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[ CAS No. 1036383-28-4 ]

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2D
Chemical Structure| 1036383-28-4
Chemical Structure| 1036383-28-4
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Product Details of [ 1036383-28-4 ]

CAS No. :1036383-28-4MDL No. :MFCD20529509
Formula : C9H10ClFO2 Boiling Point : -
Linear Structure Formula :-InChI Key :-
M.W :204.63Pubchem ID :-
Synonyms :

Computed Properties of [ 1036383-28-4 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

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Application In Synthesis of [ 1036383-28-4 ]

  • Downstream synthetic route of [ 1036383-28-4 ]

[ 1036383-28-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1996-41-4 ]
  • [ 6482-24-2 ]
  • [ 1036383-28-4 ]
YieldReaction ConditionsOperation in experiment
98% With potassium carbonate In acetonitrile at 80℃; for 12h; A A. 2-Chloro-4-fluoro- 1 -(2-methoxyethoxy)benzene. To a solution of 2-chloro-4- fluoro-phenol (5 g, 34.12 mmol) and 1-bromo-2-methoxy-ethane (5.69 g, 40.94 mmol, 3.85 mL) in MeCN (100 mL) was added K2CO3 (9.43 g, 68.24 mmol). The reaction mixture was stirred at 80 °C for 12 hrs. The reaction mixture was cooled and diluted with H2O (50 mL), and then diluted with EtOAc (50 mL × 3). The combined organic layers were washed with brine (50 mL × 2), dried over anhydrousNa2SO4, filtered and concentrated under reduced pressure. Purification (FCC, SiO2, Petroleum ether/Ethyl acetate=1/0 to 20/1) afforded the title compound (6.9 g, 98%) as yellow oil. 1H NMR (400 MHz, CDCl3) δ = 7.14 - 7.12 (m, 1H), 6.93 - 6.91 (m, 2H), 4.15 (t, J= 4.8 Hz, (0306) 2H), 3.78 (t, J= 4.8 Hz, 2H), 3.18 (s, 3H).
34.4% With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h; 16.1 Example 16: Synthesis of 2-chloro-6-fluoro-3-(2-methoxy-ethoxy)-benzaldehyde 123.[0186] 2-Chloro-6-fluoro-3-(2-methoxy-ethoxy)-benzaldehyde 123 was synthesized in 2 steps from 2-chloro-4-fluorophenol 52 as shown in Scheme 38Step 1 - Preparation of2-chloro-4-fluoro-l-(2-methoxy-ethoxy)-benzene (122) [0187] To 2-chloro-4-fluorophenol (52, 2 40 mL, 0 0213 mol) in N.N-dimethylfonnamide (30 0 mL), 1 -bromo-2-methoxy-ethane (2 00 mL, 0 0213 mol) and potassium carbonate (3 00 g, 0 0217 mol) were added under an atmosphere of nitrogen l he reaction was stirred at 80 0C for 2 hours The reaction was poured into water and extracted with ethyl acetate The organic layer was dried over anhydrous sodium sulfate and filtered The filtrate was concentrated and purified by silica gel column chromatography elutmg with 20% ethyl acetate in hexane to give a colorless oil (122, 1 50 g, 34 .
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