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[ CAS No. 1027045-31-3 ]

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Chemical Structure| 1027045-31-3
Chemical Structure| 1027045-31-3
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Product Details of [ 1027045-31-3 ]

CAS No. :1027045-31-3 MDL No. :MFCD10566594
Formula : C8H10BClO2 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :184.43 g/mol Pubchem ID :53216717
Synonyms :

Safety of [ 1027045-31-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1027045-31-3 ]

  • Downstream synthetic route of [ 1027045-31-3 ]

[ 1027045-31-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1027045-31-3 ]
  • [ 49834-22-2 ]
  • N-methyl-3-(4'-chloro-2',6'-dimethylphenyl)benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
200 mg of tetrakistriphenylphosphine palladium was added under cooling with ice to a solution of 0.86 g of <strong>[49834-22-2]N-methyl-3-bromobenzamide</strong> in a mixed solvent of 10 ml of toluene and 3 ml of ethanol, followed by stirring for 20 minutes. 0.93 g of 4-chloro-2,6-dimethylbenzene boronic acid and 4.5 ml of a 2M sodium carbonate aqueous solution were added thereto, and the reaction system was flushed with nitrogen, followed by reflux under heating for 9 hours. After cooling, 50 ml of cold water was added, and then, 50 ml of ethyl acetate was added. The precipitate was filtered off. Then, the organic layer was separated from the filtrate. The water layer was extracted again with 50 ml of ethyl acetate. The organic layers were put together and dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel (Silica gel 60N; spherical and neutral, manufactured by Kanto Kagaku) column chromatography (developing solvent of n- hexane: ethyl acetate=1 : 1) to obtain 0.40 g of the objective compound having a melting point of 137. 1C. Further, NMR of this compound was as follows. 1H-NMR 5 (ppm) 1.98 (s, 6H), 3.02 (d, 3H; J =5. 1 Hz), 6.18 (bs, lH), 7.10 (s, 2H), 7.24 (d, lH ; J =7. 5 Hz), 7.49 (t, lH; J =7. 5 Hz), 7.51 (s, lH), 7.75 (d, lH; J =7. 5 Hz)
  • 2
  • [ 1027045-31-3 ]
  • [ 105-36-2 ]
  • [ 1315482-74-6 ]
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