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[ CAS No. 1092286-30-0 ] {[proInfo.proName]}

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3d Animation Molecule Structure of 1092286-30-0
Chemical Structure| 1092286-30-0
Chemical Structure| 1092286-30-0
Structure of 1092286-30-0 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1092286-30-0 ]

CAS No. :1092286-30-0 MDL No. :MFCD11557228
Formula : C7H6ClNO2 Boiling Point : -
Linear Structure Formula :- InChI Key :DXQDHJSBBMMJOY-UHFFFAOYSA-N
M.W : 171.58 Pubchem ID :33778387
Synonyms :

Calculated chemistry of [ 1092286-30-0 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 11
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.14
Num. rotatable bonds : 1
Num. H-bond acceptors : 3.0
Num. H-bond donors : 1.0
Molar Refractivity : 41.17
TPSA : 50.19 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.35 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.29
Log Po/w (XLOGP3) : 1.41
Log Po/w (WLOGP) : 1.74
Log Po/w (MLOGP) : -0.18
Log Po/w (SILICOS-IT) : 1.82
Consensus Log Po/w : 1.22

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.56

Water Solubility

Log S (ESOL) : -2.13
Solubility : 1.27 mg/ml ; 0.00742 mol/l
Class : Soluble
Log S (Ali) : -2.07
Solubility : 1.47 mg/ml ; 0.00854 mol/l
Class : Soluble
Log S (SILICOS-IT) : -2.4
Solubility : 0.688 mg/ml ; 0.00401 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.49

Safety of [ 1092286-30-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1092286-30-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1092286-30-0 ]

[ 1092286-30-0 ] Synthesis Path-Downstream   1~60

  • 1
  • [ 1092286-30-0 ]
  • [ 1207529-88-1 ]
YieldReaction ConditionsOperation in experiment
With oxalyl dichloride;N,N-dimethyl-formamide; In dichloromethane; at 20℃; for 1.0h; <strong>[1092286-30-0]5-Chloro-2-methyl-nicotinic acid</strong> (4.15 g, 24.2 mmol) is placed in a flask with DCM (100 mL) and oxalyl chloride (3.68 g, 29 mmol). DMF (200 muL) is added and the reaction mixture is stirred at r.t. for 1 hour (gas evolution). The mixture is filtered and the solvent is removed in vacuo to afford the title product which is used in the next step without further purification.
With oxalyl dichloride;N,N-dimethyl-formamide; In dichloromethane; at 20℃; for 1.0h; Step 1 : 5-Chloro-2-methylnicotinoyl chloride<strong>[1092286-30-0]5-Chloro-2-methyl-nicotinic acid</strong> (4.15 g, 24.2 mmol) was placed in a flask with DCM (100 ml) and oxalyl chloride (3.68 g, 29 mmol). DMF (200 muIota) was added and the reaction mixture was stirred at RT for 1 hour (gas evolution). The mixture was filtered and the solvent was removed in vacuo to afford the title product which was used in the next step without further purification.
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20℃; for 1.0h; 5-Chloro-2-methylnicotinoyl chloride<strong>[1092286-30-0]5-Chloro-2-methyl-nicotinic acid</strong> (4.15 g, 24.2 mmol) was placed in a flask with DCM (100 ml) and oxalyl chloride (3.68 g, 29 mmol). DMF (200muIota) was added and the reaction mixture was stirred at RT for 1 hour (gas evolution). The mixture was filtered and the solvent was removed in vacuo to afford the title product which was used without further purification.
  • 2
  • [ 1092286-30-0 ]
  • [ 1207529-77-8 ]
  • 3
  • [ 1092286-30-0 ]
  • [ 1319743-52-6 ]
  • 4
  • [ 1092286-30-0 ]
  • [ 1207529-78-9 ]
  • 5
  • [ 1092286-30-0 ]
  • [ 1319742-70-5 ]
  • 6
  • [ 1092286-30-0 ]
  • [ 1207529-79-0 ]
  • 7
  • [ 1092286-30-0 ]
  • trans-5-chloro-N-[4-(-6-chloro-3-fluoro-3-methyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide [ No CAS ]
  • 8
  • [ 1092286-30-0 ]
  • [ 1319742-74-9 ]
  • 9
  • [ 1092286-30-0 ]
  • [ 1319742-75-0 ]
  • 10
  • [ 1092286-30-0 ]
  • trans-4-[(5-chloro-2-methyl-pyridine-3-carbonyl)-amino]-cyclohexane carboxylic acid methyl ester [ No CAS ]
  • 11
  • [ 1092286-30-0 ]
  • trans-5-chloro-N-(4-hydroxymethyl-cyclohexyl)-2-methyl-nicotinamide [ No CAS ]
  • 12
  • [ 1092286-30-0 ]
  • trans-methanesulfonic acid 4-[(5-chloro-2-methyl-pyridine-3-carbonyl)-amino]-cyclohexylmethyl ester [ No CAS ]
  • 13
  • [ 1092286-30-0 ]
  • trans-5-chloro-N-[4-(3,5-diethyl-pyrazol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide [ No CAS ]
  • 14
  • [ 1092286-30-0 ]
  • trans-4-(5,6-dihydro-4H-cyclopentapyrazol-1-ylmethyl)-cyclohexylamine [ No CAS ]
  • trans-5-chloro-N-[4-(5,6-dihydro-4H-cyclopentapyrazol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide [ No CAS ]
  • trans-5-chloro-N-[4-(5,6-dihydro-4H-cyclopentapyrazol-2-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; for 1.0h; Example 3.1 and 3.2Trans-5-Chloro-N-[4-(5,6-dihydro-4H-cyclopentapyrazol-1 -ylmethyl)- cyclohexyl]-2-methyl-nicotinamide and Trans-5-Chloro-N-[4-(5,6-dihydro-4H- cyclopentapyrazol-2-ylmethyl)-cyclohexyl] -2-methyl-nicotlnamideTrans-4-(5,6-dihydro-4H-cyclopentapyrazof-1-ylrriethyl)-cydohexylamine(intermediate H) (118 mg, 0.461 mmol) was suspended in DMF (2 ml) and treated with 5-chloro-2-methyl-nicotinic acid (96 mg, 0.461 mmol) and HATU (210 mg, 0.554 mmol) . DIPEA (0.321 ml, 1.845 mmol) was added and the reaction mixture was stirred at RT for 1 hour. The mixture was partitioned between DC and water and the organic phase was separated and washed with water, brine, dried (MgS04) and the solvent was removed in vacuo. The crude product was purified by chromatography on basic Alumina, eluting with a iso-hexane/EtOAc to afford a -1: 1 mixture of regiosisomers.LCMS Rt = 2.15 min; [M+H 373. Method LowpH_v002. The mixture was separated using by SFC using conditions described in the 'General Conditions' section.Ex. 3.1 : Trans-5-Chloro-N-[4-(5,6-dihydro-4H-cyclopentapyrazol-1-ylmethyl)- cyclohexyl]-2-methyl-nicotinamide:1 H N R (500MHz, DMSO) delta 8.52 (1 H, d), 8.40 (1 H, d), 7.78 (1 H, d), 7.06 (1H, s), 3.80 (2H,d) 3.66 (1H, m), 2.66 (2H, m), 2.51 (2H, m), 2.47 (3H, s), 1.91 (2H, m), 1.73 (1H, m), 1.59 (2H, m), 1.21 (2H, m), 1.08 (2H, m).Ex. 3.2: Trans-5-Chloro-N-[4-(5,6-dihydro-4H-cyclopentapyrazol-2-ylmethyl)- cyclohexyl] -2-methyl-nicotinamide:1 H NMR {500MHz, DMSO) delta 8.52 (1 H, d), 8.40 (1 H, d), 7.78 (1 H, d), 7.27 (1 H, s), 3.83 (2H,d) 3.65 (1H, m), 2.53 (2H, m), 2.48 (3H, s), 2.30 (2H, m), 1.89 (2H, m), 1.71 (1H, m), 1.58 (2H, m), 1.20 (2H, m), 1.05 (2H, m).
  • 15
  • [ 1092286-30-0 ]
  • 4-(6-(4-amino-4-methylpiperidin-1-yl)pyridin-3-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile dihydrochloride [ No CAS ]
  • 5-chloro-N-(1-(5-(3-cyano-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridin-4-yl)pyridin-2-yl)-4-methylpiperidin-4-yl)-2-methylnicotinamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
42% In dimethyl sulfoxide; at 20℃; for 18.0h; A mixture of 4-(6-(4-amino-4-methylpiperidin-l-yl)pyridin-3-yl)-6-(2-hydroxy-2- methylpropoxy)pyrazolo[l,5-a]pyridine-3-carbonitrile dihydrochloride (Intermediate P48;53 mg, 0.107 mmol), HATU (44.9mg, 0.118 mmol), and 5-Chloro-2-methyl-3- pyridinecarboxylic acid (36.9 mg, 0.107 mmol) in DMSO (1.28 mL, 0.1 M) was treated with DIEA (0.09 mL, 0.54 mmol) and then stirred for 18 h at ambient temperature. The reaction mixture was diluted with EtOAc and washed with water. The organic extracts were washed with brine, then dried over anhydrous Na2S04(S), filtered and concentrated in vacuo. The residue was suspended in 60:40 ACN:water containing 2% TFA. The solution was purified directly by C18 reverse phase chromatography (5-95% ACN in water with 0.1% TFA as the gradient eluent) to afford the title compound as the TFA salt. The TFA salt was treated with saturated NaHCCb(aq) and extracted with DCM. The combined organic extracts were washed with brine, then dried over anhydrous Na2S04(S), filtered and concentrated in vacuo to afford the title compound (26.1 mg, 42% yield). MS (apci) m/z = 574.2 (M+H).
  • 16
  • [ 1092286-30-0 ]
  • 5-(3-(((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylpicolinamide [ No CAS ]
  • 17
  • [ 1092286-30-0 ]
  • 5-(3-(((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)picolinic acid [ No CAS ]
  • 18
  • [ 1092286-30-0 ]
  • 5-chloro-N-((1r,4r)-4-((3-(6-fluoropyridin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-2-methylnicotinamide [ No CAS ]
  • 19
  • [ 1092286-30-0 ]
  • 5-chloro-N-((1r,4r)-4-((3-(5-chloropyrazin-2-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-2-methylnicotinamide [ No CAS ]
  • 20
  • [ 1092286-30-0 ]
  • 5-(3-(((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-2-methylbenzoic acid [ No CAS ]
  • 21
  • [ 1092286-30-0 ]
  • 2-(3-(((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-5-methylbenzoic acid [ No CAS ]
  • 22
  • [ 1092286-30-0 ]
  • C30H31ClN4O4 [ No CAS ]
  • 23
  • [ 1092286-30-0 ]
  • 3-((3-(((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)benzoic acid [ No CAS ]
  • 24
  • [ 1092286-30-0 ]
  • methyl 2-((3-(((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)benzoate [ No CAS ]
  • 25
  • [ 1092286-30-0 ]
  • 5-chloro-N-((1r,4r)-4-((3-(6-fluoro-4-methylpyridin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-2-methylnicotinamide [ No CAS ]
  • 26
  • [ 1092286-30-0 ]
  • 5-chloro-N-((1r,4r)-4-((3-(2-chloropyridin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-2-methylnicotinamide [ No CAS ]
  • 27
  • [ 1092286-30-0 ]
  • 5-chloro-2-methyl-N-((1r,4r)-4-((2-oxo-3-phenyl-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)nicotinamide [ No CAS ]
  • 28
  • [ 1092286-30-0 ]
  • 5-chloro-2-methyl-N-((1r,4r)-4-((3-(3-(methylcarbamoyl)benzyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)nicotinamide [ No CAS ]
  • 29
  • [ 1092286-30-0 ]
  • tert-butyl 3-(((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate [ No CAS ]
  • 30
  • [ 1092286-30-0 ]
  • 5-chloro-2-methyl-N-((1r,4r)-4-((2-oxo-3-(6-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)pyridin-3-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)nicotinamide [ No CAS ]
  • 31
  • [ 1092286-30-0 ]
  • 5-chloro-N-((1r,4r)-4-((3-(6-(2-hydroxyethoxy)pyridin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-2-methylnicotinamide [ No CAS ]
  • 32
  • [ 1092286-30-0 ]
  • 5-(3-(((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)picolinamide [ No CAS ]
  • 33
  • [ 1092286-30-0 ]
  • C32H37ClN6O5 [ No CAS ]
  • 34
  • [ 1092286-30-0 ]
  • 5-chloro-N-((1r,4r)-4-((3-(6-(2-hydroxyethoxy)pyridazin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-2-methylnicotinamide [ No CAS ]
  • 35
  • [ 1092286-30-0 ]
  • 5-chloro-N-((1r,4r)-4-((3-(6-cyclopropylpyridin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-2-methylnicotinamide [ No CAS ]
  • 36
  • [ 1092286-30-0 ]
  • 5-chloro-N-((1r,4r)-4-((3-(6-(2-(hydroxymethyl)morpholino)pyridin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-2-methylnicotinamide [ No CAS ]
  • 37
  • [ 1092286-30-0 ]
  • 5-chloro-N-((1r,4r)-4-((3-(6-(cyclopropylamino)pyridin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-2-methylnicotinamide [ No CAS ]
  • 38
  • [ 1092286-30-0 ]
  • (R)-tert-butyl 3-(((5-(3-(((1r,4R)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)pyridin-2-yl)oxy)methyl)morpholine-4-carboxylate [ No CAS ]
  • 39
  • [ 1092286-30-0 ]
  • (S)-tert-butyl 3-(((5-(3-(((1r,4S)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)pyridin-2-yl)oxy)methyl)morpholine-4-carboxylate [ No CAS ]
  • 40
  • [ 1092286-30-0 ]
  • 5-chloro-N-((1r,4r)-4-((3-(6-((cyclopropylmethyl)amino)pyridin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-2-methylnicotinamide [ No CAS ]
  • 41
  • [ 1092286-30-0 ]
  • 5-chloro-N-(4-((3-(6-(cyclopropylmethoxy)pyridin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-2-methylnicotinamide [ No CAS ]
  • 42
  • [ 1092286-30-0 ]
  • 5-chloro-2-methyl-N-((1r,4r)-4-((2-oxo-3-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)nicotinamide [ No CAS ]
  • 43
  • [ 1092286-30-0 ]
  • 5-chloro-2-methyl-N-((1r,4r)-4-((2-oxo-3-(1H-pyrazolo[3,4-b]pyridin-5-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)nicotinamide [ No CAS ]
  • 44
  • [ 1092286-30-0 ]
  • 5-chloro-N-((1r,4r)-4-((3-(6-(3-hydroxypropoxy)pyridin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-2-methylnicotinamide [ No CAS ]
  • 45
  • [ 1092286-30-0 ]
  • N-((1r,4r)-4-((3-(6-azidopyridin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-5-chloro-2-methylnicotinamide [ No CAS ]
  • 46
  • [ 1092286-30-0 ]
  • N-((1r,4r)-4-((3-(6-aminopyridin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-5-chloro-2-methylnicotinamide [ No CAS ]
  • 47
  • [ 1092286-30-0 ]
  • 5-chloro-N-((1r,4r)-4-((3-(6-fluoro-2-methylpyridin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-2-methylnicotinamide [ No CAS ]
  • 48
  • [ 1092286-30-0 ]
  • 5-chloro-N-((1r,4r)-4-((3-(6-methoxy-2-methylpyridin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-2-methylnicotinamide [ No CAS ]
  • 49
  • [ 1092286-30-0 ]
  • 5-chloro-2-methyl-N-((1r,4r)-4-((3-(2-methyl-6-(methylamino)pyridin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)nicotinamide [ No CAS ]
  • 50
  • [ 1092286-30-0 ]
  • 5-chloro-2-methyl-N-((1r,4r)-4-((2-oxo-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[3,2-b]pyridin-6-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)nicotinamide [ No CAS ]
  • 51
  • [ 1092286-30-0 ]
  • 5-chloro-2-methyl-N-((1r,4r)-4-((2-oxo-3-(1H-pyrrolo[3,2-b]pyridin-6-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)nicotinamide [ No CAS ]
  • 52
  • [ 1092286-30-0 ]
  • 5-chloro-N-((1r,4r)-4-((3-(6-(3-(dimethylamino)azetidin-1-yl)pyridin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-2-methylnicotinamide [ No CAS ]
  • 53
  • [ 1092286-30-0 ]
  • 5-(3-(((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-(1-methyl-1H-pyrazol-3-yl)picolinamide [ No CAS ]
  • 54
  • [ 1092286-30-0 ]
  • 5-chloro-N-((1r,4r)-4-((3-(6-((2-hydroxyethyl)thio)pyridin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-2-methylnicotinamide [ No CAS ]
  • 55
  • [ 1092286-30-0 ]
  • 5-chloro-2-methyl-N-((1r,4r)-4-((3-(6-(((1-methyl-1H-pyrazol-4-yl)methyl)amino)pyridin-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)nicotinamide [ No CAS ]
  • 56
  • [ 1092286-30-0 ]
  • 5-chloro-2-methyl-N-((1r,4r)-4-((2-oxo-3-(6-propionamidopyridin-3-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)nicotinamide [ No CAS ]
  • 57
  • [ 1092286-30-0 ]
  • 5-chloro-2-methyl-N-((1r,4r)-4-((3-(2-(methylamino)pyridin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)nicotinamide [ No CAS ]
  • 58
  • [ 1092286-30-0 ]
  • 5-chloro-N-((1r,4r)-4-((3-(3-cyano-4-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-2-methylnicotinamide [ No CAS ]
  • 59
  • [ 1092286-30-0 ]
  • N-((1r,4r)-4-((3-(3-aminobenzo[d]isoxazol-5-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)cyclohexyl)-5-chloro-2-methylnicotinamide [ No CAS ]
  • 60
  • [ 1092286-30-0 ]
  • (1r,4r)-methyl 4-aminocyclohexanecarboxylate hydrochloride [ No CAS ]
  • [ 1207529-77-8 ]
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Carboxylic Acids

Chemical Structure| 22620-27-5

[ 22620-27-5 ]

5-Chloronicotinic acid

Similarity: 0.87

Chemical Structure| 1000522-43-9

[ 1000522-43-9 ]

2-(5-Chloropyridin-2-yl)acetic acid

Similarity: 0.86

Chemical Structure| 3421-76-9

[ 3421-76-9 ]

2-Ethylnicotinic acid

Similarity: 0.83

Chemical Structure| 886365-46-4

[ 886365-46-4 ]

5-Chloro-3-methylpyridine-2-carboxylic acid

Similarity: 0.77

Chemical Structure| 52833-93-9

[ 52833-93-9 ]

2-Amino-5-chloropyridine-3-carboxylic acid

Similarity: 0.75

Related Parent Nucleus of
[ 1092286-30-0 ]

Pyridines

Chemical Structure| 22620-27-5

[ 22620-27-5 ]

5-Chloronicotinic acid

Similarity: 0.87

Chemical Structure| 1000522-43-9

[ 1000522-43-9 ]

2-(5-Chloropyridin-2-yl)acetic acid

Similarity: 0.86

Chemical Structure| 3421-76-9

[ 3421-76-9 ]

2-Ethylnicotinic acid

Similarity: 0.83

Chemical Structure| 886365-46-4

[ 886365-46-4 ]

5-Chloro-3-methylpyridine-2-carboxylic acid

Similarity: 0.77

Chemical Structure| 1721-26-2

[ 1721-26-2 ]

Ethyl 2-methylnicotinate

Similarity: 0.77