Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 1191911-27-9 | MDL No. : | MFCD26401527 |
Formula : | C22H25ClN6O4S | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | CLGWUCNXOBLWFM-UHFFFAOYSA-N |
M.W : | 504.99 | Pubchem ID : | 44252734 |
Synonyms : |
|
Chemical Name : | N-(2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
32% | With triethylamine In dichloromethane at 0 - 20℃; | 32.3 Step 3: Step 3: Preparation of N-(2-((5-chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)me thanesulfonamide To dichloromethane (2 mL) of N4-(2-aminophenyl)-5-chloro-N2-(2-methoxy-4-morpholinophenyl)pyrimidin-2,4-diamine (43.2 mg, 0.10 mmol) were added triethylamine (50 μL, 0.40 mmol) and methanesulfonyl chloride (30 μL, 0.30 mmol) at 0 °C. The above reaction mixture was stirred overnight at ambient temperature. The above mixture was concentrated under reduced pressure, and the residue was purified by flash column chromatography (CH2Cl2/EtOAc, 5:1) to obtain N-(2-((5-chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)me thanesulfonamide (16.1 mg, pale yellow solid) in a yield of 32%. 1H NMR (300 MHz, CDCl3) δ 8.07 (s, 1 H), 7.77 (d, J = 8.8 Hz, 1 H), 7.70-7.67 (m, 1 H), 7.53-7.50 (m, 1 H), 7.45 (br s, 1 H), 7.34-7.30 (m, 2 H), 7.27 (br s, 1 H), 6.47 (sd, J = 2.5 Hz, 1 H), 6.30 (dd, J = 8.9, 2.5 Hz, 1 H), 3.88-3.85 (m, 4 H), 3.83 (s, 3 H), 3.10-3.07 (m, 4 H), 2.90 (s, 3 H); LC-MS calcd for C22H26ClN6O4S 505.1, found 504.9 (M + H+) |