* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With ammonium hydroxide; oxygen; copper diacetate; In ethyl acetate; acetone; at 60℃; under 1875.19 Torr; for 0.05h;
(1) 400 g of diphenyl thiourea, 0.5 g of catalyst copper acetate and 372 mL of concentration 24wt.% ammonia water, Then, the slurry is mixed with 3500 mL of a mixed solvent of acetone and ethyl acetate (volume ratio of acetone to ethyl acetate of 3:1) under stirring to obtain a reaction raw material mixture; (2) The reaction raw material mixture and oxygen are 2.9 mL/min according to the raw material mixture. oxygen gas flow rate of 14.3mL / min into the microchannel reactor for oxidation reaction, Reaction temperature 60 C, The residence time is 3 min, and the reaction pressure is 0.25 MPa; The microchannel reactor is 10 pieces in series. The volume of the single piece is 1.86 mL, and the full volume is 18.6 mL; (3) The product solution obtained by the reaction is subjected to distillation under reduced pressure to recover an organic solvent, and the obtained solid material is subjected to alkali washing, washing with water, and drying to obtain a vulcanization accelerator DPG.According to the calculation, the DPG yield of this example was 96.1% (calculated as CA dosage), and the appearance was white microcrystalline powder.
90%
With ammonia; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In water; acetonitrile; at 20℃;
General procedure: Method A: To a stirred solution of 1,3-disubstituted thiourea (5 mmol) in acetonitrile (10 mL) was added drop wise a solution of IBX (5.5 mmol), in aqueous ammonia (10 mL of a 28-30% solution) at rt over a period of 10 min. After completion of reaction as analysed by TLC (reaction time 30 min) the mixture was extracted with (2 × 15 mL) ethyl acetate. The organic layer was washed with 10% aqueous sodium bicarbonate solution (2 × 15 mL), evaporated and chromatographed to afford the pure product.
EXAMPLE 3; 2.11 g (0.01 mol) of 1 ,3-<strong>[102-06-7]diphenylguanidine</strong> was dissolved in 100 ml_ of anhydrous THF and charged into a two-neck flask with magnetic stirrer under argon. A solution of 2.81 g (0.01 mol) trifluoromethanesulfonimide in 5OmL of anhydrous THF was slowly added into the flask under argon. After ten minutes of stirring at room temperature, the solvent was removed under vacuum and the crude product was dissolved in 50 mL of CH2CI2 and extracted with 3 times with 50 mL of distilled water. The organic layer was dried with a small amount of anhydrous MgSO4 and filtered off. The solvent was removed and the desired product obtained was dried under vacuum.The structure was confirmed using 13C, 1H and IR
In ethanol; water mixing aq. soln. of NdCl3 with ethanolic soln. of β-diketone and aq. soln. of org. base in presence of acetate ammonia buffer or urotropin with pH 7.5 (molar ratio 1:5:10); not isolated;
With nitric acid; In methanesulfonic acid; at 20℃; for 6.0h;
The title compound was synthesized by mixing equimolar portions of N,N'-Diphenylguanidine and nitric acid using methanol as solvent. At first the starting material, nitric acid was dissolved in methanol and then further N,N'-Diphenylguanidine was added tothis solution, by continuous stirring, until complete neutralization occurred resulting in a pale brown colored solution. The solution was made to stir for 6 h using a magnetic stirrer in order to achieve homogeneity at room temperature and the resulting solution was filtered in a 500 mL clean borosil beaker through Whatmann filter paper. The beaker was covered with aluminum foil in order to control the rate of evaporation. The purity of the synthesized salt was further improved by successive recrystallization. The reaction scheme is given in Fig. 1. A well defined pale brown colored transparent single crystal of DPGN was harvested after a period of 46 days and the photograph of the as grown DPGN crystal is shown in Fig. 2.
N-phenyl-N-(N-phenylcarbamimidoyl)acetamide[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
In acetonitrile; at 20℃;
Diphenylguanidine (10 mmol, 2.11 g) was dissolved in 30 mL acetonitrile. Acetic anhydride (5 mmol) dissolved in acetonitrile (20 mL) was slowly added to the mixture and stirred overnight at room temperature. The reaction mixture was extracted with ethyl acetate. The organic layer was washed with water and brine and dried over Na2SO4. Removal of solvent by evaporation in vacuo followed by purification with column chromatography on silica gel provided the desired products.
With carbon monoxide; palladium dichloride; In benzonitrile; at 120℃; under 760.051 Torr;
General procedure: To a screw-cap reaction tube was added symmetrical N,N?-disubstituted guanidines 1a (0.2 mmol), PdCl2 (5 mol%, 1.8 mg), CuX2 (0.44 mmol). The reaction tube was evacuated and back-filled with CO (three times, balloon). PhCN (2 mL) was added using a syringe and the mixture was heated to the desired temperature with use of an oil bath. When the reaction was completed (detected by TLC), the mixture was cooled to room temperature and vented to discharge the excess CO. After the reaction was completed, the solvent was concentrated by evaporation in vacuo. The residue was purified by flash column chromatography on silica gel to afford the desired product Amides 6a with petroleum ether/ethyl acetate as the eluent.
With carbon monoxide; palladium dichloride; In benzonitrile; at 120℃; under 760.051 Torr;
General procedure: To a screw-cap reaction tube was added symmetrical N,N?-disubstituted guanidines 1a (0.2 mmol), PdCl2 (5 mol%, 1.8 mg), CuX2 (0.44 mmol). The reaction tube was evacuated and back-filled with CO (three times, balloon). PhCN (2 mL) was added using a syringe and the mixture was heated to the desired temperature with use of an oil bath. When the reaction was completed (detected by TLC), the mixture was cooled to room temperature and vented to discharge the excess CO. After the reaction was completed, the solvent was concentrated by evaporation in vacuo. The residue was purified by flash column chromatography on silica gel to afford the desired product Amides 6a with petroleum ether/ethyl acetate as the eluent.
With carbon monoxide; palladium dichloride; In benzonitrile; at 120℃; under 760.051 Torr;
General procedure: To a screw-cap reaction tube was added symmetrical N,N?-disubstituted guanidines 1a (0.2 mmol), PdCl2 (5 mol%, 1.8 mg), CuX2 (0.44 mmol). The reaction tube was evacuated and back-filled with CO (three times, balloon). PhCN (2 mL) was added using a syringe and the mixture was heated to the desired temperature with use of an oil bath. When the reaction was completed (detected by TLC), the mixture was cooled to room temperature and vented to discharge the excess CO. After the reaction was completed, the solvent was concentrated by evaporation in vacuo. The residue was purified by flash column chromatography on silica gel to afford the desired product Amides 6a with petroleum ether/ethyl acetate as the eluent.
With carbon monoxide; palladium dichloride; In benzonitrile; at 120℃; under 760.051 Torr;
General procedure: To a screw-cap reaction tube was added symmetrical N,N?-disubstituted guanidines 1a (0.2 mmol), PdCl2 (5 mol%, 1.8 mg), CuX2 (0.44 mmol). The reaction tube was evacuated and back-filled with CO (three times, balloon). PhCN (2 mL) was added using a syringe and the mixture was heated to the desired temperature with use of an oil bath. When the reaction was completed (detected by TLC), the mixture was cooled to room temperature and vented to discharge the excess CO. After the reaction was completed, the solvent was concentrated by evaporation in vacuo. The residue was purified by flash column chromatography on silica gel to afford the desired product Amides 6a with petroleum ether/ethyl acetate as the eluent.
With carbon monoxide; palladium dichloride; In benzonitrile; at 120℃; under 760.051 Torr;
General procedure: To a screw-cap reaction tube was added symmetrical N,N?-disubstituted guanidines 1a (0.2 mmol), PdCl2 (5 mol%, 1.8 mg), CuX2 (0.44 mmol). The reaction tube was evacuated and back-filled with CO (three times, balloon). PhCN (2 mL) was added using a syringe and the mixture was heated to the desired temperature with use of an oil bath. When the reaction was completed (detected by TLC), the mixture was cooled to room temperature and vented to discharge the excess CO. After the reaction was completed, the solvent was concentrated by evaporation in vacuo. The residue was purified by flash column chromatography on silica gel to afford the desired product Amides 6a with petroleum ether/ethyl acetate as the eluent.
With carbon monoxide; palladium diacetate; In benzonitrile; at 120℃; under 760.051 Torr;
General procedure: To a screw-cap reaction tube was added symmetrical N,N?-disubstituted guanidines 1a (0.2 mmol), Pd(OAc)2 (5 mol%, 2.2 mg), Cu(OAc)2 (0.2 mmol, 36.3 mg). The reaction tube was evacuated and back-filled with CO (three times, balloon). MeCN (2mL) was added using a syringe and the mixture was heated to the desired temperature with use of an oil bath. When the reaction was completed (detected by TLC), the mixture was cooled to room temperature and vented to discharge the excess CO. The solvent was concentrated by evaporation in vacuo. The residue was purified by flash column chromatography on silica gel to afford the desired product amides 2a with petroleum ether/ethyl acetate as the eluent.
With choline chloride; triethylamine; glycerol; at 80℃;Green chemistry;
General procedure: The appropriate alpha-chloroketone 1 (1.0 mmol), guanidine 2a (1.3 mmol) and Et3N (1 mmol) wereadded to the ChCl-Gly eutectic mixture (2 g) under magnetic stirring, and the mixture was then heatedto 80 C for a period of 4-6 h, until the ketone 1 disappeared, as revealed by GC-MS analysis. After thistime, the mixture was cooled to room temperature and 5 mL of H2O were added. The resulting aqueoussuspension was then extracted with AcOEt (3 x 10 mL). The combined organic phases were driedover Na2SO4 and concentrated in vacuo. The crude product was purified by flash-chromatography(silica gel; petroleum ether/AcOEt 80:20-95:5) to give the desired aminoimidazoles 3a-g.
5-tert-butyl-N,1-diphenyl-1H-imidazol-2-amine[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
74%
With choline chloride; triethylamine; glycerol; at 80℃;Green chemistry;
General procedure: The appropriate alpha-chloroketone 1 (1.0 mmol), guanidine 2a (1.3 mmol) and Et3N (1 mmol) wereadded to the ChCl-Gly eutectic mixture (2 g) under magnetic stirring, and the mixture was then heatedto 80 C for a period of 4-6 h, until the ketone 1 disappeared, as revealed by GC-MS analysis. After thistime, the mixture was cooled to room temperature and 5 mL of H2O were added. The resulting aqueoussuspension was then extracted with AcOEt (3 x 10 mL). The combined organic phases were driedover Na2SO4 and concentrated in vacuo. The crude product was purified by flash-chromatography(silica gel; petroleum ether/AcOEt 80:20-95:5) to give the desired aminoimidazoles 3a-g.
With choline chloride; triethylamine; glycerol; at 80℃;Green chemistry;
General procedure: The appropriate alpha-chloroketone 1 (1.0 mmol), guanidine 2a (1.3 mmol) and Et3N (1 mmol) wereadded to the ChCl-Gly eutectic mixture (2 g) under magnetic stirring, and the mixture was then heatedto 80 C for a period of 4-6 h, until the ketone 1 disappeared, as revealed by GC-MS analysis. After thistime, the mixture was cooled to room temperature and 5 mL of H2O were added. The resulting aqueoussuspension was then extracted with AcOEt (3 x 10 mL). The combined organic phases were driedover Na2SO4 and concentrated in vacuo. The crude product was purified by flash-chromatography(silica gel; petroleum ether/AcOEt 80:20-95:5) to give the desired aminoimidazoles 3a-g.
N,1-diphenyl-5-p-tolyl-1H-imidazol-2-amine[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
80%
With choline chloride; triethylamine; glycerol; at 80℃;Green chemistry;
General procedure: The appropriate alpha-chloroketone 1 (1.0 mmol), guanidine 2a (1.3 mmol) and Et3N (1 mmol) wereadded to the ChCl-Gly eutectic mixture (2 g) under magnetic stirring, and the mixture was then heatedto 80 C for a period of 4-6 h, until the ketone 1 disappeared, as revealed by GC-MS analysis. After thistime, the mixture was cooled to room temperature and 5 mL of H2O were added. The resulting aqueoussuspension was then extracted with AcOEt (3 x 10 mL). The combined organic phases were driedover Na2SO4 and concentrated in vacuo. The crude product was purified by flash-chromatography(silica gel; petroleum ether/AcOEt 80:20-95:5) to give the desired aminoimidazoles 3a-g.
5-(4-methoxyphenyl)-N,1-diphenyl-1H-imidazol-2-amine[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
79%
With choline chloride; triethylamine; glycerol; at 80℃;Green chemistry;
General procedure: The appropriate alpha-chloroketone 1 (1.0 mmol), guanidine 2a (1.3 mmol) and Et3N (1 mmol) wereadded to the ChCl-Gly eutectic mixture (2 g) under magnetic stirring, and the mixture was then heatedto 80 C for a period of 4-6 h, until the ketone 1 disappeared, as revealed by GC-MS analysis. After thistime, the mixture was cooled to room temperature and 5 mL of H2O were added. The resulting aqueoussuspension was then extracted with AcOEt (3 x 10 mL). The combined organic phases were driedover Na2SO4 and concentrated in vacuo. The crude product was purified by flash-chromatography(silica gel; petroleum ether/AcOEt 80:20-95:5) to give the desired aminoimidazoles 3a-g.
5-(4-chlorophenyl)-N,1-diphenyl-1H-imidazol-2-amine[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
80%
With choline chloride; triethylamine; glycerol; at 80℃;Green chemistry;
General procedure: The appropriate alpha-chloroketone 1 (1.0 mmol), guanidine 2a (1.3 mmol) and Et3N (1 mmol) wereadded to the ChCl-Gly eutectic mixture (2 g) under magnetic stirring, and the mixture was then heatedto 80 C for a period of 4-6 h, until the ketone 1 disappeared, as revealed by GC-MS analysis. After thistime, the mixture was cooled to room temperature and 5 mL of H2O were added. The resulting aqueoussuspension was then extracted with AcOEt (3 x 10 mL). The combined organic phases were driedover Na2SO4 and concentrated in vacuo. The crude product was purified by flash-chromatography(silica gel; petroleum ether/AcOEt 80:20-95:5) to give the desired aminoimidazoles 3a-g.
5-(4-fluorophenyl)-N,1-diphenyl-1H-imidazol-2-amine[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
83%
With choline chloride; triethylamine; glycerol; at 80℃;Green chemistry;
General procedure: The appropriate alpha-chloroketone 1 (1.0 mmol), guanidine 2a (1.3 mmol) and Et3N (1 mmol) wereadded to the ChCl-Gly eutectic mixture (2 g) under magnetic stirring, and the mixture was then heatedto 80 C for a period of 4-6 h, until the ketone 1 disappeared, as revealed by GC-MS analysis. After thistime, the mixture was cooled to room temperature and 5 mL of H2O were added. The resulting aqueoussuspension was then extracted with AcOEt (3 x 10 mL). The combined organic phases were driedover Na2SO4 and concentrated in vacuo. The crude product was purified by flash-chromatography(silica gel; petroleum ether/AcOEt 80:20-95:5) to give the desired aminoimidazoles 3a-g.
0.3Eu(3+)*0.7Gd(3+)*3C2F3O2(1-)*C13H13N3*2H2O[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
With ammonium hydroxide; In ethanol; water;pH 7 - 7.5;
General procedure: To prepare mixed-metal trifluoroacetates of the composition Eu1-xGdx(C2F3O2)3*yD*zH2O, where x 0, 0.25, 0.5, or 0.7, we used the following reagents: europium(III) chloride hexahydrate, gadolinium(III) chloride hexahydrate, trifluoroacetic acid and neutral ligand (1,10-phenanthroline, 2,2-dipyridil, <strong>[102-06-7]diphenylguanidine</strong>). The synthetic procedure was the following: 3 mmol trifluoroacetic acid and 1-2 mmol neutral ligand (1,10-phenanthroline, 2,2-dipyridil, <strong>[102-06-7]diphenylguanidine</strong>) in 50 ml 96% - ethanole was added to an aqueous solution of gadolinium chloride hexahydrate, and europium chloride hexahydrate. pH was adjusted to 7-7.5 by 10% aqueous ammonia. The reaction mixture was allowed to stand until precipitation occurred. The precipitate was filtered, washed with water, and air dried. The yield of mixed-metal compounds was 80-84%.
0.25Eu(3+)*0.75Gd(3+)*3C2F3O2(1-)*C13H13N3*2H2O[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
With ammonium hydroxide; In ethanol; water;pH 7 - 7.5;
General procedure: To prepare mixed-metal trifluoroacetates of the composition Eu1-xGdx(C2F3O2)3*yD*zH2O, where x 0, 0.25, 0.5, or 0.7, we used the following reagents: europium(III) chloride hexahydrate, gadolinium(III) chloride hexahydrate, trifluoroacetic acid and neutral ligand (1,10-phenanthroline, 2,2-dipyridil, <strong>[102-06-7]diphenylguanidine</strong>). The synthetic procedure was the following: 3 mmol trifluoroacetic acid and 1-2 mmol neutral ligand (1,10-phenanthroline, 2,2-dipyridil, <strong>[102-06-7]diphenylguanidine</strong>) in 50 ml 96% - ethanole was added to an aqueous solution of gadolinium chloride hexahydrate, and europium chloride hexahydrate. pH was adjusted to 7-7.5 by 10% aqueous ammonia. The reaction mixture was allowed to stand until precipitation occurred. The precipitate was filtered, washed with water, and air dried. The yield of mixed-metal compounds was 80-84%.
0.5Eu(3+)*0.5Gd(3+)*3C2F3O2(1-)*C13H13N3*2H2O[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
With ammonium hydroxide; In ethanol; water;pH 7 - 7.5;
General procedure: To prepare mixed-metal trifluoroacetates of the composition Eu1-xGdx(C2F3O2)3*yD*zH2O, where x 0, 0.25, 0.5, or 0.7, we used the following reagents: europium(III) chloride hexahydrate, gadolinium(III) chloride hexahydrate, trifluoroacetic acid and neutral ligand (1,10-phenanthroline, 2,2-dipyridil, <strong>[102-06-7]diphenylguanidine</strong>). The synthetic procedure was the following: 3 mmol trifluoroacetic acid and 1-2 mmol neutral ligand (1,10-phenanthroline, 2,2-dipyridil, <strong>[102-06-7]diphenylguanidine</strong>) in 50 ml 96% - ethanole was added to an aqueous solution of gadolinium chloride hexahydrate, and europium chloride hexahydrate. pH was adjusted to 7-7.5 by 10% aqueous ammonia. The reaction mixture was allowed to stand until precipitation occurred. The precipitate was filtered, washed with water, and air dried. The yield of mixed-metal compounds was 80-84%.
With ammonium hydroxide; In ethanol; water;pH 7 - 7.5;
General procedure: To prepare mixed-metal trifluoroacetates of the composition Eu1-xGdx(C2F3O2)3*yD*zH2O, where x 0, 0.25, 0.5, or 0.7, we used the following reagents: europium(III) chloride hexahydrate, gadolinium(III) chloride hexahydrate, trifluoroacetic acid and neutral ligand (1,10-phenanthroline, 2,2-dipyridil, <strong>[102-06-7]diphenylguanidine</strong>). The synthetic procedure was the following: 3 mmol trifluoroacetic acid and 1-2 mmol neutral ligand (1,10-phenanthroline, 2,2-dipyridil, <strong>[102-06-7]diphenylguanidine</strong>) in 50 ml 96% - ethanole was added to an aqueous solution of gadolinium chloride hexahydrate, and europium chloride hexahydrate. pH was adjusted to 7-7.5 by 10% aqueous ammonia. The reaction mixture was allowed to stand until precipitation occurred. The precipitate was filtered, washed with water, and air dried. The yield of mixed-metal compounds was 80-84%.
General procedure: A mixture of the corresponding guanidine or guanidine carbonate (0.01 mol) andthe corresponding acid (0.01 mol) in absolute methanol (10 ml) wasstirred at 20-65C for 1-3 h (in the cases of carbonates, CO2 gassing wasobserved). The solvent was distilled off, and the residue was multiplywashed with diethyl ether and dried (24 h) over P2O5 at ~0.01 Torr toafford the powders.For 8: yield 92%, colourless powder, mp 136C. IR (KBr, n/cm-1):3401 (NH), 1667 (C=N), 1566 (C=O). 1H NMR (D2O) d: 3.46 (s, 2H,SCH2), 7.11-712 (m, 4H, C6H4). 13C NMR (D2O) d: 38.31 (SCH2),128.97-134.00 (C6H4), 157.86 (C=N), 176.72 (C=O). Found (%): C, 41.41;H, 4.51; N, 16.06. Calc. for C9H12ClN3O2S (%): C, 41.30; H, 4.61; N, 16.05.
General procedure: A mixture of the corresponding guanidine or guanidine carbonate (0.01 mol) andthe corresponding acid (0.01 mol) in absolute methanol (10 ml) wasstirred at 20-65C for 1-3 h (in the cases of carbonates, CO2 gassing wasobserved). The solvent was distilled off, and the residue was multiplywashed with diethyl ether and dried (24 h) over P2O5 at ~0.01 Torr toafford the powders.For 8: yield 92%, colourless powder, mp 136C. IR (KBr, n/cm-1):3401 (NH), 1667 (C=N), 1566 (C=O). 1H NMR (D2O) d: 3.46 (s, 2H,SCH2), 7.11-712 (m, 4H, C6H4). 13C NMR (D2O) d: 38.31 (SCH2),128.97-134.00 (C6H4), 157.86 (C=N), 176.72 (C=O). Found (%): C, 41.41;H, 4.51; N, 16.06. Calc. for C9H12ClN3O2S (%): C, 41.30; H, 4.61; N, 16.05.
With platinum(II) acetylacetonate; 1-carboxyethyl-3-methylimidazolium hydrogen bisulfate; zinc diacetate; copper(II) bis(trifluoromethanesulfonate); at 50℃; for 8.0h;
At room temperature,To the appropriate amount of organic solvent isophthalonitrile,100 mmol of the compound of formula (I)150 mmol of the compound of formula (II)2 mmol of catalyst acetylacetone platinum,200 mmol of auxiliaries (mixed with 50 mmol of copper trifluoromethanesulfonate with 150 mmol of zinc acetate) ) And 20 mmol of 1-carboxyethyl-3-methylimidazolium bisulfate,Then heated to 50 C,And the reaction was stirred at that temperature for 8 hours.After the reaction,Hot filter,Then, Na2S saturated aqueous solution was added to the filtrate, Fully washed,The organic phase was separated,Anhydrous magnesium sulfate filter,Vacuum concentration,The resulting residue was subjected to 200-300 mesh silica gel column chromatography,A mixture of ethyl acetate and acetone in an equal volume ratio was used as the eluent,To give the compound of formula (III) in a yield of 96.8%.
N,N’-diphenylguanidinium picrate diacetone[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
at 20℃; for 6.0h;
Equimolar methanolic solutions of picric acid (Analytical grade-Sigma Aldrich) and N,N'-<strong>[102-06-7]diphenylguanidine</strong> (Analytical grade-TCI chemicals) were mixed and the resulting solution was stirred well at room temperature for 6 h. A yellow colour precipitate was obtained after evaporation of the solvent. The precipitate was repeatedly recrystallized in acetone. Transparent and yellow coloured single crystals of N,N?-diphenylguanidinium picrate: diacetone solvate (DPGPD) were harvested after 20 days by slow evaporation-solution growth technique
N,N'-diphenylguanidinium p-toluenesulphonate[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
In methanol; at 30℃; for 6.0h;
Equimolar ratio of N,N'-<strong>[102-06-7]diphenylguanidine</strong> (Analytical Grade-Sigma Aldrich) and p-toluenesulphonic acid (Analytical Grade-Sigma Aldrich) were dissolved in methanol separately and the mixture was stirred well for 6 hrs at 30 C. The resultant solution was filtered in order to remove the impurities and a clear homogenous solution left undisturbed in a covered vessel for slow evaporation technique at ambient temperature. After 30 days,bright transparent crystals of DPGPTS were harvested and the photographic image is provided in Fig. S1. The reaction scheme is shown below.
N,N′ -diphenylguanidinium 3,5-dichlorobenzoate[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
In methanol; for 5.0h;
DPGCB was prepared by mixing a 1:1 ratio of N,N?-<strong>[102-06-7]diphenylguanidine</strong> and 3,5-dichlorobenzoic acid, using methanol as a solvent. The homogeneous-saturated solution was stirred well for 5 hr and the filtrate was kept in a glass beaker covered with a perforated aluminum foil forthe growth of pure single crystals of DPGCB at room temperature.optically transparent crystals harvested after 25 days were recrystallized using acetone solvent to enhance their optical quality. The formation of DPGCB is shown in the scheme below.
General procedure: 10 mmol of all metal chlorides including iron (III) chloride hexahydrate,iron(II) chloride tetrahydrate, copper(II) chloride, zinc(II) chloride,tin(II) chloride were dissolved in 50 mL acetone separately.10 mmol of each ligand i.e. 1,3-Diphenylguanidine (DPG) (2.11 g), and1,5-Diphenylcarbazide (DPC) (2.42 g) were also dissolved in 50 mL acetoneseparately. Then, each ligand solution was added to each metalchloride solutions drop by drop and stirred for 15 min in order toform Cu(II)-(DPG), Fe(III)-(DPG), Fe(II)-(DPG), Zn(II)-(DPG), Sn(II)-(DPG), Cu(II)-(DPC), Fe(III)-(DPC), Fe(II)-(DPC), Zn(II)-(DPC), Sn(II)-(DPC). The obtained metal complexes (MC) were insoluble in acetoneand precipitated in the medium. The precipitated complexes were filteredand washed with acetone for several times and then, were dried in vacuum desiccator. One mole of choline chloride as hydrogen bondacceptor and 1 mol of MC as hydrogen bond donors were mixed andstirred for 4 h at 80 C in oil bath, and a homogeneous and transparentliquid was obtained for each metal.
General procedure: 10 mmol of all metal chlorides including iron (III) chloride hexahydrate,iron(II) chloride tetrahydrate, copper(II) chloride, zinc(II) chloride,tin(II) chloride were dissolved in 50 mL acetone separately.10 mmol of each ligand i.e. 1,3-Diphenylguanidine (DPG) (2.11 g), and1,5-Diphenylcarbazide (DPC) (2.42 g) were also dissolved in 50 mL acetoneseparately. Then, each ligand solution was added to each metalchloride solutions drop by drop and stirred for 15 min in order toform Cu(II)-(DPG), Fe(III)-(DPG), Fe(II)-(DPG), Zn(II)-(DPG), Sn(II)-(DPG), Cu(II)-(DPC), Fe(III)-(DPC), Fe(II)-(DPC), Zn(II)-(DPC), Sn(II)-(DPC). The obtained metal complexes (MC) were insoluble in acetoneand precipitated in the medium. The precipitated complexes were filteredand washed with acetone for several times and then, were dried in vacuum desiccator. One mole of choline chloride as hydrogen bondacceptor and 1 mol of MC as hydrogen bond donors were mixed andstirred for 4 h at 80 C in oil bath, and a homogeneous and transparentliquid was obtained for each metal.
General procedure: 10 mmol of all metal chlorides including iron (III) chloride hexahydrate,iron(II) chloride tetrahydrate, copper(II) chloride, zinc(II) chloride,tin(II) chloride were dissolved in 50 mL acetone separately.10 mmol of each ligand i.e. 1,3-Diphenylguanidine (DPG) (2.11 g), and1,5-Diphenylcarbazide (DPC) (2.42 g) were also dissolved in 50 mL acetoneseparately. Then, each ligand solution was added to each metalchloride solutions drop by drop and stirred for 15 min in order toform Cu(II)-(DPG), Fe(III)-(DPG), Fe(II)-(DPG), Zn(II)-(DPG), Sn(II)-(DPG), Cu(II)-(DPC), Fe(III)-(DPC), Fe(II)-(DPC), Zn(II)-(DPC), Sn(II)-(DPC). The obtained metal complexes (MC) were insoluble in acetoneand precipitated in the medium. The precipitated complexes were filteredand washed with acetone for several times and then, were dried in vacuum desiccator. One mole of choline chloride as hydrogen bondacceptor and 1 mol of MC as hydrogen bond donors were mixed andstirred for 4 h at 80 C in oil bath, and a homogeneous and transparentliquid was obtained for each metal.
General procedure: 10 mmol of all metal chlorides including iron (III) chloride hexahydrate,iron(II) chloride tetrahydrate, copper(II) chloride, zinc(II) chloride,tin(II) chloride were dissolved in 50 mL acetone separately.10 mmol of each ligand i.e. 1,3-Diphenylguanidine (DPG) (2.11 g), and1,5-Diphenylcarbazide (DPC) (2.42 g) were also dissolved in 50 mL acetoneseparately. Then, each ligand solution was added to each metalchloride solutions drop by drop and stirred for 15 min in order toform Cu(II)-(DPG), Fe(III)-(DPG), Fe(II)-(DPG), Zn(II)-(DPG), Sn(II)-(DPG), Cu(II)-(DPC), Fe(III)-(DPC), Fe(II)-(DPC), Zn(II)-(DPC), Sn(II)-(DPC). The obtained metal complexes (MC) were insoluble in acetoneand precipitated in the medium. The precipitated complexes were filteredand washed with acetone for several times and then, were dried in vacuum desiccator. One mole of choline chloride as hydrogen bondacceptor and 1 mol of MC as hydrogen bond donors were mixed andstirred for 4 h at 80 C in oil bath, and a homogeneous and transparentliquid was obtained for each metal.
General procedure: 10 mmol of all metal chlorides including iron (III) chloride hexahydrate,iron(II) chloride tetrahydrate, copper(II) chloride, zinc(II) chloride,tin(II) chloride were dissolved in 50 mL acetone separately.10 mmol of each ligand i.e. 1,3-Diphenylguanidine (DPG) (2.11 g), and1,5-Diphenylcarbazide (DPC) (2.42 g) were also dissolved in 50 mL acetoneseparately. Then, each ligand solution was added to each metalchloride solutions drop by drop and stirred for 15 min in order toform Cu(II)-(DPG), Fe(III)-(DPG), Fe(II)-(DPG), Zn(II)-(DPG), Sn(II)-(DPG), Cu(II)-(DPC), Fe(III)-(DPC), Fe(II)-(DPC), Zn(II)-(DPC), Sn(II)-(DPC). The obtained metal complexes (MC) were insoluble in acetoneand precipitated in the medium. The precipitated complexes were filteredand washed with acetone for several times and then, were dried in vacuum desiccator. One mole of choline chloride as hydrogen bondacceptor and 1 mol of MC as hydrogen bond donors were mixed andstirred for 4 h at 80 C in oil bath, and a homogeneous and transparentliquid was obtained for each metal.
With potassium hydroxide; In dimethyl sulfoxide; at 130℃; for 36.0h;Sealed tube; Inert atmosphere;
General procedure: To a mixture of iodobenzene (1.0 mmol), guanidine nitrate(0.5 mmol), and KOH (3.0 mmol) in DMSO (2 mL), Cu/Cu2O (25 mg)was added. The resulting mixture was then sealed and stirred for 36 h at130 C. After completion of the reaction, the reaction mixture wascooled to room temperature, diluted with water followed by extractionusing ethyl acetate. The organic phase was dried over anhydrousNa2SO4. The crude residue was obtained after evaporation of the solventon rotavapor. The residue was purified by column chromatographywith ethyl acetate and pet-ether as eluent to give the pure product.
With potassium hydroxide; In dimethyl sulfoxide; at 130℃; for 36.0h;Sealed tube; Inert atmosphere;
General procedure: To a mixture of iodobenzene (1.0 mmol), guanidine nitrate(0.5 mmol), and KOH (3.0 mmol) in DMSO (2 mL), Cu/Cu2O (25 mg)was added. The resulting mixture was then sealed and stirred for 36 h at130 C. After completion of the reaction, the reaction mixture wascooled to room temperature, diluted with water followed by extractionusing ethyl acetate. The organic phase was dried over anhydrousNa2SO4. The crude residue was obtained after evaporation of the solventon rotavapor. The residue was purified by column chromatographywith ethyl acetate and pet-ether as eluent to give the pure product.
With potassium hydroxide; In dimethyl sulfoxide; at 130℃; for 36.0h;Sealed tube; Inert atmosphere;
General procedure: To a mixture of iodobenzene (1.0 mmol), guanidine nitrate(0.5 mmol), and KOH (3.0 mmol) in DMSO (2 mL), Cu/Cu2O (25 mg)was added. The resulting mixture was then sealed and stirred for 36 h at130 C. After completion of the reaction, the reaction mixture wascooled to room temperature, diluted with water followed by extractionusing ethyl acetate. The organic phase was dried over anhydrousNa2SO4. The crude residue was obtained after evaporation of the solventon rotavapor. The residue was purified by column chromatographywith ethyl acetate and pet-ether as eluent to give the pure product.
With potassium hydroxide; In dimethyl sulfoxide; at 130℃; for 36.0h;Sealed tube; Inert atmosphere;
General procedure: To a mixture of iodobenzene (1.0 mmol), guanidine nitrate(0.5 mmol), and KOH (3.0 mmol) in DMSO (2 mL), Cu/Cu2O (25 mg)was added. The resulting mixture was then sealed and stirred for 36 h at130 C. After completion of the reaction, the reaction mixture wascooled to room temperature, diluted with water followed by extractionusing ethyl acetate. The organic phase was dried over anhydrousNa2SO4. The crude residue was obtained after evaporation of the solventon rotavapor. The residue was purified by column chromatographywith ethyl acetate and pet-ether as eluent to give the pure product.
With potassium hydroxide; In dimethyl sulfoxide; at 130℃; for 36.0h;Sealed tube; Inert atmosphere;
General procedure: To a mixture of iodobenzene (1.0 mmol), guanidine nitrate(0.5 mmol), and KOH (3.0 mmol) in DMSO (2 mL), Cu/Cu2O (25 mg)was added. The resulting mixture was then sealed and stirred for 36 h at130 C. After completion of the reaction, the reaction mixture wascooled to room temperature, diluted with water followed by extractionusing ethyl acetate. The organic phase was dried over anhydrousNa2SO4. The crude residue was obtained after evaporation of the solventon rotavapor. The residue was purified by column chromatographywith ethyl acetate and pet-ether as eluent to give the pure product.
(S)-N-(N,N'-diphenylcarbamimidoyl)-1-isopropylpyrrolidine-2-carboxamide[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
84%
Stage #1: (S)-1-isopropyl-pyrrolidine-2-carboxylic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide for 5h;
Stage #2: diphenylguanidine In N,N-dimethyl-formamide at 0 - 20℃; for 16h;
Chemistry
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Material Science
For Research Only
120K+ Compounds
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