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Chemical Structure| 1085412-37-8 Chemical Structure| 1085412-37-8

Structure of Pyridostatin
CAS No.: 1085412-37-8

Chemical Structure| 1085412-37-8

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Pyridostatin is a G-quadruplex-interacting drug which can promote growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage.

Synonyms: RR82

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Product Details of Pyridostatin

CAS No. :1085412-37-8
Formula : C31H32N8O5
M.W : 596.64
SMILES Code : O=C(C1=CC(OCCN)=CC(C(NC2=NC3=C(C(OCCN)=C2)C=CC=C3)=O)=N1)NC4=CC(OCCN)=C5C=CC=CC5=N4
Synonyms :
RR82
MDL No. :MFCD25976689

Safety of Pyridostatin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Pyridostatin

DNA

Isoform Comparison

Biological Activity

Description
Pyridostatin stabilizes G-quadruplex DNA structures with a dissociation constant (Kd) of 490 nM, leading to growth arrest in human cancer cells by causing DNA damage dependent on both replication and transcription. It specifically targets the Src proto-oncogene, leading to reduced SRC protein levels and decreased SRC-dependent cell movement in human breast cancer cells[1][2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.68mL

0.34mL

0.17mL

8.38mL

1.68mL

0.84mL

16.76mL

3.35mL

1.68mL

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