Home Cart 0 Sign in  

[ CAS No. 1025821-33-3 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1025821-33-3
Chemical Structure| 1025821-33-3
Structure of 1025821-33-3 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 1025821-33-3 ]

Related Doc. of [ 1025821-33-3 ]

Alternatived Products of [ 1025821-33-3 ]
Product Citations

Product Details of [ 1025821-33-3 ]

CAS No. :1025821-33-3 MDL No. :MFCD31689261
Formula : C18H10Cl2N4OS Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 401.27 Pubchem ID :-
Synonyms :
Chemical Name :(Z)-2-((2,6-Dichlorophenyl)amino)-5-(quinoxalin-6-ylmethylene)thiazol-4(5H)-one

Safety of [ 1025821-33-3 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1025821-33-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1025821-33-3 ]

[ 1025821-33-3 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 1025821-33-3 ]
  • [ 6284-40-8 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
With water In acetonitrile at 20 - 50℃; for 4h; 2; 3 EXAMPLE 2 Preparation of: (5Z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5H)-one meglumine monohydrate A suspension of (5Z)-2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one (10.5 mg; 0.0262 mmol.) in acetonitrile (225 uL) was heated to 50° C. and treated with 1M aq. meglumine solution (28.8 uL; 1.1 eq.). The mixture was maintained at 50° C. for approximately two hours then cooled to room temperature and stirred an additional two hours. Filtered and dried in vacuo at 50° C. to give (5Z)-2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one, meglumine salt, approximately 1.0 equivalent of water (7.9 mg). Differential Scanning Calorimetry (DSC) data on Compound D reveals two endothermic events; one at approximately 54° C. and a second event at 158° C. An infrared spectrum is provided in FIG. 1 appended hereto. EXAMPLE 3 Preparation of: (5Z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5H)-one meglumine monohydrate A suspension of (5Z)-2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one (5.07 g; 12.64 mmol.) in acetonitrile (101 mL) was heated to 50° C. Seed crystals (seed crystals can be prepared as described in Example 2) were added, and the mixture was slowly treated with 1M aq. meglumine solution (13.3 mL; 1.05 eq.). The mixture was maintained at 50° C. for approximately two hours then cooled to room temp. and stirred an additional two hours. Filtered and dried in vacuo at 50° C. to give (5Z)-2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one, meglumine salt, approximately 1.0 equivalent of water (6.78 g). Found: % C, 48.72; % H, 4.61; % N, 11.30. C18H10Cl2N4OS.C7H17NO5.H2O requires: % C, 48.86; % H, 4.76; % N, 11.40. Differential Scanning Calorimetry (DSC) data on Compound D reveals three endothermic events; one at approximately 54° C., a second event at approximately 101° C., and a third event at approximately 160° C. An infrared spectrum is provided in FIG. 2 appended hereto.
  • 2
  • [ 936638-01-6 ]
  • [ 130345-50-5 ]
  • [ 1025821-33-3 ]
YieldReaction ConditionsOperation in experiment
88% With piperidine; In ethanol; at 150℃; for 4h;Microwavw irradiation; d) (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one. A suspension of 2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5H)-one (4.95 g; 0.019 mol.), <strong>[130345-50-5]quinoxaline-6-carbaldehyde</strong> (3.00 g; 0.019 mol.) and piperidine (1.88 mL; 0.019 mol.) in ethanol (10.0 mL) was stirred and irradiated at 150 C. for 30 min. in a Biotage Initiator microwave synthesizer. The above procedure was repeated seven further times and the combined, cooled reaction mixtures were poured into water (500 mL) and acidified with 1M aq. HCl (100 mL). The resulting suspension was filtered, washed with water and MeOH, and dried in vacuo to provide (5Z)-2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one (47.0 g, 88%) as a dull brown powder. 1 H NMR (400 MHz, DMSO-d6) delta ppm 13.11 (s, 1H) 8.97 (s, 2H) 8.20 (s,1H) 8.17 (d, J=8.6 Hz, 1H) 8.00 (s,1H) 7.96 (dd, J=8.7, 1.6 Hz, 1H) 7.58 (d, J=8.1 Hz, 2H) 7.25 (t, J=8.1 Hz, 1H). MS(ES+) m/e 401 [M+H]+.
  • 3
  • [ 1025821-33-3 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; water Heating / reflux; 1.e e) (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one, sodium salt, 1.75 H2O. A suspension of (5Z)-2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one (30.7 g; 0.076 mol.) in water (500 mL) was stirred and treated dropwise with 1M aq. NaOH solution (82.0 mL; 1.08 eq.). The mixture was then stirred and heated under reflux whereupon ethanol was added (100 mL) until complete dissolution occurs. The solution was allowed to cool slowly to room temp. (4 h) and filtered to give (5Z)-2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one, sodium salt, 1.75 hydrate (27.1 g) as yellow needles. Mp. 250-255° C. (broad). Found: % C, 47.19; % H, 2.62; % N, 12.05; % Na, 5.06. C18H9Cl2N4OSNa 1.75 H2O requires: % C, 47.52; % H, 2.75; % N, 12.32; % Na, 5.07.
Recommend Products
Same Skeleton Products
Historical Records