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[ CAS No. 115063-93-9 ] {[proInfo.proName]}

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Chemical Structure| 115063-93-9
Chemical Structure| 115063-93-9
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Product Details of [ 115063-93-9 ]

CAS No. :115063-93-9 MDL No. :MFCD14706795
Formula : C7H5NOS Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 151.19 Pubchem ID :-
Synonyms :

Safety of [ 115063-93-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 115063-93-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 115063-93-9 ]

[ 115063-93-9 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 115063-93-9 ]
  • [ 74-88-4 ]
  • [ 115063-94-0 ]
YieldReaction ConditionsOperation in experiment
78% In dimethyl sulfoxide; mineral oil 23.E Step E: Step E: Preparation of 6-Methoxythieno[3,2-b]pyridine To a solution of 6-hydroxythieno[3,2-b]pyridine (2.45 g, 16.2 mmol) in dry dimethylsulfoxide (15 ml), under a nitrogen atmosphere, was added 60% sodium hydride in mineral oil (0.75 g, 19 mmol) and let stir at room temperature for 1 hour. Methyl iodide (1.25 ml, 21 mmol) was added to this solution and it was stirred for an additional two hours. The solution was poured into ice/water and extracted with diethyl ether, washed with water, dried over anhydrous sodium sulfate, filtered and carefully evaporated to give an oily product (2.1 g, 78% yield) which was used as is.
  • 2
  • [ 115063-92-8 ]
  • [ 115063-93-9 ]
YieldReaction ConditionsOperation in experiment
With sodium nitrite In sulfuric acid; water 23.D Step D: Step D: Preparation of 6-Hydroxythieno[3,2-b]pyridine To a solution of 6-aminothieno[3,2-b]pyridine (2.5 g, 16.6 mmol) in water (22 ml) containing concentrated sulfuric acid (4.15 ml) and cooled at 0° C. was added dropwise with vigorous stirring a solution of sodium nitrite (1.26 g, 18.3 mmol) in water (7 ml) to give a copious yellow precipitate. This slurry was pipetted dropwise into 5% sulfuric acid (110 ml) maintained at 110° C. After an additional hour, the solution was cooled to room temperature and washed with methylene chloride. This aqueous solution was made basic with sodium hydroxide and washed again with methylene chloride to remove any unreacted starting material. The aqueous solution was then made neutral with hydrochloric acid and the precipitated product was extracted into chloroform/methanol, dried over anhydrous sodium sulfate and filtered through a pad of charcoal and the solvents were evaporated to give product (2.2 g) which was purified by crystallization from hot ethyl acetate/methanol to give pure product (1.81 g, 72% yield), m.p. 228°-230 ° C. Analysis calculated for C7 H5 NOS: N, 9.27; C, 55.61; H, 3.33. Found: N, 9.44; C, 55.54; H, 3.31.
  • 3
  • [ 115063-93-9 ]
  • [ 1581683-62-6 ]
YieldReaction ConditionsOperation in experiment
80% With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; 1x Example lx - Preparation of R Example lx - Preparation of R [0296] To thieno[3,2-b]pyridin-6-ol (500mg, 3.31mmol) in DCM (30mL) was added m-CPBA (1.14g, 4.97mmol) at rt and stirred at rt for overnight. The reaction was washed with sat. NaHC03 and extracted into ethyl acetate. The organic layer was washed with brine, dried and concentrated.The product was purified by silica gel column chromatography, yield: 80%.
  • 4
  • [ 115063-93-9 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
  • 5
  • [ 115063-93-9 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: silver carbonate / chloroform / 60 °C 2: 18F-fluoride anion exchange cartridge / butanone; ethanol 3: butanone; ethanol / 0.33 h / 130 °C
  • 6
  • thieno[3,2-b]pyridin-6-ol [ No CAS ]
  • [ 1228185-09-8 ]
  • C34H40N3OS(1+)*Cl(1-) [ No CAS ]
  • 7
  • thieno[3,2-b]pyridin-6-ol [ No CAS ]
  • [ 1228185-09-8 ]
  • C34H40(18)FN3OS [ No CAS ]
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