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Chemical Structure| 1110767-45-7 Chemical Structure| 1110767-45-7

Structure of Butyzamide
CAS No.: 1110767-45-7

Chemical Structure| 1110767-45-7

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Butyzamide is an orally effective activator of Mpl, which is a thrombopoietin receptor. Butyzamide increases phosphorylation levels of JAK2, STAT3, STAT5 and MAPK, and increases human platelet levels in mouse xenotransplantation experiments.

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Product Details of Butyzamide

CAS No. :1110767-45-7
Formula : C29H32Cl2N2O5S
M.W : 591.55
SMILES Code : O(C)C1=C(C=CC=C1C(OCCC)C(C)(C)C)C=2N=C(NC(=O)C3=CC(Cl)=C(/C=C(/C(O)=O)\C)C(Cl)=C3)SC2
MDL No. :N/A

Safety of Butyzamide

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of Butyzamide

epigenetics
RTK
MAPK
JAK-STAT
TLR

Isoform Comparison

Biological Activity

Description
Butyzamide is an orally bioavailable stimulator of Mpl, a thrombopoietin (TPO) receptor. It enhances the phosphorylation of JAK2, STAT3, STAT5, and MAPK. Additionally, Butyzamide elevates human platelet levels in a mouse xenotransplantation assay[1].

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1.69mL

0.34mL

0.17mL

8.45mL

1.69mL

0.85mL

16.90mL

3.38mL

1.69mL

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