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[ CAS No. 117408-99-8 ] {[proInfo.proName]}

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Chemical Structure| 117408-99-8
Chemical Structure| 117408-99-8
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Product Details of [ 117408-99-8 ]

CAS No. :117408-99-8 MDL No. :MFCD28100924
Formula : C14H12N2O Boiling Point : -
Linear Structure Formula :- InChI Key :FGWZWSGZIWCUFZ-ZDUSSCGKSA-N
M.W : 224.26 Pubchem ID :11241581
Synonyms :

Safety of [ 117408-99-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 117408-99-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 117408-99-8 ]

[ 117408-99-8 ] Synthesis Path-Downstream   1~18

  • 1
  • [ 56613-80-0 ]
  • [ 19547-38-7 ]
  • [ 117408-99-8 ]
YieldReaction ConditionsOperation in experiment
65% With hydrogenchloride at 60℃; for 12h;
  • 2
  • [ 873654-36-5 ]
  • [ 117408-99-8 ]
YieldReaction ConditionsOperation in experiment
With thionyl chloride In chloroform for 4h; Heating;
  • 3
  • [ 29745-44-6 ]
  • [ 117408-99-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: triethylamine / CHCl3 / 20 h / 20 °C 2: thionyl chloride / CHCl3 / 4 h / Heating
Multi-step reaction with 2 steps 1.1: triethylamine / Inert atmosphere 1.2: 2 h / Reflux; Inert atmosphere 2.1: sodium hydride / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
  • 4
  • [ 98-98-6 ]
  • [ 117408-99-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: thionyl chloride / 20 h / Heating 2: triethylamine / CHCl3 / 20 h / 20 °C 3: thionyl chloride / CHCl3 / 4 h / Heating
Multi-step reaction with 3 steps 1.1: thionyl chloride / Reflux; Inert atmosphere 2.1: triethylamine / Inert atmosphere 2.2: 2 h / Reflux; Inert atmosphere 3.1: sodium hydride / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
  • 5
  • sodium hexafluoroantimonate [ No CAS ]
  • RuCl2((CH3)3C6H3)2 [ No CAS ]
  • [ 117408-99-8 ]
  • RuCl(C6H3(CH3)3)(C5H4NC3NOH2)C6H5H(1+)*SbF6(1-)=RuCl(C6H3(CH3)3)(C5H4NC3NOH2)C6H5HSbF6 [ No CAS ]
  • RuCl(C6H3(CH3)3)(C5H4NC3NOH2)C6H5H(1+)*SbF6(1-)=RuCl(C6H3(CH3)3)(C5H4NC3NOH2)C6H5HSbF6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol byproducts: NaCl; soln. of ligand and NaSbF6 in MeOH was added to Ru-complex, heated to reflux for 1 h under N2; evapd., dissolved in CH2Cl2, filtered, recrystd. from CH2Cl2-Et2O; elem. anal.;
  • 6
  • [ 120348-64-3 ]
  • [ 117408-99-8 ]
  • [Rh(I)(2-(4R-phenyl-4,5-dihydrooxazoli-2-yl)-pyridine)(1,5-cyclooctadiene)](1+)[BF4](1-) [ No CAS ]
YieldReaction ConditionsOperation in experiment
95% In tetrahydrofuran under Ar; a ligand (0.34 mmol) was added at 0°C to a soln. of Rh-contg. compd. (0.34 mmol) in dry THF; stirring for 20 h at room temp.; the solvent was removed under vac.; elem. anal.;
  • 7
  • [ 39958-10-6 ]
  • [ 117408-99-8 ]
  • dichloro-2-[(4R)-4-phenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridinepalladium(II) [ No CAS ]
YieldReaction ConditionsOperation in experiment
94% In dichloromethane (N2); Pd complex was added to soln. of ligand in CH2Cl2; mixt. was stirred at room temp. for 2 h; evapd.; triturated with Et2O; washed (Et2O); dried (vac.);
  • 8
  • [ 52462-29-0 ]
  • [ 117408-99-8 ]
  • [RuCl(PyOxPh)(p-cymene)]Cl [ No CAS ]
YieldReaction ConditionsOperation in experiment
92% In methanol under Ar; Ru complex and 2 equiv. of (C5H5N)(C3H3NO)Ph dissolved in degazed MeOH stirred for 6 h at room temp.; solvent evapd., dried under vac.; elem. anal.;
  • 9
  • [ 55449-91-7 ]
  • [ 117408-99-8 ]
  • dichloro-2-[(4R)-4-phenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridineplatinum(II) [ No CAS ]
YieldReaction ConditionsOperation in experiment
94% In 1,2-dichloro-ethane Pt complex was added to soiln. ligand in 1,2-dichloroethane, heated to reflux for 4 h; solvent was removed in vacuo, residue was triturated with Et2O, ppt. wasfiltered; elem. anal.;
  • 11
  • [ 17084-13-8 ]
  • sodium tetrachloroaurate(III) dihyrate [ No CAS ]
  • [ 117408-99-8 ]
  • [Au((R)-4-phenyl-2-(pyridin-2-yl)-4,5-dihydrooxazole)Cl2][PF6]0.5[AuCl4]0.5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
63% In water; acetonitrile aq. soln. of Au complex and solid KPF6 were added to stirred soln. of ligand in MeCN; stirred at room temp. for 48 h in dark; filtered; washed (H2O, EtOH, Et2O); recrystd. (acetone/Et2O); elem. anal.;
YieldReaction ConditionsOperation in experiment
98%
  • 13
  • [ 100-70-9 ]
  • [ 117408-99-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium / ethanol / 24 h / 20 °C 2: chloroform / 16 h / 60 °C
  • 14
  • [ 1452-77-3 ]
  • [ 56613-80-0 ]
  • [ 117408-99-8 ]
YieldReaction ConditionsOperation in experiment
96% In chloroform at 60℃; for 16h; 3 Ph-Pyox (1b) 2.2.3 Ph-Pyox (1b) Prepared similarly from 2-pyridinecarboxyimidate (0.508 g, 3.38 mmol) and d-phenylglycinol (0.464 g, 3.38 mmol). Yield = 0.728 (96%). 1H NMR (400.1 MHz, CDCl3, 293 K) δ = 8.67 (1H, d, 3JHH = 6.0 Hz, pyH), 8.08 (1H, d, 3JHH = 7.9 Hz, pyH), 7.71 (1H, app. t, 3JHH = 7.9 Hz, pyH), 7.36 (1H, m, pyH), 7.30-7.18 (5H, m, PhH), 5.38 (1H, app. t, app. 3JHH = 8.6 Hz, CHPh), 4.81 (1H, app. t, app. JHH = 8.6 Hz, CHHO), 4.30 (1H, app. t, app. JHH = 8.5 Hz, CHHO) ppm. ES-MS: m/z (%) = 225.10 (100) [Ph-Pyox+H]+.
  • 15
  • [ 117408-99-8 ]
  • [ 98-98-6 ]
  • [ 56613-80-0 ]
YieldReaction ConditionsOperation in experiment
With C19H20Cl2CuN4O9; water
  • 16
  • copper(II) perchlorate hexahydrate [ No CAS ]
  • [ 117408-99-8 ]
  • C18H18Cl2CuN4O9 [ No CAS ]
YieldReaction ConditionsOperation in experiment
In acetonitrile for 12h; Inert atmosphere; Synthesis of complexes 2.3.1 General procedure for the preparation of [Cu(R-Pyox)(NCMe)2(ClO4)2] (2) General procedure: To a solution of [Cu(H2O)6][ClO4]2 (74.1mg, 0.200mmol) [warning: perchlorates can be dangerous - this procedure should not be scaled up without appropriate precautions] in acetonitrile (3.0ml) was added a solution of R-Pyox (0.200mmol) in acetonitrile (3.0ml). The resulting blue/green solution was allowed to stir for 12h under argon before removing the volatiles under reduced pressure (Schlenk line vacuum). The solid residue was washed with diethyl ether (2×5ml), extracted into acetonitrile (10ml), filtered through Celite to remove any insoluble residues, and the solvent removed from the filtrate under reduced pressure. The solid product was dried in vacuo for 3h at room temperature to 1.0×10-2mbar to afford the complex as a blue/green powder. Elemental combustion analyses were consistent with the title complexes without the coordinated acetonitrile.
  • 17
  • [ 117408-99-8 ]
  • [ 7646-79-9 ]
  • C28H24CoN4O2(2+)*Cl4Co(2-) [ No CAS ]
YieldReaction ConditionsOperation in experiment
78% In tetrahydrofuran at 20℃; Inert atmosphere; Synthesis and characterization of Cobalt complexes 6a-e and 7a-e General procedure: Complex 6a was obtained by mixing CoCl2 with 2.0 equivalents of ligand in THF and other complexes were prepared by mixing CoCl2 with 1.0 equivalent of ligand in THF. The solution turned green immediately, and a green suspension was obtained after several minutes. The mixture was stirred at room temperature overnight.The precipitate was filtered, washed with dry diethylether, and then dried under vacuum at 40 °C for 24 h.
  • 18
  • C14H13ClN2O [ No CAS ]
  • [ 117408-99-8 ]
YieldReaction ConditionsOperation in experiment
1.12 g With sodium hydride In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; 10 Synthesis of 2-[4'-(R)-phenyloxazolin-2'-yl]pyridine, Ph-Pyox(3e) 2.2.10 Synthesis of 2-[4'-(R)-phenyloxazolin-2'-yl]quinoline, Ph-Quox (5e). This compound was prepared by the same method as for 3b. Yield, 1.34 g (49%). 1H NMR (CDCl3, ppm): 8.28 (m, 3H), 7.88 (d, J = 8.1 Hz, 1H), 7.78 (t, J = 7.5 Hz, 1H), 7.63 (t, J = 7.4 Hz, 1H), 7.44-7.28 (m, 5H), 5.60-5.47 (m, 1H), 5.05-4.93 (m, 1H), 4.48 (d, J = 17.1 Hz, 1H). 13C NMR (CDCl3, ppm): 164.29, 147.78, 146.87, 141.89, 136.92, 130.53, 130.25, 128.99, 128.19, 127.96, 127.71, 127.01, 121.17, 75.73, 70.61. FT-IR (KBr; cm-1): 1645, 1560, 1451, 1365, 1126, 1088, 970, 838, 759, 697, 643. Anal. Calc. for C18H14N2O (274.32): C, 78.81; H, 5.14; N, 10.21. Found: C, 78.60; H, 5.25; N, 10.03%.
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