* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Reference:
[1] Bulletin of the Chemical Society of Japan, 1980, vol. 53, # 1, p. 279 - 280
[2] Tetrahedron Letters, 2007, vol. 48, # 30, p. 5309 - 5311
2
[ 532-32-1 ]
[ 7720-19-6 ]
[ 54-21-7 ]
[ 114-63-6 ]
Reference:
[1] Chemical and Pharmaceutical Bulletin, 1993, vol. 41, # 10, p. 1842 - 1845
3
[ 124-38-9 ]
[ 139-02-6 ]
[ 54-21-7 ]
[ 114-63-6 ]
Reference:
[1] Bulletin of the Chemical Society of Japan, 1980, vol. 53, # 1, p. 279 - 280
[2] Tetrahedron Letters, 2007, vol. 48, # 30, p. 5309 - 5311
4
[ 532-32-1 ]
[ 7720-19-6 ]
[ 54-21-7 ]
[ 114-63-6 ]
Reference:
[1] Chemical and Pharmaceutical Bulletin, 1993, vol. 41, # 10, p. 1842 - 1845
(6R,7R)-7-[2-(2,5-Dichloro-phenylsulfanyl)-acetylamino]-3-(4-hydroxy-benzoyloxymethyl)-5,8-dioxo-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester[ No CAS ]
Referential Example 2 Sodium p-hydroxybenzoate (64 g) and 51 g of benzyl chloride were added to 300 g of xylene, and 1.3 g of tetrabutyl ammonium chloride as a phase transfer catalyst and 2 g of methyl ethyl ketone were added. The mixture was refluxed for 8 hours Benzyl p-hydroxybenzoate was obtained in a yield of 73%, and the ratio of benzyl p-benzyloxybenzoate formed was 13%.
Referential Example 1 Sodium p-hydroxybenzoate (64 g) and 51 g of benzyl chloride were added to 150 g of dimethylformamide, and reacted at 100 C. for 3 hours. Benzyl p-hydroxybenzoate was obtained in a yield of 74%. The ratio of benzyl p-benzyloxybenzoate, a by-product, formed was 10%.
With 4,4?-bis(tributylammoniomethyl)-1,1?-biphenyl dichloride; In water; at 60℃; for 0.5h;Sonication;
The kinetic measurement of the esterification in solid-liquid system was carried out in a thermo-stated batch reactor equipped with ultrasonic generator for each reaction condition. Definite quantities of BTBAMBC (or other PTCs), RBr and diphenyl methane (internal standard) were dissolved in organic solvent and stirred for 15 min in a batch reactor installed in the ultrasonic bath, and reaction temperature was controlled at the desired value. To start the reaction, a definite amount of ArCOONa was introduced into the reactor and the ultrasonic irradiation was activated. At each chosen time, 0.2 cm3 of the organic phase was sampled and diluted in 4 cm3 of methanol for HPLC analysis using C18 column and UV detector at 254 nm with eluent of acetonitrile/methanol/water at 1.0 cm3/min and 37/37/26 (v/v/v).
1 mol of cyclophosphazene and 3 mol of phenol were added to a three-port reactor, and then 100 ml of tetrahydrofuran and 7 mol of anhydrous were added. Sodium carbonate, reacted at 70 C for 8 h; 3 mol of <strong>[114-63-6]sodium p-hydroxybenzoate</strong> was added to the three-reactor, and the reaction was continued for 8 h to obtain product I; product I was poured into a beaker, and hydrochloric acid was added until the pH of the solution was 4, and a white precipitate appeared. After purification by washing with deionized water, it was dried in vacuo to give the product II in a yield of 88%.