis, 1990, # 1, p. 34 - 36
  • 4
  • [ 151302-40-8 ]
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Reference: [1] Journal of the American Chemical Society, 1996, vol. 118, # 15, p. 3584 - 3590
[2] Tetrahedron Letters, 1993, vol. 34, # 28, p. 4447 - 4448
  • 5
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Reference: [1] Journal of the American Chemical Society, 1996, vol. 118, # 15, p. 3584 - 3590
[2] Tetrahedron Letters, 1993, vol. 34, # 28, p. 4447 - 4448
  • 6
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Reference: [1] Organic Letters, 2004, vol. 6, # 20, p. 3541 - 3544
  • 7
  • [ 78-84-2 ]
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Reference: [1] Journal of the American Chemical Society, 1997, vol. 119, # 49, p. 11734 - 11742
[2] Tetrahedron, 2007, vol. 63, # 34, p. 8088 - 8093
  • 8
  • [ 125473-34-9 ]
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Reference: [1] Tetrahedron Letters, 1995, vol. 36, # 39, p. 7031 - 7034
[2] Tetrahedron, 1996, vol. 52, # 36, p. 11673 - 11694
  • 9
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Reference: [1] Journal of Organic Chemistry, 2009, vol. 74, # 4, p. 1627 - 1631
  • 10
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Reference: [1] Tetrahedron, 1994, vol. 50, # 30, p. 9181 - 9188
  • 11
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Reference: [1] Organic Letters, 2004, vol. 6, # 20, p. 3541 - 3544
[2] Patent: WO2006/23720, 2006, A2, . Location in patent: Page/Page column 38; 39
  • 12
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Reference: [1] Organic Letters, 2014, vol. 16, # 6, p. 1716 - 1719
  • 13
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Reference: [1] Journal of Organic Chemistry, 1998, vol. 63, # 7, p. 2382 - 2384
  • 14
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Reference: [1] Journal of Organic Chemistry, 1998, vol. 63, # 7, p. 2382 - 2384
  • 15
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Reference: [1] Tetrahedron Letters, 1993, vol. 34, # 28, p. 4447 - 4448
[2] Synthesis, 1990, # 1, p. 34 - 36
  • 16
  • [ 128053-00-9 ]
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Reference: [1] Tetrahedron Letters, 1992, vol. 33, # 45, p. 6735 - 6738
[2] Synthesis, 1990, # 1, p. 34 - 36
  • 17
  • [ 145822-80-6 ]
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Reference: [1] Tetrahedron Letters, 1992, vol. 33, # 45, p. 6735 - 6738
[2] Tetrahedron Letters, 1992, vol. 33, # 45, p. 6735 - 6738
  • 18
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Reference: [1] Organic Letters, 2002, vol. 4, # 11, p. 1883 - 1886
  • 19
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Reference: [1] Tetrahedron, 1994, vol. 50, # 30, p. 9181 - 9188
  • 20
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Reference: [1] Tetrahedron, 1994, vol. 50, # 30, p. 9181 - 9188
  • 21
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Reference: [1] Tetrahedron, 1994, vol. 50, # 30, p. 9181 - 9188
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Reference: [1] Tetrahedron, 1994, vol. 50, # 30, p. 9181 - 9188
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Reference: [1] Tetrahedron Letters, 1992, vol. 33, # 45, p. 6735 - 6738
  • 24
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Reference: [1] Tetrahedron Asymmetry, 2001, vol. 12, # 12, p. 1757 - 1762
  • 25
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Reference: [1] Tetrahedron Asymmetry, 2001, vol. 12, # 12, p. 1757 - 1762
  • 26
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Reference: [1] Tetrahedron Asymmetry, 2001, vol. 12, # 12, p. 1757 - 1762
  • 27
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Reference: [1] Tetrahedron Asymmetry, 2008, vol. 19, # 24, p. 2816 - 2828
  • 28
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Reference: [1] Journal of Organic Chemistry, 1998, vol. 63, # 7, p. 2382 - 2384
  • 29
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Reference: [1] Tetrahedron, 1996, vol. 52, # 36, p. 11673 - 11694
  • 30
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Reference: [1] Tetrahedron, 1996, vol. 52, # 36, p. 11673 - 11694
  • 31
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Reference: [1] Tetrahedron, 1996, vol. 52, # 36, p. 11673 - 11694
  • 32
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Reference: [1] Tetrahedron, 1996, vol. 52, # 36, p. 11673 - 11694
  • 33
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Reference: [1] Tetrahedron, 1996, vol. 52, # 36, p. 11673 - 11694
  • 34
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Reference: [1] Tetrahedron Asymmetry, 2001, vol. 12, # 12, p. 1757 - 1762
  • 35
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Reference: [1] Tetrahedron, 2015, vol. 70, # 35, p. 5849 - 5862
  • 36
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Reference: [1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 24, p. 3577 - 3578
  • 37
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Reference: [1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 24, p. 3577 - 3578
  • 38
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Reference: [1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 24, p. 3577 - 3578
  • 39
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Reference: [1] Angewandte Chemie, 1994, vol. 106, # 1, p. 106 - 108
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