Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 1153279-80-1 | MDL No. : | MFCD12173024 |
Formula : | C7H3BrFNO4 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | N/A |
M.W : | 264.01 g/mol | Pubchem ID : | - |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
![]() |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 °C 2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 80 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 °C 2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 80 °C 3: hydrogenchloride / dichloromethane; ethyl acetate / 2 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 °C 2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 80 °C 3: hydrogenchloride / dichloromethane; ethyl acetate / 2 h / 20 °C 4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
76% | With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0℃; for 2h; | 2.a Step a: Synthesis of N-methyl-5-bromo-2-fluoro-3-nitrobenzamide (I-1) tir 5-bromo-2-fluoro-3-nitrobenzoic acid (0.8g, 3.80mmol) at 0°CSolution in dichloromethane (20 mL).Then, HATU (2.0g, 5.25mmol) was added to the reaction,DIPEA (1.88ml, 11.4mmol) andMethylamine hydrochloride (0.31 g, 4.5 mmol).At 0°C, the mixture was stirred for 2 hours, and the mixture became clear.The mixture was extracted three times with dichloromethane, and the combined organic layer was washed with saturated brine solution.Then, the organic phase was dried over anhydrous Na2SO4 and concentrated under vacuum.Finally, the mixture is purified by chromatography,Compound I-1 (0.8 g, yield 76%) was obtained as a yellow solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 6 steps 1: methanol / 2 h / 20 °C / Inert atmosphere 2: N,N,N′,N′-tetramethyl-N″-tert-butylguanidine / acetonitrile / 2 h / 50 °C 3: trifluoroacetic acid; triethylsilane / 5 h / 90 °C 4: acetic acid; ammonium chloride; iron / ethanol / 1 h / 50 - 80 °C 5: pyridine / acetonitrile / 73 h 6: methanesulfonic acid / 16 h / 60 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 9 steps 1: methanol / 2 h / 20 °C / Inert atmosphere 2: N,N,N′,N′-tetramethyl-N″-tert-butylguanidine / acetonitrile / 2 h / 50 °C 3: trifluoroacetic acid; triethylsilane / 5 h / 90 °C 4: acetic acid; ammonium chloride; iron / ethanol / 1 h / 50 - 80 °C 5: pyridine / acetonitrile / 73 h 6: methanesulfonic acid / 16 h / 60 °C 7: bis-triphenylphosphine-palladium(II) chloride; potassium acetate / 1,4-dioxane / 14 h / 25 - 90 °C / Inert atmosphere 8: urea hydrogen peroxide adduct / acetonitrile / 12 h / 25 °C / Inert atmosphere 9: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.33 h / Reflux |
[ 1154278-17-7 ]
Methyl 5-bromo-2-fluoro-3-nitrobenzoate
Similarity: 0.93
[ 1807025-82-6 ]
4-Bromo-2-fluoro-3-nitrobenzoic acid
Similarity: 0.89
[ 1290117-21-3 ]
3-Bromo-4-fluoro-5-nitrobenzoic acid
Similarity: 0.88
[ 1425174-31-7 ]
2,4-Difluoro-3-nitrobenzoic acid
Similarity: 0.87
[ 1154278-17-7 ]
Methyl 5-bromo-2-fluoro-3-nitrobenzoate
Similarity: 0.93
[ 1807025-82-6 ]
4-Bromo-2-fluoro-3-nitrobenzoic acid
Similarity: 0.89
[ 1290117-21-3 ]
3-Bromo-4-fluoro-5-nitrobenzoic acid
Similarity: 0.88
[ 1154278-17-7 ]
Methyl 5-bromo-2-fluoro-3-nitrobenzoate
Similarity: 0.93
[ 1807025-82-6 ]
4-Bromo-2-fluoro-3-nitrobenzoic acid
Similarity: 0.89
[ 1290117-21-3 ]
3-Bromo-4-fluoro-5-nitrobenzoic acid
Similarity: 0.88
[ 1425174-31-7 ]
2,4-Difluoro-3-nitrobenzoic acid
Similarity: 0.87
[ 1807025-82-6 ]
4-Bromo-2-fluoro-3-nitrobenzoic acid
Similarity: 0.89
[ 1290117-21-3 ]
3-Bromo-4-fluoro-5-nitrobenzoic acid
Similarity: 0.88
[ 1154278-17-7 ]
Methyl 5-bromo-2-fluoro-3-nitrobenzoate
Similarity: 0.93
[ 1807025-82-6 ]
4-Bromo-2-fluoro-3-nitrobenzoic acid
Similarity: 0.89
[ 1290117-21-3 ]
3-Bromo-4-fluoro-5-nitrobenzoic acid
Similarity: 0.88