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Chemical Structure| 113104-25-9 Chemical Structure| 113104-25-9

Structure of NSC 228155
CAS No.: 113104-25-9

Chemical Structure| 113104-25-9

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NSC228155 can enhance the tyrosine phosphorylation of EGFR via binding to the dimerization domain II. It blocks KIX-KID interaction as well (IC50 = 0.36 μM).

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Product Details of NSC 228155

CAS No. :113104-25-9
Formula : C11H6N4O4S
M.W : 290.25
SMILES Code : [O-][N+]1=CC=CC=C1SC2=CC=C(C3=NON=C32)[N+]([O-])=O
MDL No. :MFCD30742994
InChI Key :ICCFXXDUYSPKOL-UHFFFAOYSA-N
Pubchem ID :313619

Safety of NSC 228155

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of NSC 228155

RTK
JAK-STAT
TLR

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
A549 2 µM Evaluate cytotoxicity, showing low cytotoxicity PMC9254481
SW620 cells 100 µM 12 hours To investigate the activation of PEPT1 transcription by DAC, results showed DAC activated PEPT1 transcription in a dose-dependent manner. PMC11844336
HCT116 cells 100 µM 12 hours To evaluate the effect of terbinafine on CRC cell viability, results showed that terbinafine significantly reduced the viability of HCT116 cells. PMC11844336

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.45mL

0.69mL

0.34mL

17.23mL

3.45mL

1.72mL

34.45mL

6.89mL

3.45mL

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