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Chemistry
Heterocyclic Building Blocks
Pyridines
4-Bromo-3-methoxypyridine
Chemistry
Heterocyclic Building Blocks
Organic Building Blocks
Pyridines
Bromides Ethers

[ CAS No. 109911-38-8 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
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Chemical Structure| 109911-38-8
Chemical Structure| 109911-38-8
Structure of 109911-38-8 * Storage: {[proInfo.prStorage]}
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Quality Control of [ 109911-38-8 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification
Alternatived Products of [ 109911-38-8 ]

Product Details of [ 109911-38-8 ]

CAS No. :109911-38-8 MDL No. :MFCD08234926
Formula : C6H6BrNO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 188.02 Pubchem ID :-
Synonyms :

Safety of [ 109911-38-8 ]

Signal Word:Danger Class:6.1
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501 UN#:2810
Hazard Statements:H301-H311-H331 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 109911-38-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 109911-38-8 ]

[ 109911-38-8 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 40473-07-2 ]
  • [ 109911-38-8 ]
  • [ 39858-88-3 ]
  • [ 142929-13-3 ]
  • [ 142929-12-2 ]
YieldReaction ConditionsOperation in experiment
1: 58% 2: 27% 3: 26% With nickel dichloride; zinc In N,N-dimethyl-formamide at 50℃; for 96h;
Reference： [1]Dehmlow, Eckehard V.; Sleegers, Arthur [Liebigs Annalen der Chemie, 1992, # 9, p. 953 - 960]
  • 2
  • [ 19355-04-5 ]
  • [ 109911-38-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 77 percent / CH3COBr 2: 80 percent / Fe, HOAc
With phosphorus tribromide In ethyl acetate at 40℃; for 17h; Reflux; 10.2 Synthesis of 4-bromo-3-methoxypyridine hydrochloride At room temperature, phosphorus tribromide (45 mL, 477 mmol) was added dropwise to a mixture suspension of 3-methoxy-4-nitropyridine 1-oxide (9.54 g, 56.1 mmol) and ethyl acetate (100 mL), at such a rate that the temperature o f the reactionsystem did not exceed 40°C. After the dropwise addition, the resultant mixture was stirred at that temperature for 10 minutes, subsequently heated to the temperature at which the solvent was refluxed, and then stirred at this temperature for 17 hours. The reaction mixture was allowed to cool to room temperature and then poured into ice water (500 mL). This mixture was separated, and the aqueous layer obtained was cooled with ice. Sodium hydroxide was added thereto with cooling with ice at such arate that the temperature of the reaction system did not exceed 20°C, thereby adjusting the pH of the reaction system to 10 or higher. The reaction mixture was extracted withethyl acetate, the organic layer was washed with brine, and anhydrous sodium sulfate was added to dry the layer. After anhydrous sodium sulfate was removed by filtration,the solvent was distilled off under reduced pressure. The residue was purified by flash chromatography to obtain 4-bromo-3-methoxypyridine. The 4-bromo-3-methoxypyridine obtained was dissolved in 100 mL of ethyl acetate, and a 1.0 M hydrogen chloride ether solution (60 mL, 60 mmol) was added to the resultant solution.The solvent was distilled off under reduced pressure to obtain 4-bromo-3-methoxypyridine hydrochloride (7.80 g; yield, 62%).
Reference： [1]Swindell, Charles S.; Duffy, Ruth H. [Heterocycles, 1986, vol. 24, # 12, p. 3373 - 3377]
[2]Current Patent Assignee: ISHIHARA SANGYO KAISHA, LTD. - WO2014/98259, 2014, A1 Location in patent: Page/Page column 40
  • 3
  • [ 109911-38-8 ]
  • [ 192804-36-7 ]
  • [ 1123215-72-4 ]
Reference： [1]Journal of Medicinal Chemistry,2009,vol. 52,p. 1081 - 1099
  • 4
  • [ 769-54-0 ]
  • [ 109911-38-8 ]
Reference： [1]Patent: WO2014/98259,2014,A1

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