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Structure of 1159598-21-6

Chemical Structure| 1159598-21-6

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Product Details of [ 1159598-21-6 ]

CAS No. :1159598-21-6
Formula : C15H28N2O5
M.W : 316.39
SMILES Code : OC[C@@H]1N(C(OC(C)(C)C)=O)CCN(C(OC(C)(C)C)=O)C1
MDL No. :MFCD28968067
InChI Key :TXCFQKQBPSGAKK-LLVKDONJSA-N
Pubchem ID :66583152

Safety of [ 1159598-21-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H315-H319-H332-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 1159598-21-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1159598-21-6 ]

[ 1159598-21-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 169448-87-7 ]
  • [ 24424-99-5 ]
  • [ 1159598-21-6 ]
YieldReaction ConditionsOperation in experiment
86% With sodium carbonate; In 1,4-dioxane; water; at 0 - 20℃; for 18.0h; Synthesis of (R)-2-Hydroxymethyl-piperazine-l,4-dicarboxylic acid di-tert-butyl ester [A031]. To a stirred solution of (R)-l-Boc-2-Hydroxymethyl-piperazine (1 g, 4.62 mmol) and a2C03 (990 mg, 9.25 mmol) in a mixture of dioxane (8 ml) and water (2 ml) at 0 C was added Di-tert-butyl dicarbonate and the reaction mixture warmed to room temperature. After 18 hours all solvents were removed in vacuo and the resulting residue partitioned between DCM and water. The DCM phase was passed through phase separation cartridge and evaporated to provide a white solid. Purification by column chromatography (0-50% EtOAc:cyclohexane) gave the title compound [A031] as a white solid (1.26g, 86%). 1H- NMR (1H, 300MHz, CDC13): 4.17 (2H, s, br), 3.93 (1H, s, br), 3.84 (1H, d, br), 3.59 (2H, s, br), 2.95 (3H, s, br), 1.46 (18H, s).
 

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