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[ CAS No. 1187933-36-3 ] {[proInfo.proName]}

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Chemical Structure| 1187933-36-3
Chemical Structure| 1187933-36-3
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Product Details of [ 1187933-36-3 ]

CAS No. :1187933-36-3 MDL No. :MFCD12913831
Formula : C11H12BrNO Boiling Point : -
Linear Structure Formula :- InChI Key :HXBUGZUYESCKQM-UHFFFAOYSA-N
M.W : 254.12 Pubchem ID :53408510
Synonyms :

Safety of [ 1187933-36-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1187933-36-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1187933-36-3 ]

[ 1187933-36-3 ] Synthesis Path-Downstream   1~16

  • 1
  • [ 1187933-36-3 ]
  • [ 1187933-50-1 ]
YieldReaction ConditionsOperation in experiment
8.96 g With borane-THF In toluene at 0℃; for 4h; Inert atmosphere; Reflux;
  • 2
  • [ 1187933-36-3 ]
  • [ 2744170-60-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: borane-THF / toluene / 4 h / 0 °C / Inert atmosphere; Reflux 2: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 5 h / 90 °C / Inert atmosphere
  • 3
  • [ 1187933-36-3 ]
  • [ 2744170-61-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: borane-THF / toluene / 4 h / 0 °C / Inert atmosphere; Reflux 2: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 5 h / 90 °C / Inert atmosphere
  • 4
  • [ 1187933-36-3 ]
  • [ 2744170-62-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: borane-THF / toluene / 4 h / 0 °C / Inert atmosphere; Reflux 2.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 5 h / 90 °C / Inert atmosphere 3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / 1,2-dichloro-ethane / 2 h / 80 °C / Inert atmosphere 3.2: 0.25 h / Inert atmosphere 3.3: 2 h / 20 °C / Inert atmosphere
  • 5
  • [ 1187933-36-3 ]
  • [ 2744170-63-4 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: borane-THF / toluene / 4 h / 0 °C / Inert atmosphere; Reflux 2.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 5 h / 90 °C / Inert atmosphere 3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / 1,2-dichloro-ethane / 2 h / 80 °C / Inert atmosphere 3.2: 0.25 h / Inert atmosphere 3.3: 2 h / 20 °C / Inert atmosphere
  • 6
  • [ 1187933-36-3 ]
  • [ 2744170-64-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: borane-THF / toluene / 4 h / 0 °C / Inert atmosphere; Reflux 2.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 5 h / 90 °C / Inert atmosphere 3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / 1,2-dichloro-ethane / 2 h / 80 °C / Inert atmosphere 3.2: 0.25 h / Inert atmosphere 3.3: 2 h / 20 °C / Inert atmosphere 4.1: potassium <i>tert</i>-butylate / dimethyl sulfoxide / 20 °C
Multi-step reaction with 4 steps 1.1: borane-THF / toluene / 4 h / 0 °C / Inert atmosphere; Reflux 2.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 5 h / 90 °C / Inert atmosphere 3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / 1,2-dichloro-ethane / 2 h / 80 °C / Inert atmosphere 3.2: 0.25 h / Inert atmosphere 3.3: 2 h / 20 °C / Inert atmosphere 4.1: potassium <i>tert</i>-butylate / dimethyl sulfoxide / 20 °C
  • 7
  • [ 615-36-1 ]
  • [ 1187933-36-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: pyridine / 5 h / 0 - 20 °C / Inert atmosphere 2: aluminum (III) chloride / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere
  • 8
  • [ 3350-78-5 ]
  • [ 1187933-36-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: pyridine / 5 h / 0 - 20 °C / Inert atmosphere 2: aluminum (III) chloride / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere
  • 9
  • [ 102804-45-5 ]
  • [ 1187933-36-3 ]
YieldReaction ConditionsOperation in experiment
18.85 g With aluminum (III) chloride In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere;
  • 10
  • [ 28342-75-8 ]
  • [ 1187933-36-3 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
84.4% With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 8h; Inert atmosphere; 5 Synthesis of intermediate 3: General procedure: At nitrogen protection atmosphere, in a dry three-mouth flask, respectively, add 1.1mmol intermediate 1 and 1mmol intermediate 2, pour 100ml dmf as a solvent, add dry K2CO3 as a base, react at 120 °C for 8 hours, TLC monitor the reaction, after the reaction is complete, the reaction liquid is cooled to room temperature, add water and dichloromethane in turn, wash the reaction liquid with water multiple times, At the same time, the aqueous phase was extracted with dichloromethane and ethyl acetatefor many times, the organic phase was combined, dried with anhydrous Na2 CO3, filtered, and the reaction liquid was dried to obtain a crude product, and the molar amount of intermediate 3 was obtained by recrystallization of ethyl acetate and petroleum ether was 0.76mmol, the reaction yield was: 76%,
  • 11
  • [ 28342-75-8 ]
  • [ 1187933-36-3 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 120 °C / Inert atmosphere 2: potassium carbonate; palladium diacetate; tri-tert-butyl phosphine / 12 h / 80 °C / Inert atmosphere
  • 12
  • [ 1187933-36-3 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 120 °C / Inert atmosphere 2: o-dimethylbenzene / 4 h / 120 °C / Inert atmosphere
  • 13
  • [ 1187933-36-3 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 120 °C / Inert atmosphere 2: o-dimethylbenzene / 4 h / 120 °C / Inert atmosphere 3: iron(0); ammonia hydrochloride; hydrogenchloride; lithium hydroxide monohydrate; methanol / tetrahydrofuran
  • 14
  • [ 1187933-36-3 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 120 °C / Inert atmosphere 2: o-dimethylbenzene / 4 h / 120 °C / Inert atmosphere 3: iron(0); ammonia hydrochloride; hydrogenchloride; lithium hydroxide monohydrate; methanol / tetrahydrofuran 4: palladium diacetate; tri-tert-butyl phosphine / toluene / 105 °C / Inert atmosphere; Alkaline conditions
  • 15
  • [ 1187933-36-3 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 120 °C / Inert atmosphere 2: o-dimethylbenzene / 4 h / 120 °C / Inert atmosphere 3: iron(0); ammonia hydrochloride; hydrogenchloride; lithium hydroxide monohydrate; methanol / tetrahydrofuran 4: palladium diacetate; tri-tert-butyl phosphine / toluene / 105 °C / Inert atmosphere; Alkaline conditions 5: potassium carbonate; palladium diacetate; tri-tert-butyl phosphine / 12 h / 80 °C / Inert atmosphere
  • 16
  • [ 327-92-4 ]
  • [ 1187933-36-3 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
84.4% With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 8h; Inert atmosphere; 7 Synthesis of intermediate 3: General procedure: At nitrogen protection atmosphere, in a dry three-mouth flask, respectively, add 1.1mmol intermediate 1 and 1mmol intermediate 2, pour 100ml dmf as a solvent, add dry K2CO3 as a base, react at 120 °C for 8 hours, TLC monitor the reaction, after the reaction is complete, the reaction liquid is cooled to room temperature, add water and dichloromethane in turn, wash the reaction liquid with water multiple times, At the same time, the aqueous phase was extracted with dichloromethane and ethyl acetatefor many times, the organic phase was combined, dried with anhydrous Na2 CO3, filtered, and the reaction liquid was dried to obtain a crude product, and the molar amount of intermediate 3 was obtained by recrystallization of ethyl acetate and petroleum ether was 0.76mmol, the reaction yield was: 76%,
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Technical Information

• 1,4-Addition of an Amine to a Conjugated Enone • 1,4-Additions of Organometallic Reagents • Acetal Formation • Acid-Catalyzed α -Halogenation of Ketones • Acyl Group Substitution • Add Hydrogen Cyanide to Aldehydes and Ketones to Produce Alcohols • Addition of a Hydrogen Halide to an Internal Alkyne • Alcohol Syntheses from Aldehydes, Ketones and Organometallics • Alcohols from Haloalkanes by Acetate Substitution-Hydrolysis • Alcohols React with PX3 • Aldehydes and Ketones Form Hemiacetals Reversibly • Aldehydes May Made by Terminal Alkynes Though Hydroboration-oxidation • Aldol Addition • Aldol Condensation • Alkenes React with Ozone to Produce Carbonyl Compounds • Alkyl Halide Occurrence • Alkylation of Aldehydes or Ketones • Alkylation of an Alkynyl Anion • Alkylation of Enolate Ions • Amide Hydrolysis • Amide Hydrolysis • Amides Can Be Converted into Aldehydes • Amines Convert Acyl Chlorides into Amides • An Alkane are Prepared from an Haloalkane • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Base-Catalyzed Hydration of α,β -Unsaturated Aldehydes and Ketones • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Chan-Lam Coupling Reaction • Claisen Condensations Produce β-Dicarbonyl Compounds • Claisen Condensations Produce β-Dicarbonyl Compounds • Clemmensen Reduction • Complex Metal Hydride Reductions • Conjugated Enone Takes Part in 1,4-Additions • Convert Haloalkanes into Alcohols by SN2 • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Cyanohydrins can be Convert to Carbonyl Compounds under Basic Conditions • Decarboxylation of 3-Ketoacids Yields Ketones • Decarboxylation of Substituted Propanedioic • Deoxygenation of the Carbonyl Group • Deprotonation of a Carbonyl Compound at the α -Carbon • Diorganocuprates Convert Acyl Chlorides into Ketones • Dithioacetal Formation • Enamines Can Be Used to Prepare Alkylated Aldehydes • Enol-Keto Equilibration • Enolate Ions Are Protonated to Form ketones • Exclusive 1,4-Addition of a Lithium Organocuprate • Fischer Indole Synthesis • Formation of an Amide from an Amine and a Carboxylic Acid • Formation of an Amide from an Amine and a Carboxylic Acid • Friedel-Crafts Alkylation of Benzene with Haloalkanes • Furan Hydrolyzes to Dicarbonyl Compounds • Geminal Diols and Acetals Can Be Hydrolyzed to Carbonyl Compounds • General Reactivity • Grignard Reaction • Halogenation of Alkenes • Hantzsch Pyridine Synthesis • Hemiaminal Formation from Amines and Aldehydes or Ketones • Hemiaminal Formation from Amines and Aldehydes or Ketones • Henry Nitroaldol Reaction • HIO4 Oxidatively Degrades Vicinal Diols to Give Carbonyl Derivatives • Hiyama Cross-Coupling Reaction • Hofmann Rearrangement • Horner-Wadsworth-Emmons Reaction • Hydration of the Carbonyl Group • Hydride Reductions • Hydride Reductions of Aldehydes and Ketones to Alcohols • Hydride Reductions of Aldehydes and Ketones to Alcohols • Hydrogenation by Palladium on Carbon Gives the Saturated Carbonyl Compound • Hydrolysis of Imines to Aldehydes and Ketones • Imine Formation from Amines and Aldehydes or Ketones • Isomerization of β, γ -Unsaturated Carbonyl Compounds • Ketone Synthesis from Nitriles • Ketones Undergo Mixed Claisen Reactions to Form β-Dicarbonyl Compounds • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • Lithium Organocuprate may Add to the α ,β -Unsaturated Carbonyl Function in 1,4-Fashion • Mannich Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mercury Ions Catalyze Alkynes to Ketones • Methylation of Ammonia • Methylation of Ammonia • Michael Addition • Oxidation of Alcohols to Carbonyl Compounds • Oxidation of Alkyl-substituted Benzenes Gives Aromatic Ketones • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Phenylhydrazone and Phenylosazone Formation • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Prins Reaction • Pyrroles, Furans, and Thiophenes are Prepared from γ-Dicarbonyl Compounds • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Dihalides • Reduction of an Amide to an Amine • Reduction of an Amide to an Amine • Reductive Amination • Reductive Amination • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Stille Coupling • Stobbe Condensation • Strecker Synthesis • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • The Acylium Ion Attack Benzene to Form Phenyl Ketones • The Claisen Rearrangement • The Reaction of Alkynyl Anions with Carbonyl Derivatives • The Wittig Reaction • Thiazolium Salt Catalysis in Aldehyde Coupling • Thiazolium Salts Catalyze Aldehyde Coupling • Thiazolium Salts Catalyze Aldehyde Coupling • Ugi Reaction • Use 1,3-dithiane to Prepare of α-Hydroxyketones • Williamson Ether Syntheses • Wittig Reaction • Wolff-Kishner Reduction
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