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Chemical Structure| 1193447-34-5 Chemical Structure| 1193447-34-5

Structure of CRANAD-2
CAS No.: 1193447-34-5

Chemical Structure| 1193447-34-5

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CRANAD-2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-fold fluorescence intensity increase, a 90 nm blue shift (from 805 to 715 nm), and a large increase in quantum yield. Moreover, this probe also shows a high affinity for Abeta aggregates (K(d) = 38.0 nM), a reasonable log P value (log P = 3), considerable stability in serum, and a weak interaction with albumin. After intravenous injection of this probe, 19-month-old Tg2576 mice exhibited significantly higher relative signal than that of the control mice over the same period of time.

Synonyms: CRANAD-2

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Product Details of CRANAD-2

CAS No. :1193447-34-5
Formula : C23H25BF2N2O2
M.W : 410.26
SMILES Code : CN(C)C(C=C1)=CC=C1/C=C/C2=O[B+3]([F-])([F-])O=C(/C=C/C3=CC=C(C=C3)N(C)C)[CH-]2
Synonyms :
CRANAD-2
MDL No. :MFCD25563253

Safety of CRANAD-2

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P305+P351+P338

Isoform Comparison

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.44mL

0.49mL

0.24mL

12.19mL

2.44mL

1.22mL

24.37mL

4.87mL

2.44mL

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