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[ CAS No. 1150617-56-3 ]

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Chemical Structure| 1150617-56-3
Chemical Structure| 1150617-56-3
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Product Details of [ 1150617-56-3 ]

CAS No. :1150617-56-3 MDL No. :MFCD12024535
Formula : C7H6BrN3 Boiling Point : 287.0±20.0°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :212.05 g/mol Pubchem ID :40152261
Synonyms :

Safety of [ 1150617-56-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1150617-56-3 ]

  • Upstream synthesis route of [ 1150617-56-3 ]
  • Downstream synthetic route of [ 1150617-56-3 ]

[ 1150617-56-3 ] Synthesis Path-Upstream   1~9

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YieldReaction ConditionsOperation in experiment
35%
Stage #1: With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5 h;
Stage #2: at 20℃; for 0.5 h;
To a solution of 6-bromo-1H-pyrazolo[4,3-b]pyridine (400 mg, 2.02 mmol) in DMF (10 mL) at 0 oC was added 60percent NaH in mineral oil (80.8 mg, 2.02 mmol) and the mixture was stirred at rt for 30 mm. A solution of Mel (287 mg, 2.02 mmol) in DMF (5 mL) was added and the mixture was stirred at rt for 30 mm. Then the mixture was poured into water and extracted with EtOAc. The combined organic layers were washed with brine, dried over Na2504, filtered and concentrated under reduced pressure. The residue was purified by preparative reverse-phase HPLC to give 6-bromo-1-methyl-1H-pyrazolo[4,3-b]pyridine as a white solid (150 mg, 35percent). 1HNMR (300 MHz, DMSO-d6) 8.58-8.60 (m, 2H), 8.30-8.3 1 (m, 1H), 4.06 (s, 3H).
Reference: [1] Patent: WO2015/31613, 2015, A1, . Location in patent: Paragraph 000176
[2] Patent: US2013/281433, 2013, A1, . Location in patent: Paragraph 0854
[3] Patent: WO2016/57834, 2016, A1, . Location in patent: Paragraph 000574
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Reference: [1] Patent: WO2016/198400, 2016, A1, . Location in patent: Page/Page column 100; 101
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Reference: [1] Patent: WO2018/118736, 2018, A1, . Location in patent: Page/Page column 59
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Reference: [1] Patent: WO2016/57834, 2016, A1,
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Reference: [1] Patent: WO2016/57834, 2016, A1,
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Reference: [1] Patent: WO2016/57834, 2016, A1,
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Reference: [1] Patent: WO2016/57834, 2016, A1,
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Reference: [1] Patent: WO2016/57834, 2016, A1,
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Reference: [1] Patent: WO2016/57834, 2016, A1,
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