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Chemical Structure| 120-97-8 Chemical Structure| 120-97-8

Structure of Dichlorphenamide
CAS No.: 120-97-8

Chemical Structure| 120-97-8

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Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor with Kis of 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively.

Synonyms: Diclofenamide

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Product Details of Dichlorphenamide

CAS No. :120-97-8
Formula : C6H6Cl2N2O4S2
M.W : 305.16
SMILES Code : O=S(C1=C(Cl)C(Cl)=CC(S(=O)(N)=O)=C1)(N)=O
Synonyms :
Diclofenamide
MDL No. :MFCD00148948
InChI Key :GJQPMPFPNINLKP-UHFFFAOYSA-N
Pubchem ID :3038

Safety of Dichlorphenamide

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317-H319-H351-H361
Precautionary Statements:P280-P305+P351+P338

Isoform Comparison

Biological Activity

Target
  • Carbonic Anhydrase

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00494507 Hyperkalemic Periodic Paralysi... More >>s Hypokalemic Periodic Paralysis Less << Phase 3 Completed - United States, California ... More >> UCLA Neurology Los Angeles, California, United States, 90095 University of California-San Francisco San Francisco, California, United States, 94143 United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States, 66160 United States, Massachusetts Brigham & Women's Hospital Boston, Massachusetts, United States, 02115 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 United States, New York Columbia University Medical Center New York, New York, United States, 10032 University of Rochester Rochester, New York, United States, 14642 United States, Ohio Ohio State University Columbus, Ohio, United States, 43210 United States, Texas University of Texas Southwestern-Dallas Dallas, Texas, United States, 75390 Italy University of Milan San Donato, Milan, Italy United Kingdom Institute of Neurology-Queen's Square London, United Kingdom Less <<
NCT00004802 Paralysis, Hyperkalemic Period... More >>ic Hypokalemic Periodic Paralysis Paramyotonia Congenita Less << Phase 3 Completed - -
NCT00494507 - Completed - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.28mL

0.66mL

0.33mL

16.38mL

3.28mL

1.64mL

32.77mL

6.55mL

3.28mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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