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[ CAS No. 1155-51-7 ]

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Chemical Structure| 1155-51-7
Chemical Structure| 1155-51-7
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Product Details of [ 1155-51-7 ]

CAS No. :1155-51-7 MDL No. :MFCD00045857
Formula : C14H10O4S2 Boiling Point : 525.2°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :306.36 g/mol Pubchem ID :-
Synonyms :

Safety of [ 1155-51-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1155-51-7 ]

  • Downstream synthetic route of [ 1155-51-7 ]

[ 1155-51-7 ] Synthesis Path-Downstream   1~15

  • 1
  • [ 1155-51-7 ]
  • [ 1074-36-8 ]
YieldReaction ConditionsOperation in experiment
38% With acetic acid; zinc for 4h; Heating;
With triphenylphosphine In 1,4-dioxane; water at 30℃;
With sodium carbonate; aluminium
With sodium hydroxide; sodium dithionite
With iron; sodium carbonate
With hydrogenchloride; acetic acid; zinc
With acetic acid; zinc
Multi-step reaction with 2 steps 1: HCl / 1.)reflux, 2 h 2.)r.t., 18 h 2: 42 percent / Zn/AcOH / 4 h / Heating
With hydrogenchloride; zinc In water Inert atmosphere; Cooling with ice;
Multi-step reaction with 2 steps 1: aq. phosphate buffer; dimethyl sulfoxide / 0.5 h 2: GLUTATHIONE / pH 7.4
With acetic acid; zinc

  • 2
  • [ 1155-51-7 ]
  • [ 22855-95-4 ]
YieldReaction ConditionsOperation in experiment
With ammonia; sodium Eintragen von Benzylchlorid in das Reaktionsgemisch;
  • 3
  • [ 1074-36-8 ]
  • [ 1155-51-7 ]
YieldReaction ConditionsOperation in experiment
99.5% Synthesis of B; Compound A (25.0 g. 0.162 mol) was dissolved in methanol ( 100 ml) and triethylamine (23 ml). Then, to the resultant mixture, a 30% hydrogen peroxide aqueous solution (9 ml) was added dropwise, over 10 minutes, under cooling to 50C to 25C under stirring. The reaction liquid was stirred at 250C for additional 30 minutes, and concentrated hydrochloric acid ( 1 5 ml) was added dropwise into the reaction liquid cooled to 50C to 250C under stirring. Then, water (200 ml ) was added thereto, and the whole was stirred at 250C for 1 hour. The thus-precipitated crystals w ere filtered and sufficiently washed with water. The thus-obtained crystals were dried, to thereby obtain EPO <DP n="72"/>white crystals of B (24.7 g. yield 99.5%).
80% The <strong>[1074-36-8]4-mercaptobenzoic acid</strong> (0.53 g; 3.4 mmol) and Iodine (0.44g; 1.7 mmol) were dissolved in 10 ml of ethanol. Triethylamine (1.5ml; 10.2 mmol) was added and the solution was stirred overnight (16h).The excess of iodine was removed with the addiction of a 10% solution of sodium thiosulfate . The cloudy solution was concentrated and combined with HCl 0,01 M till the pH became acid.The pallid yellow precipitate was collected, dried under vacuum and washed with petroleum ether. <n="20"/>This step did not need further purification.YIELD: 80%
41.6% With iodine; In ethanol; at 20℃; After iodine was dissolved to be saturated in 95% ethanol, the solution was slowly added dropwise at room temperature to a solution of <strong>[1074-36-8]4-mercapto benzoic acid</strong> (500 mg, 3.24 mmol) dissolved in ethanol (32 ml). As the reaction proceeded, the reddish brown color of iodine disappeared and crystals were formed, and the iodine was continuously added until the yellow color of the reacted solution no longer disappeared. The generated soli was filtered, and washed with ethanol. The filtered crystals were dried at 50 C. in vacuo to give a gray solid of 4,4'-disulfanediyldibenzoic acid (413 mg, 1.348 mmol, 41.6%). 1H-NMR (DMSO-d6, Varian 400 MHz): delta7.64 (4H, d, J=7.6 Hz), 7.93 (4H, d, J=8.0 Hz), 13.06 (2H, s)
  • 4
  • [ 67-56-1 ]
  • [ 1155-51-7 ]
  • [ 35190-68-2 ]
YieldReaction ConditionsOperation in experiment
95% With hydrogenchloride for 20h; Reflux;
43% With sulfuric acid for 24h; Heating;
With sulfuric acid
With hydrogenchloride 1.)reflux, 2 h 2.)r.t., 18 h; Yield given;
With thionyl chloride; triethylamine 1.) reflux, 2 h, 2.) Et2O, reflux, 2 h; Yield given. Multistep reaction;
1.3 g With sulfuric acid at 65℃; for 18h; Inert atmosphere;
705 mg With sulfuric acid at 65℃; for 18h;

  • 5
  • [ 90-14-2 ]
  • [ 1155-51-7 ]
  • [ 139564-32-2 ]
YieldReaction ConditionsOperation in experiment
71.4% at 260 - 270℃; for 3h;
  • 6
  • [ 10130-89-9 ]
  • [ 4025-64-3 ]
  • [ 1155-51-7 ]
  • [ 1227-49-2 ]
  • 3,4'-Dithiodibenzoesaeure [ No CAS ]
  • 7
  • [ 150-13-0 ]
  • [ 1155-51-7 ]
YieldReaction ConditionsOperation in experiment
40% Stage #1: 4-amino-benzoic acid With hydrogenchloride; sodium hydroxide; sodium nitrite In water Stage #2: With potassium ethyl xanthogenate
15% With sodium sulfide; sodium hydroxide; sulfur In water at 0 - 20℃; for 3h;
With sodium disulfide 1.) diazotation; Multistep reaction;
With sodium sulfide; sodium hydroxide; sulfur; sodium nitrite 1.) -5 deg C, water; 2.) 2 h, water; Yield given. Multistep reaction;
With sodium sulfide; sodium nitrite Yield given. Multistep reaction;

  • 8
  • [ 1155-51-7 ]
  • [ 74-88-4 ]
  • [ 35190-68-2 ]
YieldReaction ConditionsOperation in experiment
89% With sodium hydrogencarbonate In N,N-dimethyl acetamide for 120h;
  • 9
  • [ 1155-51-7 ]
  • [ 75-03-6 ]
  • [ 20057-83-4 ]
YieldReaction ConditionsOperation in experiment
81% With sodium hydrogencarbonate In N,N-dimethyl acetamide for 120h;
With sodium hydrogencarbonate In N,N-dimethyl acetamide at 20℃; for 120h;
  • 10
  • [ 1155-51-7 ]
  • [ 25717-23-1 ]
YieldReaction ConditionsOperation in experiment
91% With pyridine; thionyl chloride In toluene at 70℃; for 4h; 3.1 1) Chlorination reaction: 4,4'-Dithiodibenzoic acid 421g (1.37mol), toluene 1.15L (10.83mol), thionyl chloride 212mL (3mol) and pyridine 33.2mL (0.41mol) were mixed, and acylation was carried out at 70°C React for 4 hours, add 2L n-hexane (15mol), cool to 10°C, crystallize, filter, the filter cake is washed twice with 250mL n-heptane (1.7mol), and dried.429 g of 4,4'-dithiodibenzoyl chloride was obtained with a yield of 91%.
73% With thionyl chloride In toluene Reflux;
With thionyl chloride Heating;
With thionyl chloride for 30h; Heating;
With oxalyl dichloride
In thionyl chloride; toluene 1.A Step A: Step A: 4,4'-Dithiobisbenzoylchloride 4,4'-Dithiobisbenzoic acid (20 g) was refluxed in thionyl chloride (50 ml) for two hours. The reaction mixture was concentrated in vacuo and then coevaporated with toluene to afford the title compound which was used as such in the following step.
With thionyl chloride In toluene
With oxalyl dichloride In N,N-dimethyl-formamide at 0℃; 4.2.1. Synthesis of para- and ortho-substituted aromatic ethylene glycol disulfide polymers57 (general procedure using polymer 20 as an example) 4,4'-Dithiobenzoic acid (11) [23], [58] and [59] (0.213 g, 0.696 mmol) was dissolved in 4 mL of THF, and then DMF (10 μL) was added. The solution was cooled to 0 °C, and oxalyl chloride (13) (0.883 g, 6.96 mmol) was slowly added into the solution via syringe. The solution was stirred for 3 h and then reduced under vacuum to give a yellow oil. The yellow oil was dissolved in 6 mL of CH2Cl2 and then transferred to a flask containing triethylene glycol disulfide (17) (0.981 g, 2.98 mmol), Et3N (0.77 mL, 5.57 mmol), and 46 mL of CH2Cl2 at 0 °C. The reaction mixture was stirred at 0 °C for 30 min and gradually warmed to room temperature, and then stirring continued overnight. The reaction mixture was dissolved in 50 mL of CH2Cl2 and then washed with 50 mL of 0.1 N HCl. The organic layer was then washed with water (2 × 50 mL), dried (MgSO4), filtered, and reduced under vacuum to provide 0.81 g of polymer 20.
With oxalyl dichloride In tetrahydrofuran; N,N-dimethyl-formamide at 0 - 20℃; for 3.5h; 3 3. Preparation of Bis(4-Carboxylchloridophenyl) Disulfide (In Situ) According to the Synthesis Scheme of Formula VIII) Dimethylformamide (0.1 ml of DMF, cat.) was added to a suspension of bis(4-carboxyphenyl) disulfide (1.96 g, 6.4 mmol, 1.0 eq.) in tetrahydrofuran (60 ml of THF). Oxalyl chloride (5.49 ml, 8.12 g, 64.0 mmol, 10.0 eq.) was added dropwise to the reaction mixture at 0° C. and the mixture was stirred at this temperature for 30 min. The resulting yellow solution was then stirred for a further 3 h at RT. The solvent and excess oxalyl chloride were then distilled off. A yellow solid was isolated that was used for the next synthesis step without further analysis or purification (on account of its reactivity).

  • 11
  • [ 1155-51-7 ]
  • [ 593-51-1 ]
  • N-methyl(4-[4-(N-methylcarbamoyl)phenyl]disulfanyl}phenyl)carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
65% Stage #1: 4,4'-Dithiobisbenzoic acid With oxalyl dichloride In tetrahydrofuran; N,N-dimethyl-formamide at 0℃; for 3h; Stage #2: methylamine hydrochloride With triethylamine In dichloromethane at 0 - 20℃; Further stages.;
  • 12
  • [ 1155-51-7 ]
  • [ 506-59-2 ]
  • [ 203246-60-0 ]
YieldReaction ConditionsOperation in experiment
85% Stage #1: 4,4'-Dithiobisbenzoic acid With oxalyl dichloride In tetrahydrofuran; N,N-dimethyl-formamide at 0℃; for 3h; Stage #2: N,N-dimethylammonium chloride With triethylamine In dichloromethane at 0 - 20℃; Further stages.;
  • 13
  • [ 1155-51-7 ]
  • 3-[2-amino-3-(2-cyano-ethoxy)-2-(2-cyano-ethoxymethyl)-propoxy]-propionitrile; hydrochloride [ No CAS ]
  • C16H10N2O2S2((CH2O(CH2)2CN)3)2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
85% Stage #1: 4,4'-Dithiobisbenzoic acid With oxalyl dichloride In tetrahydrofuran; N,N-dimethyl-formamide at 0℃; for 3h; Stage #2: 3-[2-amino-3-(2-cyano-ethoxy)-2-(2-cyano-ethoxymethyl)-propoxy]-propionitrile; hydrochloride With triethylamine In dichloromethane at 0 - 20℃; Further stages.;
  • 14
  • [ 1155-51-7 ]
  • 3-[2-amino-3-(2-ethoxycarbonyl-ethoxy)-2-(2-ethoxycarbonyl-ethoxymethyl)-propoxy]-propionic acid ethyl ester; hydrochloride [ No CAS ]
  • 3-[3-(2-ethoxycarbonyl-ethoxy)-2-(4-{4-[2-(2-ethoxycarbonyl-ethoxy)-1,1-bis-(2-ethoxycarbonyl-ethoxymethyl)-ethylcarbamoyl]-phenyldisulfanyl}-benzoylamino)-2-(2-ethoxycarbonyl-ethoxymethyl)-propoxy]-propionic acid ethyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
89% Stage #1: 4,4'-Dithiobisbenzoic acid With oxalyl dichloride In tetrahydrofuran; N,N-dimethyl-formamide at 0℃; for 3h; Stage #2: 3-[2-amino-3-(2-ethoxycarbonyl-ethoxy)-2-(2-ethoxycarbonyl-ethoxymethyl)-propoxy]-propionic acid ethyl ester; hydrochloride With triethylamine In dichloromethane at 0 - 20℃; Further stages.;
  • 15
  • [ 1155-51-7 ]
  • [ 60984-63-6 ]
  • C102H158N4O70S2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
35% With pyridine; 4 A molecular sieve; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide for 30h;
With pyridine; 4 A molecular sieve; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide cooling;
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