Alternatived Products of [ 120157-94-0 ]
Product Details of [ 120157-94-0 ]
CAS No. : | 120157-94-0 |
MDL No. : | MFCD21105772 |
Formula : |
C13H19NO3
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
237.30
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 120157-94-0 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 120157-94-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 120157-94-0 ]
- 1
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[ 41840-28-2 ]
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[ 2393-23-9 ]
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[ 120157-94-0 ]
Yield | Reaction Conditions | Operation in experiment |
92% |
With triethylamine In 1,4-dioxane; water for 6h; Ambient temperature; |
|
- 2
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[ 60421-23-0 ]
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[ 120157-94-0 ]
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[ 109-52-4 ]
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2-butyl-3-(4-methoxy-benzyl)-1,3-diaza-spiro[4.4]non-1-en-4-one
[ No CAS ]
- 3
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[ 24424-99-5 ]
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[ 2393-23-9 ]
-
[ 120157-94-0 ]
Yield | Reaction Conditions | Operation in experiment |
100% |
With triethylamine In dichloromethane at 0 - 20℃; |
|
98% |
In water at 80℃; for 0.0833333h; Microwave irradiation; Green chemistry; chemoselective reaction; |
|
95% |
With choline chloride; urea at 50℃; Green chemistry; |
General procedure
General procedure: A dried test tube, equipped with a magnetic stir bar, wascharged with 0.5 cm3 DES, amine derivatives(0.5 mmol), and Boc2O (0.5 mmol) and the mixture washeated at 50 C until the reaction was complete (monitoredby TLC and IR). After this time, 5 cm3 water wasadded and in the most cases a white solid was obtained.The solid product was collected by filtration and washedsuccessively with water and recrystallized from ethanolto get the pure final product [51-60]. The viscousproducts extracted with ethyl acetate and were purifiedby column chromatography, using ethyl acetate-petroleumether. |
93% |
With pyridinium trifluroacetate In neat (no solvent) at 20℃; for 0.05h; Green chemistry; |
General procedure for the N-Boc protection of amines
General procedure: To a magnetically stirred mixture of amine (1mmol) and (Boc)2O (1mmol) a catalytic amount of ionic liquid (0.2mmol) was added under solvent-free conditions at room temperature for the specified period of time. The progress of the reaction was monitored by TLC and GC-MS. The mixture extraction was carried out using ethyl acetate (2×5mL). The organic layer was washed with water (2×10mL) and dried over anhydrous Na2SO4. The solvent was evaporated under vacuum to yield highly pure N-Boc derivatives. In some cases, the purification was done by column chromatography using silica gel (60-120) by hexane-ethyl acetate as eluent to get a pure product. |
Reference:
[1]Location in patent: experimental part
Kapeller, Dagmar C.; Hammerschmidt, Friedrich
[Chemistry - A European Journal, 2009, vol. 15, # 23, p. 5729 - 5739]
[2]Nardi; Cano, N. Herrera; Costanzo; Oliverio; Sindona; Procopio
[RSC Advances, 2015, vol. 5, # 24, p. 18751 - 18760]
[3]Azizi, Najmedin; Shirdel, Fatemeh
[Monatshefte fur Chemie, 2017, vol. 148, # 6, p. 1069 - 1074]
[4]Karimian, Somaye; Tajik, Hassan
[Chinese Chemical Letters, 2014, vol. 25, # 2, p. 218 - 220]
- 4
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[ 623-12-1 ]
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[ 1314538-55-0 ]
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[ 120157-94-0 ]
- 5
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[ 1314538-55-0 ]
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[ 19013-30-0 ]
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[ 120157-94-0 ]
- 6
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[ 1314538-55-0 ]
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[ 1138-62-1 ]
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[ 120157-94-0 ]
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