Structure of Trospium chloride
CAS No.: 10405-02-4
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Trospium chloride is a competitive antagonist at muscarinic cholinergic receptors, used to treat symptoms of an overactive bladder.
Synonyms: Trospium (chloride); Relaspium
4.5
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
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CAS No. : | 10405-02-4 |
Formula : | C25H30ClNO3 |
M.W : | 427.96 |
SMILES Code : | OC(C1=CC=CC=C1)(C2=CC=CC=C2)C(O[C@@H]3C[C@@]4([H])[N@@+]5(CCCC5)[C@@](CC4)([H])C3)=O.[Cl-] |
Synonyms : |
Trospium (chloride); Relaspium
|
MDL No. : | MFCD00865254 |
InChI Key : | RVCSYOQWLPPAOA-DHWZJIOFSA-M |
Pubchem ID : | 5284631 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Target |
|
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02386072 | - | Completed | - | - | |
NCT00547378 | Urinary Incontinence, Urgency-... More >>frequency Overactive Bladder Less << | Phase 4 | Completed | - | - |
NCT01499069 | Overactive Bladder | Not Applicable | Unknown | December 2015 | Korea, Republic of ... More >> Samsung Medical Center Recruiting Seoul, Korea, Republic of, 135-710 Contact: Kyu-Sung Lee, Ph.D 82-2-3410-3554 ksleedr@skku.edu Contact: Bong-Hee Lim, BA 82-2-3410-3743 bonghee.lim@sbri.co.kr Sub-Investigator: Deok Hyun Han, PhD Sub-Investigator: Young-Suk Lee, PhD Sub-Investigator: Ha Na Lee, PhD Less << |
NCT00547378 | - | Completed | - | - | |
NCT03602508 | - | Active, not recruiting | February 2019 | Australia ... More >> Site AU10000 Sydney, Australia Korea, Republic of Site KR82001 Seoul, Korea, Republic of Less << | |
NCT01166438 | Urge Urinary Incontinence ... More >> Overactive Bladder Less << | Phase 3 | Completed | - | United States, Alabama ... More >> The University of Alabama at Birmingham Birmingham, Alabama, United States, 35249 United States, California USCD Medical Center La Jolla, California, United States, 92037 Kaiser Permanente San Diego, California, United States, 92037 United States, Illinois Loyola University Medical Center Maywood, Illinois, United States, 60153 United States, Michigan Oakwood Hospital Dearborn, Michigan, United States, 48124 Beaumont Hospital Royal Oak, Michigan, United States, 48073 United States, North Carolina Duke University Durham, North Carolina, United States, 27710 United States, Ohio Cleveland Clinic Cleveland, Ohio, United States, 44195 United States, Pennsylvania Magee-Women's Hospital Pittsburgh, Pennsylvania, United States, 15213 United States, Texas University of Texas Southwestern Medical Center Dallas, Texas, United States, 75390 United States, Utah University of Utah Salt Lake City, Utah, United States, 84132 Less << |
NCT00800462 | Spinal Cord Injury ... More >> Neurogenic Detrusor Overactivity Less << | Phase 4 | Completed | - | Canada, Manitoba ... More >> University of Manitoba, Health Sciences Centre Winnipeg, Manitoba, Canada, R3A1R9 Canada, Ontario Toronto Rehabilitation Institute, Lyndhurst Centre Toronto, Ontario, Canada, M4G 3V9 Less << |
NCT01166438 | - | Completed | - | - | |
NCT03697252 | Schizophrenia | Phase 2 | Recruiting | November 5, 2019 | United States, Arkansas ... More >> Woodland International Research Group, LLC Recruiting Little Rock, Arkansas, United States, 72211 United States, California Synergy East Recruiting Lemon Grove, California, United States, 91945 Collaborative Neuroscience Network, LLC. Recruiting Long Beach, California, United States, 90806 NRC Research Institute Recruiting Orange, California, United States, 92868 Artemis Institute for Clinical Research Recruiting San Diego, California, United States, 92103 United States, Georgia Atlanta Center for Medical Research Recruiting Atlanta, Georgia, United States, 30331 United States, Maryland CBH Health, LLC Recruiting Gaithersburg, Maryland, United States, 20877 United States, New Jersey Hassman Research Institute Recruiting Berlin, New Jersey, United States, 08009 United States, Ohio Midwest Clinical Research Center (and IP Shipment) Recruiting Dayton, Ohio, United States, 45417 United States, Texas Community Clinical Research, Inc. Recruiting Austin, Texas, United States, 78754 InSite Clinical Research, LLC Recruiting DeSoto, Texas, United States, 75115 Pillar Clinical Research, LLC Recruiting Richardson, Texas, United States, 75080 Less << |
NCT03109379 | Idiopathic Overactive Bladder ... More >>With Urinary Incontinence Less << | Phase 1 | Active, not recruiting | June 30, 2018 | United States, Michigan ... More >> William Beaumont Hospital - Royal Oak Royal Oak, Michigan, United States, 48073 Michigan Institute of Urology Troy, Michigan, United States, 48084 United States, New York Accumed Research Garden City, New York, United States, 11530-1664 United States, Virginia Urology of Virginia Virginia Beach, Virginia, United States, 23462 Less << |
NCT03572231 | - | Recruiting | December 2019 | Korea, Republic of ... More >> Site KR410008 Recruiting Daejeon, Korea, Republic of Site KR410009 Recruiting Incheon, Korea, Republic of Site KR410001 Recruiting Seoul, Korea, Republic of Site KR410003 Recruiting Seoul, Korea, Republic of Site KR410006 Recruiting Seoul, Korea, Republic of Taiwan Site TW158001 Recruiting Hualien City, Taiwan Less << | |
NCT00465959 | Chronic Obstructive Pulmonary ... More >>Disease Less << | Phase 1 Phase 2 | Completed | - | United States, South Carolina ... More >> United States Investigational Site Spartanburg, South Carolina, United States Less << |
NCT00801684 | Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << | Phase 2 | Completed | - | United States, South Carolina ... More >> Spartanburg Medical Research Spartanburg, South Carolina, United States, 29303 Less << |
NCT03011463 | Pharmacokinetics ... More >> Inhibition Enzyme Drug Interaction Potentiation Less << | Phase 1 | Completed | - | - |
NCT03168828 | Neurogenic Detrusor Overactivi... More >>ty Less << | Phase 1 | Active, not recruiting | September 30, 2018 | United States, Michigan ... More >> Michigan Institute of Urology Troy, Michigan, United States, 48084 United States, North Carolina Carolinas HealthCare System Charlotte, North Carolina, United States, 28207 United States, Virginia Urology of Virginia Virginia Beach, Virginia, United States, 23462 United States, Washington Virginia Mason Seattle, Washington, United States, 98101 Less << |
NCT00801684 | - | Completed | - | - | |
NCT01922115 | Mental Competency ... More >> Urinary Bladder, Overactive Cognitive Function Less << | Phase 4 | Completed | - | United States, North Carolina ... More >> Unc Chapel Hill Urogynecology A2 Clinic Chapel Hill, North Carolina, United States, 27517 Less << |
NCT01178827 | - | Completed | - | - | |
NCT01922115 | - | Completed | - | - | |
NCT01178827 | Overactive Bladder | Phase 4 | Completed | - | United States, Utah ... More >> Salt Lake City, Utah, United States Less << |
NCT01089751 | Overactive Bladder | Phase 4 | Completed | - | United States, California ... More >> La Mesa, California, United States Less << |
NCT03104101 | Overactive Bladder | Not Applicable | Completed | - | - |
NCT00932022 | Obesity Overa... More >>ctive Bladder Incontinence Less << | Phase 4 | Completed | - | United States, California ... More >> La Mesa, California, United States Less << |
NCT00932022 | - | Completed | - | - | |
NCT01089751 | - | Completed | - | - | |
NCT00986401 | Healthy | Phase 1 | Completed | - | United States, Arizona ... More >> Tempe, Arizona, United States Less << |
NCT00863551 | Elderly Pharm... More >>acokinetics Overactive Bladder Less << | Phase 4 | Completed | - | United States, California ... More >> Glendale, California, United States Less << |
NCT00863551 | - | Completed | - | - | |
NCT03709992 | Ureter Stone ... More >>Quality of Life Ureter Obstruction Less << | Not Applicable | Not yet recruiting | November 1, 2019 | - |
NCT02831231 | Schizophrenia | Phase 1 | Completed | - | United States, Ohio ... More >> Medpace Cincinnati, Ohio, United States, 45227 Less << |
NCT00986401 | - | Completed | - | - |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.34mL 0.47mL 0.23mL |
11.68mL 2.34mL 1.17mL |
23.37mL 4.67mL 2.34mL |
|
Dissolving Methods |
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:
in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
|
Tags: Trospium chloride | Trospium (chloride) | Aliphatic Cyclic Hydrocarbons | AChR | Organic Building Blocks | Neuronal Signaling | 10405-02-4
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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