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[ CAS No. 114873-06-2 ]

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Chemical Structure| 114873-06-2
Chemical Structure| 114873-06-2
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Product Details of [ 114873-06-2 ]

CAS No. :114873-06-2 MDL No. :MFCD01862944
Formula : C15H21NO4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :279.33 g/mol Pubchem ID :2761470
Synonyms :

Safety of [ 114873-06-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 114873-06-2 ]

  • Upstream synthesis route of [ 114873-06-2 ]
  • Downstream synthetic route of [ 114873-06-2 ]

[ 114873-06-2 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 24424-99-5 ]
  • [ 114873-06-2 ]
YieldReaction ConditionsOperation in experiment
97% With sodium hydroxide In 1,4-dioxane; water at 0 - 20℃; for 18 h; A solution of L-3-methylphenylalanine (448 mg, 2.5 MMOL) in a mixture of dioxane/water (2: 1,5 ml) and 1M sodium hydroxide (1.5 ml) was stirred and cooled in an ice-water bath. Di-tert-butyl dicarbonate (600 mg, 2.75 MMOL) was added and stirring was continued at room temperature. The reaction was T monitored by tic (ethyl ACETATE/METHANOL/WATER 5: 1: 1). After 18 hours, the solution was CONCENTRATED IN VACUO, acidified with 10percent citric acid solution to pH 2-3 and extracted with ethyl acetate. The extract was washed with brine, dried (MGSO4) and evaporated to give the product as an oil, 680 mg (97percent), HPIC/MS Rt 4.18, M/Z 204 (M-TBUOH-H ).
Reference: [1] Patent: WO2004/20402, 2004, A1, . Location in patent: Page 15
[2] Patent: US6353017, 2002, B1, . Location in patent: Page column 111
  • 2
  • [ 620-13-3 ]
  • [ 114873-06-2 ]
Reference: [1] Journal of Medicinal Chemistry, 2001, vol. 44, # 26, p. 4524 - 4534
  • 3
  • [ 102831-44-7 ]
  • [ 114873-06-2 ]
Reference: [1] Journal of Medicinal Chemistry, 2001, vol. 44, # 26, p. 4524 - 4534
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