Structure of Hydroxy Itraconazole
CAS No.: 112559-91-8
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Hydroxy itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
Synonyms: Itraconazole metabolite Hydroxy Itraconazole; R-63373; hydroxy-ITZ
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
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CAS No. : | 112559-91-8 |
Formula : | C35H38Cl2N8O5 |
M.W : | 721.63 |
SMILES Code : | O=C1N(C(C)C(O)C)N=CN1C2=CC=C(N3CCN(C4=CC=C(OCC5OC(CN6N=CN=C6)(C7=CC=C(Cl)C=C7Cl)OC5)C=C4)CC3)C=C2 |
Synonyms : |
Itraconazole metabolite Hydroxy Itraconazole; R-63373; hydroxy-ITZ
|
MDL No. : | MFCD28964104 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02633709 | Spinal Muscular Atrophy | Phase 1 | Completed | - | Netherlands ... More >> Pra International Group B.V Groningen, Netherlands, 9728 NZ Less << |
NCT02093728 | Solid Tumours | Phase 1 | Completed | - | United States, Kansas ... More >> Research Site Overland Park, Kansas, United States Less << |
NCT02157883 | Advanced Non Small Cell Lung C... More >>ancer Advanced (Inoperable) Non Small Cell Lung Cancer Less << | Phase 1 | Active, not recruiting | December 31, 2018 | United States, California ... More >> Research Site San Diego, California, United States, 92123 United States, Ohio Research Site Cleveland, Ohio, United States, 44106-4950 Belgium Research Site Edegem, Belgium, 2650 Research Site Gent, Belgium, 9000 Korea, Republic of Research Site Seongnam-si, Korea, Republic of, 13620 Research Site Seoul, Korea, Republic of, 03080 Research Site Seoul, Korea, Republic of, 03722 Research Site Seoul, Korea, Republic of, 06351 Research Site Seoul, Korea, Republic of, 138-736 Netherlands Research Site Amsterdam, Netherlands, 1066 CX Research Site Maastricht, Netherlands, 6229 HX Research Site Rotterdam, Netherlands, 3015 CE Taiwan Research Site Taipei, Taiwan, 10002 Research Site Taipei, Taiwan, 11217 United Kingdom Research Site London, United Kingdom, SE1 9RT Research Site Manchester, United Kingdom, M20 4BX Less << |
NCT02653872 | - | Completed | - | - | |
NCT02370615 | Japanese Healthy Adult Males | Phase 1 | Completed | - | Japan ... More >> Osaka-shi, Osaka, Japan Less << |
NCT03209648 | Healthy Participants | Phase 1 | Completed | - | United Kingdom ... More >> Covance Clinical Research Unit Ltd. Leeds, United Kingdom, LS2 9LH Less << |
NCT01913379 | Healthy Subjects ... More >> Pharmacokinetics Drug-Drug Interaction Less << | Phase 1 | Completed | - | France ... More >> SGS Paris, France, 75015 Less << |
NCT02653872 | Healthy Subjects | Phase 1 | Completed | - | United Kingdom ... More >> Research Site London, United Kingdom Less << |
NCT02259010 | Advanced Solid Tumors ... More >> Relapsed/Refractory Lymphoma Less << | Phase 1 | Unknown | April 2016 | United States, Missouri ... More >> St. Louis, Missouri, United States United States, Oklahoma Oklahoma City, Oklahoma, United States United States, Tennessee Germantown, Tennessee, United States United States, Texas Dallas, Texas, United States Less << |
NCT02370615 | - | Completed | - | - | |
NCT03624959 | Healthy Volunteer | Phase 1 | Recruiting | April 15, 2019 | United States, Texas ... More >> PPD Phase 1 Clinic Recruiting Austin, Texas, United States, 78744 Less << |
NCT02157883 | - | Active, not recruiting | - | - | |
NCT02122692 | Healthy Volunteers | Phase 1 | Completed | - | France ... More >> FR801 Rennes, France, 35042 Less << |
NCT02175407 | Pharmacokinetics ... More >> DDI (Drug-Drug Interaction) Healthy Subjects Less << | Phase 1 | Completed | - | Germany ... More >> PAREXEL International GmbH Berlin, Germany, 14050 Less << |
NCT02328443 | Healthy | Phase 1 | Completed | - | - |
NCT02838264 | Healthy | Phase 1 | Completed | - | Belgium ... More >> Pfizer Clinical Research Unit Brussels, Belgium, B-1070 Less << |
NCT02706535 | Drug Interactions | Phase 1 | Completed | - | United States, Maryland ... More >> GSK Investigational Site Baltimore, Maryland, United States, 21225 Less << |
NCT03579719 | Healthy Volunteers | Phase 1 | Recruiting | November 10, 2018 | Netherlands ... More >> Pra International Group B.V Recruiting Groningen, Netherlands, 9728 NZ Less << |
NCT02975037 | Healthy | Phase 4 | Unknown | April 2017 | - |
NCT02698267 | Neuropathic Pain | Phase 1 | Completed | - | United Kingdom ... More >> Research Site Leeds, United Kingdom, LS2 9LH Less << |
NCT02513446 | Healthy | Phase 1 | Completed | - | Germany ... More >> 1320.20.1 Boehringer Ingelheim Investigational Site Biberach, Germany Less << |
NCT02085967 | Healthy Subjects | Phase 1 | Completed | - | United States, Texas ... More >> PPD Development LLC Austin, Texas, United States, 78744 Less << |
NCT02055703 | Healthy Subjects | Phase 1 | Completed | - | United States, Texas ... More >> WCT Early Development San Antonio, Texas, United States, 78217 Less << |
NCT01787331 | - | Completed | - | - | |
NCT02230033 | Healthy | Phase 1 | Completed | - | United States, Arizona ... More >> Tempe, Arizona, United States Less << |
NCT03222310 | Healthy Volunteers | Phase 1 | Completed | - | United States, Texas ... More >> Covance Research Unit - Dallas Dallas, Texas, United States, 75247 Less << |
NCT02831972 | Healthy | Phase 1 | Completed | - | United States, Arizona ... More >> Tempe, Arizona, United States, 85283 Less << |
NCT01214941 | Pharmacokinetics ... More >> Pharmacodynamics Less << | Phase 4 | Completed | - | Finland ... More >> Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, Turku University and Turku University Hospital Turku, Finland, 20521 Less << |
NCT01929876 | Healthy Participants | Phase 1 | Completed | - | United States, Texas ... More >> Dallas, Texas, United States, 75247 Less << |
NCT01409018 | Pediatric, Cancer | Phase 1 | Completed | - | Korea, Republic of ... More >> Seoul National University Hospital Seoul, Chongno-gu, Korea, Republic of Less << |
NCT03259542 | Drug Interaction Potentiation ... More >> Healthy Less << | Phase 1 | Completed | - | United States, Florida ... More >> SeaView Research Miami, Florida, United States, 33126 Less << |
NCT02130661 | Alzheimer's Disease | Phase 1 | Withdrawn | January 2018 | - |
NCT01787331 | Prostate Adenocarcinoma ... More >> Recurrent Prostate Carcinoma Stage I Prostate Adenocarcinoma AJCC v7 Stage II Prostate Adenocarcinoma AJCC v7 Stage III Prostate Adenocarcinoma AJCC v7 Less << | Phase 2 | Completed | - | United States, California ... More >> University of California, San Francisco San Francisco, California, United States, 94115 Less << |
NCT01929876 | - | Completed | - | - | |
NCT03512548 | Healthy | Phase 1 | Recruiting | December 31, 2018 | United States, Arizona ... More >> Celerion Recruiting Tempe, Arizona, United States, 85283 Less << |
Tags: Hydroxy Itraconazole | Itraconazole metabolite Hydroxy Itraconazole | Antifungal | Others | Drug Metabolite | Anti-Infection | Small Molecule Positive Drugs | Steroids | Biological Buffers | Fluorescence Labeling Reagents | Fluorescent Dyes | Structure | Other Inhibitors/Agonists | 112559-91-8
Precautionary Statements-General | |
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P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
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P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
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P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
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P502 | Refer to manufacturer/supplier for information on recovery/recycling |
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H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
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H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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