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[ CAS No. 1191-62-4 ] {[proInfo.proName]}

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3d Animation Molecule Structure of 1191-62-4
Chemical Structure| 1191-62-4
Chemical Structure| 1191-62-4
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Product Details of [ 1191-62-4 ]

CAS No. :1191-62-4 MDL No. :MFCD00003574
Formula : C8H18S2 Boiling Point : -
Linear Structure Formula :- InChI Key :PGTWZHXOSWQKCY-UHFFFAOYSA-N
M.W : 178.36 Pubchem ID :14493
Synonyms :

Calculated chemistry of [ 1191-62-4 ]

Physicochemical Properties

Num. heavy atoms : 10
Num. arom. heavy atoms : 0
Fraction Csp3 : 1.0
Num. rotatable bonds : 7
Num. H-bond acceptors : 0.0
Num. H-bond donors : 0.0
Molar Refractivity : 56.43
TPSA : 77.6 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -5.04 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.72
Log Po/w (XLOGP3) : 3.31
Log Po/w (WLOGP) : 3.19
Log Po/w (MLOGP) : 3.29
Log Po/w (SILICOS-IT) : 3.14
Consensus Log Po/w : 3.13

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.57
Solubility : 0.481 mg/ml ; 0.0027 mol/l
Class : Soluble
Log S (Ali) : -4.62
Solubility : 0.00432 mg/ml ; 0.0000242 mol/l
Class : Moderately soluble
Log S (SILICOS-IT) : -3.34
Solubility : 0.0821 mg/ml ; 0.00046 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 2.36

Safety of [ 1191-62-4 ]

Signal Word:Danger Class:9
Precautionary Statements:P501-P273-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 UN#:3334
Hazard Statements:H315-H319-H413-H372 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1191-62-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1191-62-4 ]

[ 1191-62-4 ] Synthesis Path-Downstream   1~75

  • 2
  • [ 1191-62-4 ]
  • [ 2437-56-1 ]
  • 1,8-bis-tridecylmercapto-octane [ No CAS ]
  • 4
  • [ 1191-62-4 ]
  • [ 528-76-7 ]
  • 1,8-bis-(2,4-dinitro-phenyldisulfanyl)-octane [ No CAS ]
  • 5
  • [ 1191-62-4 ]
  • [ 97-00-7 ]
  • 1,8-bis-(2,4-dinitro-phenylsulfanyl)-octane [ No CAS ]
  • 6
  • [ 2554-62-3 ]
  • [ 1191-62-4 ]
  • [ 38484-49-0 ]
  • 7
  • [ 1191-62-4 ]
  • [ 26555-40-8 ]
  • [ 71370-16-6 ]
  • 8
  • [ 1191-62-4 ]
  • [ 29176-55-4 ]
  • [ 64765-44-2 ]
  • 9
  • [ 1191-62-4 ]
  • [ 53344-72-2 ]
  • [ 64765-55-5 ]
  • 11
  • [ 1191-62-4 ]
  • [ 31352-40-6 ]
  • [ 89506-77-4 ]
  • 12
  • [ 1191-62-4 ]
  • [ 114038-66-3 ]
  • [ 114038-72-1 ]
  • 13
  • [ 1191-62-4 ]
  • [ 83492-42-6 ]
  • [ 84944-22-9 ]
  • 14
  • [ 1191-62-4 ]
  • [ 107170-96-7 ]
  • [ 107170-98-9 ]
  • 15
  • [ 98194-94-6 ]
  • [ 1191-62-4 ]
  • 16
  • [ 1191-62-4 ]
  • [ 121012-95-1 ]
  • [ 121013-04-5 ]
  • 17
  • [ 1191-62-4 ]
  • [ 24463-19-2 ]
  • [ 68520-85-4 ]
  • 18
  • [ 1191-62-4 ]
  • [ 67217-55-4 ]
  • 1,8-di(6I-thiocyclomaltoheptaos-6I-S-yl)octane [ No CAS ]
  • 20
  • [ 60-29-7 ]
  • [ 1191-62-4 ]
  • [ 7705-08-0 ]
  • [ 64-19-7 ]
  • [ 6573-66-6 ]
  • 21
  • [ 629-41-4 ]
  • [ 1191-62-4 ]
  • 22
  • [ 1191-62-4 ]
  • 1-(tert-butylimino-methyl)-1,3-dimethylurea hydrochloride [ No CAS ]
  • S-(8-sulfanyloctyl) methylthiolcarbamate [ No CAS ]
  • 23
  • [ 1191-62-4 ]
  • [ 42298-28-2 ]
  • 8-(anthracen-2-ylsulfanyl)-octane-1-thiol [ No CAS ]
  • 24
  • [ 1191-62-4 ]
  • [ 51790-19-3 ]
  • C44H48S4 [ No CAS ]
  • 25
  • [ 1191-62-4 ]
  • [ 35168-62-8 ]
  • C18H28S2 [ No CAS ]
  • 26
  • [ 1191-62-4 ]
  • [ 89506-82-1 ]
  • 27
  • [ 629-03-8 ]
  • [ 1191-62-4 ]
  • 28
  • [ 1191-62-4 ]
  • [ 114038-83-4 ]
  • 29
  • [ 1191-62-4 ]
  • [ 114038-82-3 ]
  • 30
  • [ 1191-62-4 ]
  • [ 107196-78-1 ]
  • 31
  • [ 1191-62-4 ]
  • [ 107171-02-8 ]
  • 32
  • [ 1191-62-4 ]
  • C8H17NOS2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Dithiol compounds [IV] used are as follows: 1,4-dimercaptobutane, 1,6-dimercaptohexane, 1,8-dimercaptooctane, 1,9-dimercaptononane, di(2-mercapto-ethyl)-ether, dithioerythritol and dithiothreitol.
  • 34
  • [ 1191-62-4 ]
  • [ 74-88-4 ]
  • 2.11-Dithiadodecane [ No CAS ]
YieldReaction ConditionsOperation in experiment
45% With n-butyllithium; 2.11-Dithiadodecane (Compound 9): The reaction is carried out as described in Method A using <strong>[1191-62-4]1,8-octanedithiol</strong> (2.0 g, 11.2 mmol), n-butyllithium (9.0 ml, 22.4 mmol, 2.5 M) and iodomethane (3.20g, 22.4 mmol) as reagents. The reaction gives 2,11-dithiadodecane (1.44 g, 55% crude yield). The Kugelrohr distillation is carried out at 0.1 mbar and the fraction (1.176 g) with a boiling point of 100C is pure 2,11-dithiadodecane, isolated in a yield of 45%. Its characterising spectroscopic data are: δH1.34 (8H, m, SCH2CH2CH2), 1.60 (4H, m, SCH2CH2), 2.10 (6H, s, SCH3), 2.49 (4H, t, J7.4,SCH2), δc15.53 (CH3), 28.72, 29.11 (CH2), 34.26 (SCH2)
  • 35
  • [ 109-65-9 ]
  • [ 1191-62-4 ]
  • 1,8-bis-butylsulfanyl-octane [ No CAS ]
YieldReaction ConditionsOperation in experiment
78% With n-butyllithium; 5,14-Dithiaoctadecane (Compound 16): The reaction is carried out as described in Method A using <strong>[1191-62-4]1,8-octanedithiol</strong> (2.0 g, 11.2 mmol), n-butyllithium (9 ml, 22 mmol, 2.5M) and 1-bromobutane (3.07 g, 22.4 mmol) as reagents. The reaction gives 5,14-dithiaoctadecane (2.91 g, 86% crude yield). The Kugelrohr distillation is carried out at 0.1 mbar and the fraction (2.523 g) with a boiling point of 140C is pure 5,14-dithiaoctadecane, isolated in a yield of 78%. Its characterising spectroscopic data are: δH0.92 (6H, t, J7.3, CH3), 1.37 (12H, m, CH2), 1.58 (8H, m, SCH2CH2), 2.50 (8H, m, SCH2), δc13.71 (CH3), 22.04, 28.86, 29.12, 29.66 (CH2), 31.81 (SCH2CH2), 32.12 (SCH2).
  • 36
  • ammonium hexafluorophosphate [ No CAS ]
  • η-cyclopentadienyl-η-1,4-dichlorobenzeneiron(II) hexafluorophosphate [ No CAS ]
  • [ 1191-62-4 ]
  • [(η(5)-C5H5)Fe(4-ClC6H4S(CH2)8C6H4Cl-4)Fe(η(5)-C5H5)](PF6)2 [ No CAS ]
  • 37
  • decacarbonyl-1κ(4)C,2κ(3)C,3κ(3)C-μ-hydrido-2:3κ(2)H-μ-hydroxy-2:3κ(2)O-trisosmium-(3 Os-Os) [ No CAS ]
  • [ 1191-62-4 ]
  • [ 1024616-74-7 ]
  • [ 1024616-92-9 ]
  • 38
  • [ 52056-69-6 ]
  • [ 1191-62-4 ]
  • [ 1062539-30-3 ]
  • 39
  • [ 1683-96-1 ]
  • [ 1191-62-4 ]
  • [ 1198800-09-7 ]
  • 40
  • [ 1191-62-4 ]
  • [ 108-24-7 ]
  • [ 351003-17-3 ]
  • 41
  • [ 1191-62-4 ]
  • [ 868248-05-9 ]
  • C84H112N4S2(2+)*2I(1-) [ No CAS ]
  • 42
  • [ 1191-62-4 ]
  • [ 308810-29-9 ]
  • C100H120N4S2(2+)*2I(1-) [ No CAS ]
  • 43
  • [ 1191-62-4 ]
  • [ 35168-62-8 ]
  • C18H28S2 [ No CAS ]
  • C18H28S2 [ No CAS ]
  • 44
  • [ 936616-94-3 ]
  • [ 1191-62-4 ]
  • tert-butyl 2,2'-(1,1'-(12,12'-(octane-1,8-diylbis(sulfanediyl))bis(dodecane-12,1-diyl))bis(3-(2-amino-2-oxoacetyl)-2-methyl-1H-indole-4,1-diyl))bis(oxy)diacetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
58% l . la ..W'.5: TOMP ta lD (5-26)3[00400] The t-Bu protected compound fert-Butyl 2,2'-(1,1'-(12,12'-(octane-1,8- diylbis(sulfanediyl))bis(dodecane-12,1-diyl))bis(3-(2-amino-2-oxoacetyl)-2-methyl-1H- indole-4,1-diyl))bis(oxy)diacetate, 2 was prepared as follows.[00401] 1 ,8-Octanedithiol (0.115 mL, 0.62 mmole) was added to 95% sodium hydride (0.035 g, 1.38 mmole) in dry DMF (3 mL), at O0C under nitrogen. After 0.5 h this mixture was added to the bromide 1 (0.760 g, 1.31 mmole) (prepared as in Example 11B) in dry DMF (9 mL), at O0C under nitrogen. The reaction was maintained at O0C for 9 h and slowly warmed to room temperature overnight. The mixture was cooled to O0C, quenched with ammonium chloride solution (10 mL), diluted with dichloromethane (100 mL) and washed with s ammonium chloride solution (2 x 50 mL). The organic phase was separated and the aqueous phase extracted with dichloromethane (3 x 30 mL). The combined organic phase was dried (Na2SO4), filtered and evaporated to a brown syrup. Purification by chromatography over silica gel, using chloroform/ethyl acetate (2:1 to 1 :1 ) as the eluant, gave the product as yellow solid (0.422 g, 58%).
58% 1,8-Octanedithiol (0.115 mL, 0.62 mmole) was added to 95% sodium hydride (0.035 g, 1.38 mmole) in dry DMF (3 mL), at 0 C. under nitrogen. After 0.5 h this mixture was added to the bromide 1 (0.760 g, 1.31 mmole) (prepared as in Example 11B) in dry DMF (9 mL), at 0 C. under nitrogen. The reaction was maintained at 0 C. for 9 h and slowly warmed to room temperature overnight. The mixture was cooled to 0 C., quenched with ammonium chloride solution (10 mL), diluted with dichloromethane (100 mL) and washed with ammonium chloride solution (2×50 mL). The organic phase was separated and the aqueous phase extracted with dichloromethane (3×30 mL). The combined organic phase was dried (Na2SO4), filtered and evaporated to a brown syrup. Purification by chromatography over silica gel, using chloroform/ethyl acetate (2:1 to 1:1) as the eluant, gave the product as yellow solid (0.422 g, 58%).
  • 45
  • [ 936616-93-2 ]
  • [ 1191-62-4 ]
  • tert-butyl 2,2'-(1,1'-(8,8'-(octane-1,8-diylbis(sulfanediyl))bis(octane-8,1-diyl))bis(3-(2-amino-2-oxoacetyl)-2-methyl-1H-indole-4,1-diyl))bis(oxy)diacetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
32% EXAMPLE 11.6: COMPOUND (5-24)[00404] The t-Bu protected compound ferf-Butyl 2,2'-(1 ,1'-(8,8>-(octane-1 ,8- diylbis(sulfanediyl))bis(octane-8, 1 -diyl))bis(3-(2-amino-2-oxoacetyl)-2-methyl-1 H-indole-4, 1 - diyl))bis(oxy)diacetate, 2 was prepared as follows.[00405] 1 ,8-Octanedithiol (0.73 mL, 3.94 mmole) was added to sodium hydride (0.21 g, 8.75 mmole) in dry DMF (12 mL), at O0C under nitrogen. After 0.5 h this mixture was added to the bromide 1 (4.3 g, 8.21 mmole) (prepared as in Example 11A) in dry DMF (20 mL), at O0C under nitrogen. The reaction was maintained at O0C for 8 h and stored in the freezer overnight. The mixture was cooled to O0C, quenched with ammonium chloride solution (15 <n="159"/>_ n wa (50 mL). The organic phase was separated and the aqueous phase extracted with dichloromethane (2 x 25 mL). The combined organic phase was washed with brine (75 mL) dried (Na2SO4), filtered and evaporated to a yellow/orange syrup. Purification by chromatography over silica gel, using chloroform/ethyl acetate (2:1 to 3:2) as the eluant, gave the product as yellow solid (2.79 g, 32%).
32% 1,8-Octanedithiol (0.73 mL, 3.94 mmole) was added to sodium hydride (0.21 g, 8.75 mmole) in dry DMF (12 mL), at 0 C. under nitrogen. After 0.5 h this mixture was added to the bromide 1 (4.3 g, 8.21 mmole) (prepared as in Example 11A) in dry DMF (20 mL), at 0 C. under nitrogen. The reaction was maintained at 0 C. for 8 h and stored in the freezer overnight. The mixture was cooled to 0 C., quenched with ammonium chloride solution (15 mL), diluted with dichloromethane (100 mL) and washed with ammonium chloride solution (50 mL). The organic phase was separated and the aqueous phase extracted with dichloromethane (2×25 mL). The combined organic phase was washed with brine (75 mL) dried (Na2SO4), filtered and evaporated to a yellow/orange syrup. Purification by chromatography over silica gel, using chloroform/ethyl acetate (2:1 to 3:2) as the eluant, gave the product as yellow solid (2.79 g, 32%).
  • 47
  • [ 1191-62-4 ]
  • [ 118-75-2 ]
  • [ 1254938-21-0 ]
  • 48
  • [ 1191-62-4 ]
  • [ 6959-47-3 ]
  • [ 1349076-24-9 ]
  • 49
  • [ 1073-67-2 ]
  • [ 1191-62-4 ]
  • [ 1370435-87-2 ]
  • 50
  • [ 117-80-6 ]
  • [ 1191-62-4 ]
  • [ 1393725-41-1 ]
  • [ 1393725-42-2 ]
  • 51
  • [ 1191-62-4 ]
  • [ 69-72-7 ]
  • C15H22O2S2 [ No CAS ]
  • 52
  • [ 1191-62-4 ]
  • C21H33BrO2S2 [ No CAS ]
  • 53
  • [ 1191-62-4 ]
  • C29H37N3O3S2 [ No CAS ]
  • 54
  • [ 1191-62-4 ]
  • [ 67217-55-4 ]
  • C50H86O34S2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
69% With sodium carbonate; In methanol; water; at 50℃; for 20h;Inert atmosphere; General procedure: Tosyl cyclodextrin 1 (300 mg, 0.23 mmol) was suspended in a mixture of methanol (15 mL), water (15 mL),and sodium carbonate (62 mg, 2.5 equiv) under an inert atmosphere. To remove dissolved oxygen, argon was bubbled through this mixture in advance (2 minutes), exposed to ultrasound (10 minutes) and bubbled by argon again (10 minutes). Then the dithiol (9.5 equiv) was added to the solution, which was then stirred under a condenser and an inert atmosphere at 50 C for 20 hours. The reaction process was monitored by TLC (BuOH/EtOH/H2O 5/4/4,detection by H2SO4). After cooling to room temperature, the reaction mixture was neutralized by addition of hydrochloric acid (5% aqueous solution). After dilution of the reaction mixture to double volume by addition of water, unreacted dithiol was removed by extraction with chloroform (3 × 1:1). The solvents of the water layer were evaporated under reduced pressure. The solid residue was adsorbed on silica gel (10 × weight of the residue) and purified by column chromatography on silica gel (200 × weight of the residue).
  • 55
  • [ 1191-62-4 ]
  • C30H56N2O9 [ No CAS ]
  • (2R,3S,4R,5R,8R,10R,11R,12R,13R,14R)-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2-ethyl-3,4,10,13-tetrahydroxy-13-(8-thioloctylmercaptomethyl)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
0.16 g In toluene; at 60℃; for 72h; General procedure: The compound 6 was dissolved in the above general formula 500mg 5mL of toluene. To this was added excess 1 (2) 3 and 0. 7mL isopropanethiol. 60 C reaction 46h, the reaction was completed by TLC. Add saturated NaHCO3 f stop the reaction, and extracted with 3X50mL methylene chloride, and the combined organic phase was dried over anhydrous sodium sulfate, filtered, and the filtrate was evaporated to give the crude product. It was further purified by silica gel column chromatography (methylene chloride: methanol: aqueous ammonia = 100: 2: 0.2) to give 0. 12g of the title compound. Example 171 "isopropyl mercaptan" to use "1,8_ octanedithiol", and the reaction time from 46h to change To 3 days, and the rest with Example 171. Finally obtained the title compound 0. 16g
  • 56
  • C10H22N4S2*2H(1+) [ No CAS ]
  • [ 1191-62-4 ]
  • 57
  • [ 1191-62-4 ]
  • [ 6573-66-6 ]
  • 1,2,11,12-tetrathiacycloicosane [ No CAS ]
  • 58
  • [ 1191-62-4 ]
  • C14H16Fe2O6S2 [ No CAS ]
  • 59
  • [ 1191-62-4 ]
  • C22H32Fe2O6S4 [ No CAS ]
  • 60
  • [ 50-00-0 ]
  • [ 1191-62-4 ]
  • [ 364-76-1 ]
  • 3-(4-fluoro-3-nitrophenyl)-1,5-dithia-3-azacyclotridecane [ No CAS ]
YieldReaction ConditionsOperation in experiment
56% General procedure: A mixture ofthe appropriate α,ω-dithiol (1 mmol) and 37% formalin(0.15 ml, 2 mmol) was stirred for 30 min at roomtemperature. Then a solution of nitroaniline 4f,g (1 mmol) and SmCl3·6H2O (0.02 g, 5 mol %) in 5 ml of suitable solvent (compound 4f - CHCl3, compound 4g - Me2CO) was added dropwise. The mixture was stirred for 3-4 h at 40C, then evaporated on a rotary evaporator. The product was purified by column chromatography.
  • 61
  • [ 1191-62-4 ]
  • dipotassium octane-1,8-dithiolate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium tert-butylate; In ethanol; at 0℃; for 2h; To synthesize the dithiolate solution, 2.25 g (20 mmol) potassium tert-butanolate is suspended in 60 mL absolute ethanol, cooled to 00 C., and then a solution consisting of 1.78 g (10 mmol) octane-i,8-dithiol in 20 mL absolute ethanol is added slowly by drops. Next the mixture is stirred further for 2 hours while cooling with ice.
  • 62
  • C8H16S2(2-)*2Na(1+) [ No CAS ]
  • [ 1191-62-4 ]
YieldReaction ConditionsOperation in experiment
13.2 g With hydrogenchloride; In water; 27.20 g (0.1 mol) 1,8-dibromooctane and 16.73 g (0.22 mol) thiourea are heated at reflux for 10 hours in 10 mL 95% ethanol. The precipitate formed on cooling is filtered with suction and washed with a small amount of ethanol. For saponification, the dithiouronium salt is added to 120 mL SN sodium hydroxide solution and heated at reflux for 2 hours. Next the reaction mixture is acidified with 2N hydrochloric acid, and the aqueous phase is separated from the dithiol phase. The dithiol is dried over sodium sulfate and then filtered out. The filter residue is washed several times with diethyl ether, and the ether phases are combined with the dithiol phase, concentrated and dried over phosphorus pentoxide. This yields 13.20 g raw product of octane-1,8- dithiol. Before being used further, the corresponding amount is purified by column chromatography.
  • 63
  • [ 1191-62-4 ]
  • 1,8-bis(chlorosulfanyl)octane [ No CAS ]
YieldReaction ConditionsOperation in experiment
With chlorine; at -5 - 10℃; for 2h; Adding 0.5 mol of 1,8-didecyloctane and naphthenic oil to the reaction kettle,Dilute and lower the 1,8-dimercaptooctane to -5 to 10 C,Then, 0.75 mol of chlorine gas was introduced to carry out the reaction.The temperature was maintained between -5 and 10 C for a period of 2 hours.
  • 64
  • [ 1191-62-4 ]
  • 2-(4-cyanobenzyl)-1-methoxypersulfide [ No CAS ]
  • C24H28N2S6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
85% With tris(pentafluorophenyl)borate; In dichloromethane; at 20℃; for 5h;Inert atmosphere; Green chemistry; 1a (42.3 mg, 0.2 mmol), <strong>[1191-62-4]1,8-octanedithiol</strong> 2s (19.6mg, 0.11mmol), B(C6F5)3 (2.6mg, 0.005mmol), dichloromethane (2.0mL) were sequentially added to the reaction tube under a nitrogen atmosphere. the reaction system was stirred at normal temperature for 5 hours, after the reaction was completed Diluted with dichloromethane, the solvent was removed, and the column was chromatographed to give a colorless liquid compound 3s (46.1 mg, 85%)
  • 65
  • [ 1191-62-4 ]
  • C48H88O7Si5 [ No CAS ]
  • C53H100O6S2Si5 [ No CAS ]
  • 66
  • [ 1191-62-4 ]
  • (–)-vescalin [ No CAS ]
  • C55H58N4O21S3 [ No CAS ]
  • 67
  • [ 1191-62-4 ]
  • (–)-vescalin [ No CAS ]
  • C35H36O17S2 [ No CAS ]
  • 68
  • [ 1191-62-4 ]
  • [ 108-24-7 ]
  • [ 351003-17-3 ]
  • S-(8-mercaptooctyl)ethanethioate [ No CAS ]
  • 69
  • [ 1191-62-4 ]
  • [ 65094-22-6 ]
  • C10H18F4S2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
38% General procedure: The starting material (2 mmol) was added to a sealed tube holding 20 mL of a 1:1 mixture of acetonitrile/water and KOH (40 mmol), whichwas cooled using an ice bath. The mixture was vigorously mixed for 15min and then phosphonate 1 (4 mmol) was added to the mixture in oneportion, and mixing and cooling was maintained for an additional 15 -60 min, followed by ~30 min - 2.5 h at r.t. The reaction mixture wasthen diluted with ether (10 mL) and the organic phase separated. Thewater phase was further washed with ether (10 mL). The combinedorganic phase was dried over anhydrous Na2SO4 and the solvent evaporatedto provide a crude product which was purified using columnchromatography on silica gel
  • 70
  • [ 1191-62-4 ]
  • C79H126F2N24O27S [ No CAS ]
  • C87H142N24O27S3 [ No CAS ]
  • 71
  • [ 1191-62-4 ]
  • C79H126F2N24O27S [ No CAS ]
  • C87H142N24O27S3 [ No CAS ]
  • 72
  • [ 1191-62-4 ]
  • C79H126F2N24O27S [ No CAS ]
  • C87H142N24O27S3 [ No CAS ]
  • 73
  • [ 1191-62-4 ]
  • C79H126F2N24O27S [ No CAS ]
  • C87H142N24O27S3 [ No CAS ]
  • 74
  • [ 1191-62-4 ]
  • C86H131F2N27O25 [ No CAS ]
  • C94H147N27O25S2 [ No CAS ]
  • 75
  • [ 1191-62-4 ]
  • C86H131F2N27O25 [ No CAS ]
  • C94H147N27O25S2 [ No CAS ]
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Historical Records