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[ CAS No. 117832-17-4 ]

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Chemical Structure| 117832-17-4
Chemical Structure| 117832-17-4
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Alternatived Products of [ 117832-17-4 ]
Alternatived Products of [ 117832-17-4 ]

Product Details of [ 117832-17-4 ]

CAS No. :117832-17-4 MDL No. :MFCD07779006
Formula : C8H10IN Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :247.08 g/mol Pubchem ID :14040291
Synonyms :

Safety of [ 117832-17-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 117832-17-4 ]

  • Downstream synthetic route of [ 117832-17-4 ]

[ 117832-17-4 ] Synthesis Path-Downstream   1~15

  • 1
  • [ 95-64-7 ]
  • [ 117832-17-4 ]
YieldReaction ConditionsOperation in experiment
93% With 1-butyl-3-methyl-pyridinium dichloroiodate; at 80℃; for 1h;Inert atmosphere; 3,4-Dimethylaniline (0.1 g, 0.82mmol) and l-butyl-3-methylpyridinium dichloroiodate (BMPDCI) (0.344 g, 0.99 mmol) were added in 10 ml one necked round bottomed flask in an inert atmosphere. The reaction mixture was heated at 80 C for lhr. The reaction was monitored by TLC. After the reaction was completed (TLC), ethyl acetate (10ml) was added followed by addition of water (10ml). The entire reaction mixture was extracted with ethyl acetate (3x10ml). The combined ethyl acetate layer was washed with water, brine and dried over anhydrous sodium sulphate. The separated combined organic layers, was evaporated under vacuum, to afford the crude product. This crude product was purified by silica gel column chromatography to afford pure 2-iodo-4,5-dimethylaniline in 0.19 g, (93% yield). 1H NMR (CDCI3 delta/ppm): 7.31 (s, 1H), 6.49 (s, 1H), 3.79 (broad singlet, 2H, NH2), 2.12-2.14 (d, 6H, Ar-CH3).
85% With iodine; sodium hydrogencarbonate; In methanol; water; at 20℃; for 1h;Inert atmosphere; [Example 496] Compound dd47 2-Iodo-4,5-dimethylaniline [1071] Iodine (2.06 g, 8.11 mmol) was added in 10 parts to a mixed solution of 3,4-dimethylaniline (893 mg, 7.37 mmol) and sodium bicarbonate (683 mg, 8.14 mmol) in MeOH/ water (7 ml/7 ml), and it was stirred at room temperature for one hour under a nitrogen atmosphere. Followed by addition of water to the reaction mixture and extraction with dichloromethane, the organic layer was then washed with a saturated aqueous solution of sodium thiosulfate and dried over anhydrous magnesium sulfate. The drying agent was removed by filtration, followed by concentration under reduced pressure. The resultant residue was purified by silica gel column chromatography (ethyl acetate/hexane) to yield the title compound (1.54 g, 85%) as a brown solid. LCMS: m/z 248 [M+H]+ HPLC retention time: 1.91 min (analysis condition D)
85% With iodine; sodium hydrogencarbonate; In methanol; water; at 20 - 25℃; for 1h;Inert atmosphere; Iodine (2.06 g, 8.11 mmol) was added in 10 parts to a mixed solution of 3,4-dimethylaniline (893 mg, 7.37 mmol) and sodium bicarbonate (683 mg, 8.14 mmol) in MeOH/water (7 ml/7 ml), and it was stirred at room temperature for one hour under nitrogen atmosphere. Followed by addition of water to the reaction mixture and extraction with dichloromethane, the organic layer was then washed with a saturated aqueous solution of sodium thiosulfate and dried over anhydrous magnesium sulfate. The drying agent was removed by filtration, followed by concentration under reduced pressure. The resultant residue was purified by silica gel column chromatography (ethyl acetate/n-hexane) to yield the title compound (1.54 g, 85%) as a brown solid. LCMS: m/z 248 [M+H]+ HPLC retention time: 1.91 min (analysis condition C)
  • 4
  • [ 598-25-4 ]
  • [ 201230-82-2 ]
  • [ 117832-17-4 ]
  • 2,2,6,7-tetramethyl-3-methylene-2,3-dihydro-1H-quinolin-4-one [ No CAS ]
  • 5
  • [ 5664-20-0 ]
  • [ 201230-82-2 ]
  • [ 117832-17-4 ]
  • C15H17NOCH2CH2 [ No CAS ]
  • 7
  • [ 117832-17-4 ]
  • 2-(4,6,7-trimethyl-2-quinolinyl)-4,5-dimethylphenylamine [ No CAS ]
  • 10
  • [ 551-93-9 ]
  • [ 117832-17-4 ]
  • [ 1018958-39-8 ]
  • [ 1018958-54-7 ]
  • 11
  • [ 17852-28-7 ]
  • [ 117832-17-4 ]
  • [ 1018958-44-5 ]
  • 12
  • [ 719-59-5 ]
  • [ 117832-17-4 ]
  • [ 1018958-47-8 ]
  • 13
  • [ 629-05-0 ]
  • [ 117832-17-4 ]
  • 4,5-dimethyl-2-oct-1-yn-1-ylaniline [ No CAS ]
  • 15
  • [ 99685-96-8 ]
  • [ 117832-17-4 ]
  • [ 1157951-25-1 ]
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