Alternatived Products of [ 1159408-72-6 ]
Product Details of [ 1159408-72-6 ]
CAS No. : | 1159408-72-6 |
MDL No. : | N/A |
Formula : |
C117H175N11O42
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
2407.69
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 1159408-72-6 ]
Signal Word: | |
Class: | N/A |
Precautionary Statements: | |
UN#: | N/A |
Hazard Statements: | |
Packing Group: | N/A |
Application In Synthesis of [ 1159408-72-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1159408-72-6 ]
- 1
-
[ 1159408-65-7 ]
-
[ 1159408-71-5 ]
-
[ 1159408-72-6 ]
Yield | Reaction Conditions | Operation in experiment |
88% |
Stage #1: C38H49NO7*C6H15N With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide
Stage #2: C2HF3O2*C79H128N10O36 In N,N-dimethyl-formamide at 20℃; |
2 Preparation of 117
Compound 116 (1.30 g, 2.06 mmol) and HBTU (0.821 g, 1.05 eq.) were taken together in DMF (30 mL). To that DIEA (1.07 ml, 3 eq) was added and stirred the reaction mixture for 3-4 minutes. A solution of amine 110 (3.00 g, 1.58 mmol) was added followed by 1 eq. DIEA. The reaction mixture stirred overnight at room temperature. Solvents were removed under reduced pressure. The residue dissolved in DCM, washed with bicarbonate and water. DCM layer was dried over sodium sulfate and removed the solvents. The residue was purified by chromatography (eluted first with ethyl acetate, followed by 5-20% MeOH/DCM) to get the product 117 as white solid (3.35 g, 88%). MS: Calculated for C117H175N11O42, 2406.19. Found 2429.10 (M+Na) |