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[ CAS No. 1191911-27-9 ] {[proInfo.proName]}

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Chemical Structure| 1191911-27-9
Chemical Structure| 1191911-27-9
Structure of 1191911-27-9 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1191911-27-9 ]

CAS No. :1191911-27-9 MDL No. :MFCD26401527
Formula : C22H25ClN6O4S Boiling Point : -
Linear Structure Formula :- InChI Key :CLGWUCNXOBLWFM-UHFFFAOYSA-N
M.W : 504.99 Pubchem ID :44252734
Synonyms :
Chemical Name :N-(2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide

Safety of [ 1191911-27-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1191911-27-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1191911-27-9 ]

[ 1191911-27-9 ] Synthesis Path-Downstream   1~1

  • 1
  • N4-(2-aminophenyl)-5-chloro-N2-(2-methoxy-4-morpholinophenyl)pyrimidin-2,4-diamine [ No CAS ]
  • [ 124-63-0 ]
  • [ 1191911-27-9 ]
YieldReaction ConditionsOperation in experiment
32% With triethylamine In dichloromethane at 0 - 20℃; 32.3 Step 3: Step 3: Preparation of N-(2-((5-chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)me thanesulfonamide To dichloromethane (2 mL) of N4-(2-aminophenyl)-5-chloro-N2-(2-methoxy-4-morpholinophenyl)pyrimidin-2,4-diamine (43.2 mg, 0.10 mmol) were added triethylamine (50 μL, 0.40 mmol) and methanesulfonyl chloride (30 μL, 0.30 mmol) at 0 °C. The above reaction mixture was stirred overnight at ambient temperature. The above mixture was concentrated under reduced pressure, and the residue was purified by flash column chromatography (CH2Cl2/EtOAc, 5:1) to obtain N-(2-((5-chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)me thanesulfonamide (16.1 mg, pale yellow solid) in a yield of 32%. 1H NMR (300 MHz, CDCl3) δ 8.07 (s, 1 H), 7.77 (d, J = 8.8 Hz, 1 H), 7.70-7.67 (m, 1 H), 7.53-7.50 (m, 1 H), 7.45 (br s, 1 H), 7.34-7.30 (m, 2 H), 7.27 (br s, 1 H), 6.47 (sd, J = 2.5 Hz, 1 H), 6.30 (dd, J = 8.9, 2.5 Hz, 1 H), 3.88-3.85 (m, 4 H), 3.83 (s, 3 H), 3.10-3.07 (m, 4 H), 2.90 (s, 3 H); LC-MS calcd for C22H26ClN6O4S 505.1, found 504.9 (M + H+)
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[ 1191911-27-9 ]

Chemical Structure| 1784253-05-9

A1500046[ 1784253-05-9 ]

N-(2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide hydrochloride

Reason: Free-Salt