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CAS No. : | 1023301-73-6 | MDL No. : | MFCD11112288 |
Formula : | C11H22N2O3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | ODOJNXXZXCRBCC-SECBINFHSA-N |
M.W : | 230.30 | Pubchem ID : | 51051649 |
Synonyms : |
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Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
79% | With potassium carbonate; In N,N-dimethyl-formamide; at 90℃; for 4h; | General procedure: A mixture of 2-chloro-5-nitrobenzaldehyde (2 g, 10.8 mmol), 1-isopropylpiperazine (2.07 g, 16.2 mmol) and potassium carbonate (2.68 g, 19.4 mmol) in DMF (10 mL) was heated at 90 C for 4 h. The reaction mixture wascooled to room temperature and diluted with water. The resulting precipitate was collected by filtration, then washed on the filter with water and dried in a vacuum oven to give the title compound (2.8 g, 96%) . LCMS (Method A) : = 0.49 mi m/z = 278 [M+H].Step 1: (R)-tert-butyl 4-(2-formyl-4-nitrophenyl)-2- (methoxymethyl)piperazine-1-carboxylate<strong>[27996-87-8]2-fluoro-5-nitrobenzaldehyde</strong> (1g. 5.91 mmol) was reactedwith (R)-tert-butyl 2-(methoxymethyl)piperazine-1-carboxylate (1g. 4.34 mmol) following the procedure forexample 21 to give the title compound (1.30 g, 79%) |