Home Cart 0 Sign in  

[ CAS No. 1186048-28-1 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1186048-28-1
Chemical Structure| 1186048-28-1
Structure of 1186048-28-1 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 1186048-28-1 ]

Related Doc. of [ 1186048-28-1 ]

Alternatived Products of [ 1186048-28-1 ]

Product Details of [ 1186048-28-1 ]

CAS No. :1186048-28-1 MDL No. :MFCD18320269
Formula : C15H12O4 Boiling Point : -
Linear Structure Formula :- InChI Key :LIAIHMJPPFPMBK-UHFFFAOYSA-N
M.W : 256.25 Pubchem ID :21312578
Synonyms :

Safety of [ 1186048-28-1 ]

Signal Word:Warning Class:
Precautionary Statements:P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1186048-28-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1186048-28-1 ]

[ 1186048-28-1 ] Synthesis Path-Downstream   1~23

  • 1
  • [ 67-56-1 ]
  • [ 1186048-28-1 ]
  • dimethyl 2-methyl-[1,1′-biphenyl]-4,4′-dicarboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
95% With sulfuric acid at 80℃; for 12h; Reflux; 1.1 (A), methyl biphenyl dicarboxylic acid dimethyl ester (A1) synthesis: weighing 20 mmol methyl biphenyl dicarboxylic acid add to 150 ml of methanol in the reaction container, slowly dropping 1.5 ml of concentrated sulfuric acid, after and milling, heating to 80 °C reflux reaction 12 h, cooling to room temperature, the occurrence of steaming and to a large quantity of solid precipitate, filtering, and is used for freezing methanol washing, drying, to obtain white solid is the methyl biphenyl dicarboxylic acid dimethyl ester (A1), yield 95%.
2.42 g With sulfuric acid Reflux;
5.35 g With sulfuric acid for 12h; Reflux;
  • 2
  • [ 1186048-28-1 ]
  • [ 1186048-29-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sulfuric acid / Reflux 2: N-Bromosuccinimide; 1,1'-azobis(1-cyanocyclohexanenitrile) / benzene / Reflux
Multi-step reaction with 2 steps 1: sulfuric acid / 12 h / Reflux 2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / benzene / 12 h / 80 °C
  • 3
  • [ 1186048-28-1 ]
  • [ 1186048-30-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: sulfuric acid / Reflux 2: N-Bromosuccinimide; 1,1'-azobis(1-cyanocyclohexanenitrile) / benzene / Reflux 3: tetrahydrofuran
  • 4
  • [ 1186048-28-1 ]
  • [ 1186048-23-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: sulfuric acid / Reflux 2: N-Bromosuccinimide; 1,1'-azobis(1-cyanocyclohexanenitrile) / benzene / Reflux 3: tetrahydrofuran 4: sodium hydroxide / tetrahydrofuran; methanol
  • 5
  • [ 7697-28-1 ]
  • [ 14047-29-1 ]
  • [ 1186048-28-1 ]
YieldReaction ConditionsOperation in experiment
91% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; triphenylphosphine; In water; N,N-dimethyl-formamide; at 90℃; for 24h; 4-Bromo-3-methylbenzoic acid (0.389 g, 1.81 mmol), 4-carboxybenzeneboronic acid (0.300 g, 1.81 mmol), PPh3 (0.047 g, 0.18 mmol), Pd(PPh3)4 (0.105 g, 0.095 mmol) and 2M K2CO3 aqueous solution (3 ml) were dissolved in DMF (10 ml). The mixture was stirred at 90 for 1 day. The mixture was then cooled to room temperature and diluted with water. The solution was washed with ethyl acetate and 2 N HCl aqueous solution was added to give white precipitates. The precipitates were filtered, wash with water and dried under vacuum. The product was white solid (0.418 g, 91%).
  • 6
  • [ 553-26-4 ]
  • manganese(II) chloride tetrahydrate [ No CAS ]
  • [ 1186048-28-1 ]
  • [ 1431970-42-1 ]
YieldReaction ConditionsOperation in experiment
60% Stage #1: 4,4'-bipyridine; manganese(II) chloride tetrahydrate; 2-methyl-[1,1′-biphenyl]-4,4′-dicarboxylic acid In ethanol; water at 20℃; for 0.166667h; Stage #2: With sodium hydroxide In ethanol; water at 70℃; for 120h; Sealed tube; 2 Synthesis Prismatic yellow crystals of 2 were obtained by a similar procedure except that phen was replaced by ,4′-bipy (0.050 mmol, 0.008 g). However, the bulk product was contaminated by uncharacterized powdery substance, which was difficult to remove. A few crystals were sorted out manually for IR and single-crystal X-ray analyses. The pure crystals of 2 have been obtained by a different method. A mixture of MnCl2·4H2O (0.050 mmol, 0.010 g), H2mbpdc (0.050 mmol, 0.013 g) and 4,4′-bipy (0.050 mmol, 0.008 g) in aqueous ethanol (50%, 6 mL) was stirred for 10 min at room temperature, the pH value of which had been adjusted to approximately 7 with a 0.1 mol L-1 NaOH solution. The mixture was sealed in a 23 mL Teflon-lined autoclave and heated at 70 °C for 5 days. After cooling to room temperature slowly, prismatic yellow crystals of 2 were obtained in yield 60%. The phase purity has been confirmed by powder X-ray analysis. Single crystal X-ray analysis and IR spectra suggested that the crystals obtained by the two methods are the same. Elemental analysis calcd. for C25H18N2O4Mn (M = 465.36) (%): C, 64.52; H, 3.90; N, 6.02. Found (%): C, 64.17; H, 4.04; N, 5.47. IR (KBr, νmax/cm-1): 1583(vs), 1537(s), 1394(vs), 1217(m), 1003(w), 811(m), 780(m), 727(w).
  • 7
  • [ 66-71-7 ]
  • manganese(II) chloride tetrahydrate [ No CAS ]
  • [ 1186048-28-1 ]
  • [ 1431970-41-0 ]
YieldReaction ConditionsOperation in experiment
55% Stage #1: 2-methyl-[1,1′-biphenyl]-4,4′-dicarboxylic acid With sodium hydroxide In water Stage #2: 1,10-Phenanthroline; manganese(II) chloride tetrahydrate In ethanol; water at 20℃; Sealed tube; 2 Synthesis The compound was synthesized by a liquid phase diffusion method. An aqueous solution of NaOH (0.1 mol L-1) was added dropwise o a stirred suspension of 2mbpdc (0.050 mmol, 0.013 g) in 3 mL ater until the mixture was almost clear (pH ≈ 7). After iltration, the solution was transferred into a 25 mL clean tube, and then aqueous ethanol (80%, mL) and an ethanol solution (3 mL) containing MnCl2·4H2O 0.050 mmol, 0.010 g) and phen (0.050 mmol, 0.009 g) were successively added dropwise to give hree-layer system. The tube was sealed and left undisturbed at room emperature. Slow diffusion yielded prismatic yellow crystals of 1 after about 2 weeks in yield 55%. Elemental analysis calcd. or C27H18N2O4Mn (M = 489.38) (%): C, 66.27; H, 3.71; N, 5.72. Found %): C, 65.86; H, 3.69; N, 5.64. IR (KBr, νmax/cm-1): 1644(vs), 1597(vs), 1549(s), 1387(vs), 096(w), 1005(w), 847(m), 789(m), 724(m).
  • 8
  • manganese(II) chloride tetrahydrate [ No CAS ]
  • [ 64-17-5 ]
  • [ 1186048-28-1 ]
  • [ 1135-32-6 ]
  • [Mn(2-methyl-4,4'-biphenyldicarboxylate)(1,2-di(4-pyridyl)ethene)]*C2H5OH [ No CAS ]
YieldReaction ConditionsOperation in experiment
Stage #1: 2-methyl-[1,1′-biphenyl]-4,4′-dicarboxylic acid With sodium hydroxide In water Stage #2: manganese(II) chloride tetrahydrate; ethanol; trans-1,2-bis(4-pyridyl)ethylene In water at 20℃; Sealed tube; 2 Synthesis General procedure: The compound was synthesized by a liquid phase diffusion method. An aqueous solution of NaOH (0.1 mol L-1) was added dropwise o a stirred suspension of 2mbpdc (0.050 mmol, 0.013 g) in 3 mL ater until the mixture was almost clear (pH ≈ 7). After iltration, the solution was transferred into a 25 mL clean tube, and then aqueous ethanol (80%, mL) and an ethanol solution (3 mL) containing MnCl2·4H2O 0.050 mmol, 0.010 g) and phen (0.050 mmol, 0.009 g) were successively added dropwise to give hree-layer system. The tube was sealed and left undisturbed at room emperature. Slow diffusion yielded prismatic yellow crystals of 1 after about 2 weeks in yield 55%.
  • 9
  • zinc nitrate tetrahydrate [ No CAS ]
  • [ 1240557-01-0 ]
  • [ 1186048-28-1 ]
  • [Zn4O(NH2-(1,1'-biphenyl)-4,4'-dicarboxylic acid)1.2(Me-(1,1'-biphenyl)-4,4'-dicarboxylic acid)1.8] [ No CAS ]
YieldReaction ConditionsOperation in experiment
In N,N-dimethyl-formamide at 85℃; for 72h;
  • 10
  • [ 148547-19-7 ]
  • [ 99768-12-4 ]
  • [ 1186048-28-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 90 °C / Inert atmosphere 2: sodium hydroxide / water
  • 11
  • dimethyl 2-methyl-[1,1′-biphenyl]-4,4′-dicarboxylate [ No CAS ]
  • [ 1186048-28-1 ]
YieldReaction ConditionsOperation in experiment
81.1% With potassium hydroxide In tetrahydrofuran; methanol; water
Stage #1: dimethyl 2-methyl-[1,1′-biphenyl]-4,4′-dicarboxylate With sodium hydroxide In water Stage #2: With hydrogenchloride In water
  • 12
  • [ 1186048-28-1 ]
  • C23H23N2O4(1+)*Br(1-) [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: sulfuric acid / 12 h / Reflux 2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / benzene / 12 h / 80 °C 3: acetonitrile / 2 h / 80 °C
  • 13
  • [ 1186048-28-1 ]
  • C21H19N2O4(1+)*Br(1-) [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: sulfuric acid / 12 h / Reflux 2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / benzene / 12 h / 80 °C 3: acetonitrile / 2 h / 80 °C 4: lithium hydroxide; hydrogen bromide / water; methanol / 12 h / 20 °C
  • 14
  • [ 1186048-28-1 ]
  • 2-methyl-1,1'-biphenyl-4,4'-dimethanol [ No CAS ]
YieldReaction ConditionsOperation in experiment
16% With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 60℃; for 24h; 2-Methyl-1,1'-biphenyl-4,4'-dimethanol. To a solution of LAH (0.373 g, 9.82 mmol) in THF (10 ml), 2-Methyl-1,1'-biphenyl-4,4'-dicarboxylic acid (0.839 g, 3.27 mmol) in THF (5 ml) was added at 0 . The mixture was stirred at 60 for 1 day. The mixture was then cooled to 0 , quenched by addition of water and NaOH aq. and filtered. The filtrate was dried over Na2SO4 and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (ethyl acetate : hexane = 1:3 →1:1) to give 2-methyl-1,1'-biphenyl-4,4'-dimethanol as colorless liquid (0.215 g, 16 %).
  • 15
  • [ 1186048-28-1 ]
  • 4,4'-bis(bromomethyl)-2-methyl-1,1'-biphenyl [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 0 - 60 °C 2: phosphorus tribromide / tetrahydrofuran / 3 h / 0 - 20 °C
  • 16
  • [ 1186048-28-1 ]
  • 4,4’-bis[(diethoxyphosphinyl)methyl]-2-methyl-1,1’-biphenyl [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 0 - 60 °C 2: phosphorus tribromide / tetrahydrofuran / 3 h / 0 - 20 °C 3: 12 h / 150 °C
  • 17
  • [ 1186048-28-1 ]
  • C29H24 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 0 - 60 °C 2.1: phosphorus tribromide / tetrahydrofuran / 3 h / 0 - 20 °C 3.1: 12 h / 150 °C 4.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C 4.2: 2 h / 20 °C
  • 18
  • [ 4479-73-6 ]
  • zinc(II) nitrate hexahydrate [ No CAS ]
  • [ 1186048-28-1 ]
  • [ 1310-73-2 ]
  • [Zn<SUB>9</SUB>(2-methyl-4,4′-biphenyldicarboxylate)<SUB>7</SUB>(3,3'-dimethyl-4,4'-bipyridiney)<SUB>2</SUB>(μ<SUB>3</SUB>-OH)<SUB>4</SUB>]·(H<SUB>2</SUB>O)<SUB>5</SUB>}<SUB>n</SUB> [ No CAS ]
YieldReaction ConditionsOperation in experiment
58% Stage #1: 2-methyl-[1,1′-biphenyl]-4,4′-dicarboxylic acid; sodium hydroxide In water Heating; Stage #2: 3,3'-dimethyl-4,4'-bipyridyl; zinc(II) nitrate hexahydrate In water at 130℃; for 72h; Autoclave; High pressure; 2.2 Synthesis of [Zn9(mbpdc)7(3,3′-dmbpy)23-OH)4]·(H2O)5}n (1) The pH of H2mbpdc (0.128g, 0.5mmol) hot aqueous solution (10mL) was adjusted to 7-8 with NaOH. Then Zn(NO3)2·6H2O (0.148g, 0.5mmol) and 3,3′-dmbpy (0.046g, 0.25mmol) were added in above aqueous solution. The resulting mixture were sealed in a 23mL Teflon-lined stainless steel autoclave and heated at 130C for 3days under autogenous pressure. Colorless crystals were obtained in a yield of 58% based on mbpdc. Anal. Calcd for Zn9C129H108N4O37 (1): C, 53.5; N, 1.9; H, 3.7. Found: C, 54.4; N, 1.3; H, 3.0. IR (KBr pellet) (cm-1): 3415(s, (O-H)), 3046(w, (Cmethyl-H)), 2989(w, (Cmethyl-H)), 1609(w, asymmetric (C-O-C)), 1585(m), 1502(s), 1375(vs symmetric (C-O-C)), 1197(w), 1173(w), 1133(w), 1102(w), 1002(m), 848(m), 777(s), 721(m), 670(m), 456(w) (Fig. S1).
  • 19
  • lead(II) nitrate [ No CAS ]
  • [ 1186048-28-1 ]
  • [ 1310-73-2 ]
  • [Pb<SUB>11</SUB>(2-methyl-4,4'-biphenyldicarboxylate)<SUB>7</SUB>(μ<SUB>4</SUB>-O)<SUB>3</SUB>(μ<SUB>3</SUB>-OH)<SUB>2</SUB>]·(H<SUB>2</SUB>O)}<SUB>n</SUB> [ No CAS ]
YieldReaction ConditionsOperation in experiment
55% Stage #1: 2-methyl-[1,1′-biphenyl]-4,4′-dicarboxylic acid; sodium hydroxide In water Heating; Stage #2: lead(II) nitrate With 3,3'-dimethyl-4,4'-bipyridyl In water at 130℃; for 72h; Autoclave; High pressure; 2.2 Synthesis of [Zn9(mbpdc)7(3,3′-dmbpy)23-OH)4]·(H2O)5}n (1) General procedure: The pH of H2mbpdc (0.128g, 0.5mmol) hot aqueous solution (10mL) was adjusted to 7-8 with NaOH. Then Zn(NO3)2·6H2O (0.148g, 0.5mmol) and 3,3′-dmbpy (0.046g, 0.25mmol) were added in above aqueous solution. The resulting mixture were sealed in a 23mL Teflon-lined stainless steel autoclave and heated at 130C for 3days under autogenous pressure. Colorless crystals were obtained in a yield of 58% based on mbpdc.
  • 20
  • [ 1186048-28-1 ]
  • 4,4'-dimethyl 2-([(1H-1,2,3,4-tetrazol-5-yl)methyl]amino}methyl)-[1,1'-biphenyl]-4,4'-dicarboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: sulfuric acid / 12 h / 80 °C / Reflux 2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 10.5 h / 20 - 80 °C / Inert atmosphere 3: silver nitrate / ethyl methyl ether; water / 24 h / 20 °C 4: sodium cyanoborohydride / methanol / 10 h / 20 °C / Reflux
  • 21
  • [ 1186048-28-1 ]
  • 2-([(1H-1,2,3,4-tetrazol-5-yl)methyl]amino}methyl)-[1,1'-biphenyl]-4,4'-dicarboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: sulfuric acid / 12 h / 80 °C / Reflux 2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 10.5 h / 20 - 80 °C / Inert atmosphere 3: silver nitrate / ethyl methyl ether; water / 24 h / 20 °C 4: sodium cyanoborohydride / methanol / 10 h / 20 °C / Reflux 5: sodium hydroxide / water; tetrahydrofuran / 5 h / Reflux
  • 22
  • [ 1186048-28-1 ]
  • 4,4'-dimethyl 2-(dibromomethyl)-[1,1'-biphenyl]-4,4'-dicarboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sulfuric acid / 12 h / 80 °C / Reflux 2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 10.5 h / 20 - 80 °C / Inert atmosphere
  • 23
  • [ 1186048-28-1 ]
  • dimethyl 2-formyl-[1,1′-biphenyl]-4,4′-dicarboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: sulfuric acid / 12 h / 80 °C / Reflux 2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 10.5 h / 20 - 80 °C / Inert atmosphere 3: silver nitrate / ethyl methyl ether; water / 24 h / 20 °C
Recommend Products
Same Skeleton Products
Historical Records

Related Functional Groups of
[ 1186048-28-1 ]

Aryls

Chemical Structure| 1181626-10-7

[ 1181626-10-7 ]

2',5'-Dimethyl-[1,1'-biphenyl]-3-carboxylic acid

Similarity: 1.00

Chemical Structure| 178313-67-2

[ 178313-67-2 ]

2-Methyl-[1,1'-biphenyl]-4-carboxylic acid

Similarity: 1.00

Chemical Structure| 955929-56-3

[ 955929-56-3 ]

2',6'-Dimethyl-[1,1'-biphenyl]-3-carboxylic acid

Similarity: 1.00

Chemical Structure| 1261971-14-5

[ 1261971-14-5 ]

2,3',5'-Trimethyl-[1,1'-biphenyl]-4-carboxylic acid

Similarity: 1.00

Chemical Structure| 1170833-71-2

[ 1170833-71-2 ]

2',4'-Dimethyl-[1,1'-biphenyl]-4-carboxylic acid

Similarity: 1.00

Carboxylic Acids

Chemical Structure| 1181626-10-7

[ 1181626-10-7 ]

2',5'-Dimethyl-[1,1'-biphenyl]-3-carboxylic acid

Similarity: 1.00

Chemical Structure| 178313-67-2

[ 178313-67-2 ]

2-Methyl-[1,1'-biphenyl]-4-carboxylic acid

Similarity: 1.00

Chemical Structure| 955929-56-3

[ 955929-56-3 ]

2',6'-Dimethyl-[1,1'-biphenyl]-3-carboxylic acid

Similarity: 1.00

Chemical Structure| 1261971-14-5

[ 1261971-14-5 ]

2,3',5'-Trimethyl-[1,1'-biphenyl]-4-carboxylic acid

Similarity: 1.00

Chemical Structure| 1170833-71-2

[ 1170833-71-2 ]

2',4'-Dimethyl-[1,1'-biphenyl]-4-carboxylic acid

Similarity: 1.00