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Chemical Structure| 111-35-3 Chemical Structure| 111-35-3

Structure of 111-35-3

Chemical Structure| 111-35-3

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Product Details of [ 111-35-3 ]

CAS No. :111-35-3
Formula : C5H12O2
M.W : 104.15
SMILES Code : OCCCOCC
English Name :3-Ethoxypropan-1-ol
MDL No. :MFCD00002948
InChI Key :XHMWPVBQGARKQM-UHFFFAOYSA-N
Pubchem ID :8109

Safety of [ 111-35-3 ]

Application In Synthesis of [ 111-35-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 111-35-3 ]

[ 111-35-3 ] Synthesis Path-Downstream   1~14

  • 1
  • [ 111-35-3 ]
  • [ 36865-38-0 ]
YieldReaction ConditionsOperation in experiment
With pyridine; phosphorus trichloride at 75℃;
  • 2
  • [ 111-35-3 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
55% With phosphorus tribromide In dichloromethane 1.4 (4) (4) Production of 3-ethoxy-1-bromopropane Phosphorus tribromide (14.5 g) was slowly added dropwise to 16.8 g of 3-ethoxy-1-propanol. Thirty minutes later, the mixture was distilled in vacuo at 150° C. and 90 mmHg. Methylene chloride was added to the distillate, and the mixture was washed with a saturated sodium hydrogen carbonate aqueous solution. After drying, the solvent was removed, and the residue was distilled under reduced pressure to obtain 14.8 g of 3-ethoxy-1-bromopropane (4) having a purity of 94% (yield 55%).
50% With phosphorus tribromide at 0 - 20℃; 27 4.1.27 1-Bromo-3-ethoxypropane (35) At 0°C phosphorus tribromide (4.33g, 16mmol, 1.0equiv) was added dropwise to 3-ethoxypropan-1-ol (4.90g, 47mmol, 2.9equiv). The mixture was stirred overnight at room temperature. After diluting with dichloromethane the mixture was washed with sat. NaHCO3 solution, dried over MgSO4. After filtration and evaporation of the solvent the product was obtained as a colorless oil (3.93g, 23.7mmol, 50%) [39]. 1H NMR (300MHz, CDCl3): δ=1.31 (t, J=7.2Hz, 3H), 2.03 (quint, J=6.2Hz, 2H), 3.39-3.49 (m, 6H).
With pyridine; phosphorus tribromide
With phosphorus tribromide
With pyridine; phosphorus tribromide

  • 4
  • [ 763-69-9 ]
  • [ 111-35-3 ]
YieldReaction ConditionsOperation in experiment
With ethanol; sodium
With methanol; copper chromite at 168 - 172℃; Hydrogenation;
  • 5
  • [ CAS Unavailable ]
  • [ 627-30-5 ]
  • [ 111-35-3 ]
  • [ 3459-83-4 ]
  • 6
  • [ 626-68-6 ]
  • [ CAS Unavailable ]
  • [ 64-17-5 ]
  • [ 111-35-3 ]
  • [ 3459-83-4 ]
  • [ 109-60-4 ]
YieldReaction ConditionsOperation in experiment
With hydrogen at 300℃; var. of catalyst, temp.;
  • 7
  • [ 18509-25-6 ]
  • [ 504-63-2 ]
  • [ 503-30-0 ]
  • [ 111-35-3 ]
YieldReaction ConditionsOperation in experiment
In dichloromethane at 45℃; Yield given. Yields of byproduct given;
1: 3 % Spectr. 2: 97 % Spectr. In dichloromethane Heating;
  • 8
  • [ 111-35-3 ]
  • [ 109-64-8 ]
YieldReaction ConditionsOperation in experiment
91% With sulfuric acid; hydrogen bromide for 10h; Heating;
  • 9
  • [ 111-35-3 ]
  • [ 611-73-4 ]
  • [ 197573-00-5 ]
YieldReaction ConditionsOperation in experiment
89% With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃;
  • 10
  • [ 74-96-4 ]
  • [ 111-35-3 ]
YieldReaction ConditionsOperation in experiment
With xylene at 115 - 120℃;
  • 11
  • [ 111-35-3 ]
  • [ 55357-38-5 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Stage #1: 3-ethoxy-1-propanol With triethylamine; trichlorophosphate In chloroform at 0 - 20℃; Stage #2: choline tosylate With pyridine In chloroform at 20℃; for 48h;
  • 12
  • [ 111-35-3 ]
  • [ 191097-22-0 ]
  • [ 2973839-04-0 ]
YieldReaction ConditionsOperation in experiment
Stage #1: 3-ethoxy-1-propanol; 2-(2-tert-butyldimethylsiloxyethyl)-4H-benzo[1,4]oxazin-3-one With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Stage #2: With methanesulfonic acid In methanol at 20℃;
  • 14
  • [ 249648-16-6 ]
  • [ 111-35-3 ]
  • [ 925902-99-4 ]
YieldReaction ConditionsOperation in experiment
52% Stage #1: 3-ethoxy-1-propanol With sodium hydride In dimethyl sulfoxide at 20℃; for 1h; Stage #2: 5-chloro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-6-(2,4,6-trifluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine-7-amine In dimethyl sulfoxide at 60℃; for 3h;
 

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