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[ CAS No. 114636-37-2 ]

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Chemical Structure| 114636-37-2
Chemical Structure| 114636-37-2
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Product Details of [ 114636-37-2 ]

CAS No. :114636-37-2 MDL No. :MFCD08704350
Formula : C11H20N2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :228.29 g/mol Pubchem ID :14041208
Synonyms :

Safety of [ 114636-37-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 114636-37-2 ]

  • Upstream synthesis route of [ 114636-37-2 ]
  • Downstream synthetic route of [ 114636-37-2 ]

[ 114636-37-2 ] Synthesis Path-Upstream   1~5

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YieldReaction ConditionsOperation in experiment
60% With triethylamine In dichloromethane at 0 - 20℃; Step 1:A solution of amine 22 (930 mg, 5 mmol) in dry CH2CI2 (50 mL) was cooled to 0 °C, then Et3 (1.4 mL, 10 mmol) and acetic anhydride (567 μ, 6 mmol) were added into the solution, slowly warmed up to rt. After overnight, it was treated with H20 (20 mL) and separated, the aqueous layer was extracted with CH2CI2 twice (10 mL). The combined organic layers was washed with brine (30 mL), then concentrated and purified by silica gel column chromatography to give a desired amide 28 (0.69g, 60percent).1H NMR (CDCI3, 400 MHz): δ 6.36 - 6.06 (br s, 1H), 4.45 - 4.36 (m, 1H), 3.68 - 3.48 (m, 1H), 3.43 - 3.30 (m, 2H), 3.24 - 3.08 (m, 1H), 2.14 - 2.04 (m, 1H), 1.95 (s, 3H), 1.90 - 1.73 (m, 1H), 1.42 (s, 9H).
Reference: [1] Patent: WO2011/160020, 2011, A2, . Location in patent: Page/Page column 68
[2] Patent: WO2006/64336, 2006, A2, . Location in patent: Page/Page column 33
  • 2
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Reference: [1] Patent: WO2011/160020, 2011, A2,
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Reference: [1] Patent: WO2011/160020, 2011, A2,
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Reference: [1] Patent: WO2011/160020, 2011, A2,
  • 5
  • [ 125552-56-9 ]
  • [ 114636-37-2 ]
Reference: [1] Patent: WO2011/160020, 2011, A2,
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