Home Cart 0 Sign in  

[ CAS No. 1146290-36-9 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

type HazMat fee
Excepted Quantity Free
Inaccessible (Haz class 6.1), Domestic USD 41.00
Inaccessible (Haz class 6.1), International USD 64.00
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 83.00
Accessible (Haz class 3, 4, 5 or 8), International USD 133.00
Chemical Structure| 1146290-36-9
Chemical Structure| 1146290-36-9
Structure of 1146290-36-9 * Storage: {[proInfo.prStorage]}

Quality Control of [ 1146290-36-9 ]

Related Doc. of [ 1146290-36-9 ]

SDS
Alternatived Products of [ 1146290-36-9 ]
Alternatived Products of [ 1146290-36-9 ]

Product Details of [ 1146290-36-9 ]

CAS No. :1146290-36-9 MDL No. :MFCD11858095
Formula : C6H3ClFNO4S Boiling Point : 338.2±27.0°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :239.61 g/mol Pubchem ID :45791429
Synonyms :

Safety of [ 1146290-36-9 ]

Signal Word:Danger Class:8
Precautionary Statements:P261-P280-P305+P351+P338-P310 UN#:3261
Hazard Statements:H302-H314 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1146290-36-9 ]

  • Upstream synthesis route of [ 1146290-36-9 ]
  • Downstream synthetic route of [ 1146290-36-9 ]

[ 1146290-36-9 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 1242618-52-5 ]
  • [ 1146290-36-9 ]
YieldReaction ConditionsOperation in experiment
76% With 1,3-dichloro-5,5-dimethylhydantoin In water; acetic acid; acetonitrile at 0℃; for 3 h; To a cooled solution of 10 (10.5 g, 40.0 mmol) in CH3CN-HOAc-H2O (400 mL, 5 mL, 10 mL) was added 1,3-dichloro-5,5-dimethylhydantoin (15.8 g, 80.0 mmol) portionwise at 0 °C. After stirring at 0 °C for 3 h, the reaction mixture was concentrated to near dryness in vacuo. The crude product was diluted with CH2Cl2 (500 mL), and the solution was cooled down to ~0 °C. 5percent aqueous NaHCO3 (550 mL) was added slowly at <10 °C, the mixture was stirred at 0 °C for 15 min, The separated organic layer was washed with cooled brine, dried over anhydrous Na2SO4, filtered and concentrated in vacuo. This liquid product was used without further purification. Small amount of the analytical pure sample was obtained by preparative TLC plate (9:1 hexanes/EtOAc) to afford 12 (71percent yield) as a pale yellow solid, mp 44-45 °C (lit15 45-47 °C). 1H NMR (CDCl3) δ 8.32 (dd, J = 9.0, 5.0 Hz, 1H, Ar-H), 7.64 (dd, J = 7.5, 2.5 Hz, 1H, Ar-H), 7.61-7.57 (m, 1H, Ar-H).
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 4, p. 1569 - 1574
[2] Tetrahedron, 2010, vol. 66, # 32, p. 5982 - 5986
[3] Patent: WO2017/156181, 2017, A1, . Location in patent: Paragraph 00363
  • 2
  • [ 369-34-6 ]
  • [ 1146290-36-9 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 4, p. 1569 - 1574
[2] Patent: WO2017/156181, 2017, A1,
Historical Records

Related Functional Groups of
[ 1146290-36-9 ]

Fluorinated Building Blocks

Chemical Structure| 713-21-3

[ 713-21-3 ]

2-Fluoro-5-nitrobenzenesulfonyl chloride

Similarity: 0.98

Chemical Structure| 6668-56-0

[ 6668-56-0 ]

4-Fluoro-3-nitrobenzenesulfonyl Chloride

Similarity: 0.89

Chemical Structure| 2905-21-7

[ 2905-21-7 ]

2-Fluorobenzene-1-sulfonyl chloride

Similarity: 0.70

Chemical Structure| 13918-92-8

[ 13918-92-8 ]

2,4-Difluorobenzene-1-sulfonyl chloride

Similarity: 0.69

Chemical Structure| 26120-86-5

[ 26120-86-5 ]

2,5-Difluorobenzene-1-sulfonyl chloride

Similarity: 0.69

Chlorides

Chemical Structure| 713-21-3

[ 713-21-3 ]

2-Fluoro-5-nitrobenzenesulfonyl chloride

Similarity: 0.98

Chemical Structure| 6668-56-0

[ 6668-56-0 ]

4-Fluoro-3-nitrobenzenesulfonyl Chloride

Similarity: 0.89

Chemical Structure| 121-02-8

[ 121-02-8 ]

2-Methyl-5-nitrobenzene-1-sulfonyl chloride

Similarity: 0.79

Chemical Structure| 4533-95-3

[ 4533-95-3 ]

2-Chloro-5-nitrobenzene-1-sulfonyl chloride

Similarity: 0.72

Chemical Structure| 20201-03-0

[ 20201-03-0 ]

2-Chloro-4-nitrobenzene-1-sulfonyl chloride

Similarity: 0.72

Nitroes

Chemical Structure| 713-21-3

[ 713-21-3 ]

2-Fluoro-5-nitrobenzenesulfonyl chloride

Similarity: 0.98

Chemical Structure| 6668-56-0

[ 6668-56-0 ]

4-Fluoro-3-nitrobenzenesulfonyl Chloride

Similarity: 0.89

Chemical Structure| 121-02-8

[ 121-02-8 ]

2-Methyl-5-nitrobenzene-1-sulfonyl chloride

Similarity: 0.79

Chemical Structure| 4533-95-3

[ 4533-95-3 ]

2-Chloro-5-nitrobenzene-1-sulfonyl chloride

Similarity: 0.72

Chemical Structure| 20201-03-0

[ 20201-03-0 ]

2-Chloro-4-nitrobenzene-1-sulfonyl chloride

Similarity: 0.72

Sulfonyl Chlorides

Chemical Structure| 713-21-3

[ 713-21-3 ]

2-Fluoro-5-nitrobenzenesulfonyl chloride

Similarity: 0.98

Chemical Structure| 6668-56-0

[ 6668-56-0 ]

4-Fluoro-3-nitrobenzenesulfonyl Chloride

Similarity: 0.89

Chemical Structure| 121-02-8

[ 121-02-8 ]

2-Methyl-5-nitrobenzene-1-sulfonyl chloride

Similarity: 0.79

Chemical Structure| 4533-95-3

[ 4533-95-3 ]

2-Chloro-5-nitrobenzene-1-sulfonyl chloride

Similarity: 0.72

Chemical Structure| 20201-03-0

[ 20201-03-0 ]

2-Chloro-4-nitrobenzene-1-sulfonyl chloride

Similarity: 0.72

Aryls

Chemical Structure| 713-21-3

[ 713-21-3 ]

2-Fluoro-5-nitrobenzenesulfonyl chloride

Similarity: 0.98

Chemical Structure| 6668-56-0

[ 6668-56-0 ]

4-Fluoro-3-nitrobenzenesulfonyl Chloride

Similarity: 0.89

Chemical Structure| 121-02-8

[ 121-02-8 ]

2-Methyl-5-nitrobenzene-1-sulfonyl chloride

Similarity: 0.79

Chemical Structure| 4533-95-3

[ 4533-95-3 ]

2-Chloro-5-nitrobenzene-1-sulfonyl chloride

Similarity: 0.72

Chemical Structure| 20201-03-0

[ 20201-03-0 ]

2-Chloro-4-nitrobenzene-1-sulfonyl chloride

Similarity: 0.72