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Chemical Structure| 10264-12-7 Chemical Structure| 10264-12-7

Structure of 10264-12-7

Chemical Structure| 10264-12-7

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Product Details of [ 10264-12-7 ]

CAS No. :10264-12-7
Formula : C10H13NO
M.W : 163.22
SMILES Code : CCC(NCC1=CC=CC=C1)=O
English Name :N-benzylpropionamide
MDL No. :MFCD00791238

Safety of [ 10264-12-7 ]

Application In Synthesis of [ 10264-12-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 10264-12-7 ]

[ 10264-12-7 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 5817-70-9 ]
  • [ 97-93-8 ]
  • [ 10264-12-7 ]
YieldReaction ConditionsOperation in experiment
66% In 1,2-dichloro-ethane; toluene at -30 - 65℃; for 72h;
  • 2
  • [ 1380086-06-5 ]
  • [ 100-46-9 ]
  • [ 10264-12-7 ]
  • [ 671-01-2 ]
YieldReaction ConditionsOperation in experiment
1: 62% 2: 60% With dichloro(benzene)ruthenium(II) dimer; N,N-diisopropylimidazolium bromide; sodium hydride In toluene; acetonitrile for 24h; Inert atmosphere; Reflux;
  • 3
  • [ 111-35-3 ]
  • [ 100-46-9 ]
  • [ 588-46-5 ]
  • [ 10264-12-7 ]
YieldReaction ConditionsOperation in experiment
1: 75% 2: 71% With dichloro(benzene)ruthenium(II) dimer; N,N-diisopropylimidazolium bromide; sodium hydride In toluene; acetonitrile at 115℃; for 24h; Inert atmosphere; Reflux;
  • 4
  • [ 106-36-5 ]
  • [ 100-46-9 ]
  • [ 10264-12-7 ]
YieldReaction ConditionsOperation in experiment
82% With carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)-amino]ruthenium(II); potassium <i>tert</i>-butylate In toluene at 120℃; for 48h; Inert atmosphere; Schlenk technique; Reflux; Green chemistry; 2.2. General procedure for synthesis of amides General procedure: A mixture of amine (6.0 mmol), ester (3.0 mmol) and Ru-MACHO (1% mol) in toluene (3.0 mL) was placed in a flask and replaced withnitrogen gas. Then, t-BuOK (20% mol) was added in the mixture in the nitrogen gas flowing. The mixture was heated by reflux under the nitrogen atmosphere. During this time, the nitrogen gas was passed through the Schlenk line allowing the hydrogen gas to evolve from the reaction to escape the reactor. After the 48 h, the solvent was evaporated and the crude product was purified by flash chromatography on silica-gel to give the desired amides in 55-98% yields. The structures of the obtained amide swere determined by FT-IR and 1HNMR.
 

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